Abstract

Thorough analyses of molecular mechanisms in cellular and developmental neuroscience requires an array of imaging tools and expertise. The purpose of this program project core is to provide the instrumentation and technical support to enable research staff in the three program laboratories to perform a wide range of imaging applications and image processing to extract quantitative mophometric data. The applications range from three types of confocal microscopy to wide-field fluorescence time-lapse microscopy to standard format imaging of fixed tissues.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
7P01NS040043-07
Application #
7312800
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
7
Fiscal Year
2006
Total Cost
$140,644
Indirect Cost

  Institution

Name
Harvard University
Department
Type
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Liu, Judy S; Schubert, Christian R; Fu, Xiaoqin et al. (2012) Molecular basis for specific regulation of neuronal kinesin-3 motors by doublecortin family proteins. Mol Cell 47:707-21
Loya, Carlos M; Van Vactor, David; Fulga, Tudor A (2010) Understanding neuronal connectivity through the post-transcriptional toolkit. Genes Dev 24:625-35
Tcherkezian, Joseph; Brittis, Perry A; Thomas, Franziska et al. (2010) Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell 141:632-44
Kim, Seonhee; Lehtinen, Maria K; Sessa, Alessandro et al. (2010) The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron 66:69-84
Loya, Carlos M; Lu, Cecilia S; Van Vactor, David et al. (2009) Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms. Nat Methods 6:897-903
Neal, Jason; Takahashi, Masaya; Silva, Matthew et al. (2007) Insights into the gyrification of developing ferret brain by magnetic resonance imaging. J Anat 210:66-77
Lu, Jie; Lian, Gewei; Lenkinski, Robert et al. (2007) Filamin B mutations cause chondrocyte defects in skeletal development. Hum Mol Genet 16:1661-75
Sheen, Volney L; Ferland, Russell J; Harney, Megan et al. (2006) Impaired proliferation and migration in human Miller-Dieker neural precursors. Ann Neurol 60:137-44
Olson, Eric C; Kim, Seonhee; Walsh, Christopher A (2006) Impaired neuronal positioning and dendritogenesis in the neocortex after cell-autonomous Dab1 suppression. J Neurosci 26:1767-75
Sheen, Volney L; Ferland, Russell J; Neal, Jason et al. (2006) Neocortical neuronal arrangement in Miller Dieker syndrome. Acta Neuropathol 111:489-96

Showing the most recent 10 out of 35 publications