The Retrovirus SIV/macaque Database was developed by Drs Mankowski and Tarwater to facilitate acquisition of the large quantity of data generated by the projects in the original CNS &Peripheral Reservoirs in SIV Model of HIV HAART Program Project Grant. It now includes over 300 SIV-infected and uninfected macaques, including over 250 pigtailed macaques inoculated under our dual infection protocol (accelerated, consistent model of SIV) and thus serves as the central repository for all virologic, immunologic, and pathologic measurements from all animals on study in the Retrovirus Lab over the last ten years. All data from the studies in this proposal will be added to the existing database, thereby integrating the data sets from past and prospective studies including all HAART-treated animals.
Aim 1 of this core encompasses the data management of all program projects to insure the accurate acquisition and efficient entry of all project data into our master database to facilitate investigator access.
Aim 2 of this core is to facilitate data analysis to provide advanced statistical analysis support for all investigators and research staff for each project and the entire integrated program using data compiled in the SIV/macaque master database.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program Projects (P01)
Project #
5P01MH070306-09
Application #
8453382
Study Section
Special Emphasis Panel (ZMH1-ERB-F)
Project Start
Project End
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
9
Fiscal Year
2013
Total Cost
$137,807
Indirect Cost
$72,776
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Meulendyke, Kelly A; Croteau, Joshua D; Zink, M Christine (2014) HIV life cycle, innate immunity and autophagy in the central nervous system. Curr Opin HIV AIDS 9:565-71
Meulendyke, Kelly A; Ubaida-Mohien, Ceereena; Drewes, Julia L et al. (2014) Elevated brain monoamine oxidase activity in SIV- and HIV-associated neurological disease. J Infect Dis 210:904-12
Abreu, Celina M; Price, Sarah L; Shirk, Erin N et al. (2014) Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR. PLoS One 9:e97257
Mangus, Lisa M; Dorsey, Jamie L; Laast, Victoria A et al. (2014) Unraveling the pathogenesis of HIV peripheral neuropathy: insights from a simian immunodeficiency virus macaque model. ILAR J 54:296-303
Meulendyke, Kelly A; Queen, Suzanne E; Engle, Elizabeth L et al. (2014) Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease. J Neurovirol 20:591-602
Akay, Cagla; Cooper, Michael; Odeleye, Akinleye et al. (2014) Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system. J Neurovirol 20:39-53
Dorsey, Jamie L; Mangus, Lisa M; Oakley, Jonathan D et al. (2014) Loss of corneal sensory nerve fibers in SIV-infected macaques: an alternate approach to investigate HIV-induced PNS damage. Am J Pathol 184:1652-9
Witwer, Kenneth W; McAlexander, Melissa A; Queen, Suzanne E et al. (2013) Real-time quantitative PCR and droplet digital PCR for plant miRNAs in mammalian blood provide little evidence for general uptake of dietary miRNAs: limited evidence for general uptake of dietary plant xenomiRs. RNA Biol 10:1080-6
Russell, Julia N; Clements, Janice E; Gama, Lucio (2013) Quantitation of gene expression in formaldehyde-fixed and fluorescence-activated sorted cells. PLoS One 8:e73849
Metcalf Pate, Kelly A; Lyons, Claire E; Dorsey, Jamie L et al. (2013) Platelet activation and platelet-monocyte aggregate formation contribute to decreased platelet count during acute simian immunodeficiency virus infection in pig-tailed macaques. J Infect Dis 208:874-83

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