An advantage of conducting research within a coordinated Program Project is the ability to create core facilities to (i) efficiently and economically share resources and administration support, (ii) provide infrastructure for the scientific objectives of the program, (iii) provide mechanisms for disseminating results and facilitating discussions within the group, and (iv) coordinate interactions with outside investigators to obtain critical evaluation, technical advice and intellectual input to keep the work on track and at the cutting edge of technologies in the field. To this end an Analytical, Administrative and Animal/Reagent Core (Core A) will be created and directed by Dr. Christine Gall. Core A will address 4 specific aims.
Aim 1 will be to maintain an Analytical Core for Microscopy, Electrophysiology, Behavior and Assay functions. Studies within Projects 1-4 entail analyses of long term potentiation (LTP) in hippocampal slices, localized signaling to actin, modulating endogenous BDNF protein content, and evaluation of treatment effects on unsupervised learning. This will be accomplished using Analytical Core facilities and personnel for microscopy-image analysis, electrophysiology, behavioral analysis (unsupervised learning) and protein assays.
Aim 2 will be to support Animal and Reagent functions. Core personnel will coordinate purchases of reagents and ampakines, support mouse colonies employed for UCl Projects, and perform genotyping.
Aim 3 will be to manage collaborations and integration of research among Project laboratories, and provide input from internal and external advisory boards (Administration). This includes coordinating both research activities among the projects for access to key analytical facilities (e.g., microscopic, electrophysiological and behavioral facilities and staff) and Program Project collaborative meetings. The Core will also convene meetings with Internal and External Advisory Boards, and seminar speakers.
Aim 4 is to provide general administrative support and computer assistance for all program investigators (Administration). This includes general administrative support for grants management, coordinating seminars, oversight of animal use in Core A, supervision of Core personnel, and maintenance of computer servers for Program activities. Overall the Core facilities and functions will provide critical integration of research within the Projects and will support technical platforms that are critical for reaching project goals.

Public Health Relevance

The program project will test if there are common neurobiological processes underlying cognitive impairments in different animal models and if up-regulating BDNF is a broadly effective therapeutic strategy. To meet these program goals is critical that the different subprojects use the same treatments and measures. The Core will assure this uniformity and will provide mechanisms for sharing critical analytical facilities, technical expertise, and research advances throughout the program.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
Project #
Application #
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Irvine
United States
Zip Code
Wang, Yubin; Hall, Randy A; Lee, Moses et al. (2017) The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation. Sci Rep 7:11771
Zhu, Guoqi; Briz, Victor; Seinfeld, Jeff et al. (2017) Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction. Sci Rep 7:42788
Wang, W; Cox, B M; Jia, Y et al. (2017) Treating a novel plasticity defect rescues episodic memory in Fragile X model mice. Mol Psychiatry :
Cox, Conor D; Palmer, Linda C; Pham, Danielle T et al. (2017) Experiential learning in rodents: past experience enables rapid learning and localized encoding in hippocampus. Learn Mem 24:569-579
Seinfeld, Jeff; Baudry, Neema; Xu, Xiaobo et al. (2016) Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice. eNeuro 3:
Chen, Yuncai; Molet, Jenny; Lauterborn, Julie C et al. (2016) Converging, Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses. J Neurosci 36:11295-11307
Wang, Yubin; Hersheson, Joshua; Lopez, Dulce et al. (2016) Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Cell Rep 16:79-91
Wang, Yubin; Lopez, Dulce; Davey, Pinakin Gunvant et al. (2016) Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury. Neurobiol Dis 93:121-8
Sun, Jiandong; Liu, Yan; Tran, Jennifer et al. (2016) mTORC1-S6K1 inhibition or mTORC2 activation improves hippocampal synaptic plasticity and learning in Angelman syndrome mice. Cell Mol Life Sci 73:4303-4314
Liu, Yan; Wang, Yubin; Zhu, Guoqi et al. (2016) A calpain-2 selective inhibitor enhances learning & memory by prolonging ERK activation. Neuropharmacology 105:471-477

Showing the most recent 10 out of 98 publications