The Administrative Core (Core D) is the integrating mechanism for all of the administrative, research and educational activities of the proposed (P01) Program Project Grant (PPG) entitled, ?Systems Biology of Airway Disease ? Program Project?. The Administrative Core has the following primary functions: To provide administrative and logistical support for all three scientific Projects and the three other Cores of the Program Project. Specifically, Core D will: 1. Provide administrative and coordinating support to Cores A, B and C and Projects 1, 2 and 3. 2. Integrate all research and educational activities for members of the PPG, and coordinate meetings with internal and external advisors of this study. 3. Coordinate all administrative interactions between the institutions involved in the PPG: Brigham and Women's Hospital (BWH), the Children's Mercy Hospitals and Clinics (CMH), the Harvard School of Public Health (HSPH), National Jewish Health (NJH), Northeastern University (NEU), Washington University (WUSTL) and the NHLBI. 4. Serve as the central administrator of common funds to support all BWH-based Projects and Cores, including funds for scientific and administrative travel of investigators, publications, project supplies, honoraria and associated costs for Advisory Committee members, and all other allowable miscellaneous project expenses. This Core will be directed by Dr. Scott T. Weiss, a senior research scientist, with over 40 years of research and administrative experience. Core members include the PIs of all Projects and Cores of the proposed PPG (i.e., Dr. Weiss (Project 1), Dr. Benjamin A. Raby (Project 2), Dr. Dawn L. DeMeo (Project 3), Dr. Albert-Lszl Barabsi (Core A), Dr. Christoph Lange (Core B), Dr. Anny Xiaobo Zhou (Core C); Dr. Edwin Silverman will also be part of the Administrative Core as Co-Director of the PPG, Chief of the Channing Division of Network Medicine (CDNM), and co-investigator on Project 1 and Core D.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Special Emphasis Panel (HLBP (JH))
Program Officer
Gan, Weiniu
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Brigham and Women's Hospital
United States
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Dehmamy, Nima; Milanlouei, Soodabeh; Barabási, Albert-László (2018) A structural transition in physical networks. Nature 563:676-680
Santolini, Marc; Barabási, Albert-László (2018) Predicting perturbation patterns from the topology of biological networks. Proc Natl Acad Sci U S A 115:E6375-E6383
Zhou, Xuezhong; Lei, Lei; Liu, Jun et al. (2018) A Systems Approach to Refine Disease Taxonomy by Integrating Phenotypic and Molecular Networks. EBioMedicine 31:79-91
Hecker, Julian; Xu, Xin; Townes, F William et al. (2018) Family-based tests for associating haplotypes with general phenotype data: Improving the FBAT-haplotype algorithm. Genet Epidemiol 42:123-126
Yun, Jeong H; Lamb, Andrew; Chase, Robert et al. (2018) Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol 141:2037-2047.e10
Peng, Cheng; Cardenas, Andres; Rifas-Shiman, Sheryl L et al. (2018) Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach. Clin Epigenetics 10:55
Morrow, Jarrett D; Cho, Michael H; Platig, John et al. (2018) Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease. Hum Genomics 12:1
Li, Xuan; Fu, Yuejiao; Wang, Xiaogang et al. (2018) Detecting Differentially Variable MicroRNAs via Model-Based Clustering. Int J Genomics 2018:6591634
Hecker, Julian; Prokopenko, Dmitry; Lange, Christoph et al. (2018) PolyGEE: a generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies. Biostatistics 19:295-306
Lopes-Ramos, Camila M; Kuijjer, Marieke L; Ogino, Shuji et al. (2018) Gene Regulatory Network Analysis Identifies Sex-Linked Differences in Colon Cancer Drug Metabolism. Cancer Res 78:5538-5547

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