The Core B (Animal Model Core) for the MCW P01 program project grant, entitled ?Renal Mechanisms in Blood Pressure Control?, will support program project investigators with comprehensive management of several novel genetically engineered rat models. The need for Core B is apparent considering current heavy use of rat models and the numbers of animals proposed. Throughout the history of the PPG, Core B has provided a centralized approach to managing rat models to achieve the proposed studies. The overall goal of Core B is to assist program project investigators with the development, management, genotyping, distribution, and molecular characterization of the models. Multiple approaches will be available to develop new models as needed by the Project investigators. Core B will serve as an invaluable resource for the project investigators to define the novel mechanisms that lead to the control of blood pressure and kidney diseases. Core staff will also assist in experimental design and training of the laboratory staff, and participate in data collection, analysis, and preparation for publication.
Animal Model Core B is an essential component of this grant and will support all three projects of this PPG. The three scientific projects share the common goal of providing novel insights into the mechanisms and functional pathways underlying the development of salt-sensitive hypertension and renal damage. The overall goal of Core B is to manage, genotype distribute, and assist in the molecular characterization of several genetically modified rat strains necessary to conduct the proposed studies.
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|Zheleznova, Nadezhda N; Yang, Chun; Cowley Jr, Allen W (2016) Role of Nox4 and p67phox subunit of Nox2 in ROS production in response to increased tubular flow in the mTAL of Dahl salt-sensitive rats. Am J Physiol Renal Physiol 311:F450-8|
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