The major goal of this Program Project Grant (PPG) is to gain insight into the regulation of hypoxic adenosine responses in acute and chronic settings in order to advance novel adenosine-based therapies for the treatment of lung disease. The Project Leaders of this PPG have made substantial contributions to the understanding of adenosine signaling and the regulation of different injury processes, including acute and chronic lung disease. Furthermore, pharmaceutical companies are actively developing adenosine-based therapies to treat various disorders including lung disease. However, confusion over the beneficial and detrimental aspects of adenosine signaling has hindered these efforts. The experiments planned in the Component Projects of this PPG will address aspects of adenosine signaling in acute and chronic disease states with a focus on lung disease, and they will interact scientifically to understand organ and stage- specific aspects of adenosine signaling. It is hoped that the knowledge gained will help guide the development of specific adenosine-based therapies. However, we feel that this goal will be facilitated further by establishing mechanisms that promote interactions amongst the Project Research Teams, The Cores and Advisory Board Members. Thus, a major goal of this Administrative Core will be to provide administrative assistance to facilitate scheduled monthly meetings, Bi-Annual Project Leader Conferences, and a yearly PPG Scientific Retreat. These activities will focus on the exchange of data and ideas to understand the differences and similarities of the hypoxic adenosine response in different environments, and promote the importance of this pathway to the greater scientific community. Other goals of this Core include providing the administrative structure to assure the successful use of the Scientific Cores and the exchange of data and research material, monitor scientific progress of the Projects, address concerns, monitor compliance issues, and facilitate the presentation and publication of scientific results. By achieving these goals, this Administrative Core will contribute to the overall success and significance of this PPG.

Public Health Relevance

Acute and chronic lung diseases are the third leading cause of death behind cancer and cardiovascular disease. This is due in part to an incomplete understanding of injury responses in the lung. This Administrative Core is highly relevant to the betterment of human disease in that it will seek to facilitate interactions that are geared towards understanding novel mechanisms of lung disease that may lead to new treatments for these deadly lung disorders.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL114457-02
Application #
8665476
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$74,412
Indirect Cost
$25,457
Name
University of Texas Health Science Center Houston
Department
Type
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225
Kork, Felix; Eltzschig, Holger K (2017) The Devil Is in the Detail: Remote Ischemic Preconditioning for Perioperative Kidney Protection. Anesthesiology 126:763-765
Song, Anren; Zhang, Yujin; Han, Leng et al. (2017) Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun 8:14108
Huang, Aji; Wu, Hongyu; Iriyama, Takayuki et al. (2017) Elevated Adenosine Induces Placental DNA Hypomethylation Independent of A2B Receptor Signaling in Preeclampsia. Hypertension 70:209-218
Hoegl, Sandra; Ehrentraut, Heidi; Brodsky, Kelley S et al. (2017) NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury. J Leukoc Biol 101:471-480
Philip, Kemly; Mills, Tingting Weng; Davies, Jonathan et al. (2017) HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis. FASEB J 31:4745-4758
He, Baokun; Hoang, Thomas K; Wang, Ting et al. (2017) Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors. J Exp Med 214:107-123
Neudecker, Viola; Haneklaus, Moritz; Jensen, Owen et al. (2017) Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. J Exp Med 214:1737-1752
Varadarajan, Supraja G; Kong, Jennifer H; Phan, Keith D et al. (2017) Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord. Neuron 94:790-799.e3
Wirsdörfer, Florian; de Leve, Simone; Cappuccini, Federica et al. (2016) Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis. Cancer Res 76:3045-56
Luo, Renna; Liu, Chen; Elliott, Serra E et al. (2016) Transglutaminase is a Critical Link Between Inflammation and Hypertension. J Am Heart Assoc 5:

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