CORE E - Surgery Core - Veronica Tom, Ph.D., PI The Research Projects outiined in this Program Project will elucidate our understanding of several therapeutic approaches to spinal cord injury. All of the Projects rely heavily upon animal models of spinal cord injury. Thus, for the success of each Project and for the Program Project as a whole, reliability of surgical procedures is key. The Surgery Core will focus on measures that would increase the consistency of the surgical procedures. Such consistency is integral to the success of the experiments outiined in each of the Research Projects and will improve confidence in the results obtained. We will train personnel for uniformity and identify individuals dedicated to performing specific procedures. To facilitate and standardize training, we have developed a manual describing our Surgery procedures and a videotape is now available for those learning a technique. We will also provide any necessary surgical supplies. Dr. Veronica Tom will direct the Surgery Core and Dr. Takayami Yamagami will supervise its daily operation. Since animal models of spinal cord injury are involved in all of the Research Projects, the Surgery Core will be utilized by each of the individual Projects.

Public Health Relevance

All of the individual Projects rely heavily upon animal models of spinal cord injury. Uniformity of all surgical procedures is critical to instill confidence in the results generated from the experiments outiined in the Projects. The Surgery Core will train personnel who will perform the various surgical procedures so that a high level of consistency will be established.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS055976-07
Application #
8652516
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
7
Fiscal Year
2014
Total Cost
$46,057
Indirect Cost
$16,247
Name
Drexel University
Department
Type
DUNS #
002604817
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Lee, Seung Joon; Kalinski, Ashley L; Twiss, Jeffery L (2014) Awakening the stalled axon - surprises in CSPG gradients. Exp Neurol 254:12-7
Jin, Ying; Bouyer, Julien; Haas, Christopher et al. (2014) Behavioral and anatomical consequences of repetitive mild thoracic spinal cord contusion injury in the rat. Exp Neurol 257:57-69
Singh, Anita; Krisa, Laura; Frederick, Kelly L et al. (2014) Forelimb locomotor rating scale for behavioral assessment of recovery after unilateral cervical spinal cord injury in rats. J Neurosci Methods 226:124-31
Graziano, Alessandro; Foffani, Guglielmo; Knudsen, Eric B et al. (2013) Passive exercise of the hind limbs after complete thoracic transection of the spinal cord promotes cortical reorganization. PLoS One 8:e54350
Houle, John D; Cote, Marie-Pascale (2013) Axon regeneration and exercise-dependent plasticity after spinal cord injury. Ann N Y Acad Sci 1279:154-63
Haas, Christopher; Fischer, Itzhak (2013) Human astrocytes derived from glial restricted progenitors support regeneration of the injured spinal cord. J Neurotrauma 30:1035-52
Liu, Gang; Detloff, Megan Ryan; Miller, Kassi N et al. (2012) Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury. Exp Neurol 233:447-56
Keeler, Benjamin E; Liu, Gang; Siegfried, Rachel N et al. (2012) Acute and prolonged hindlimb exercise elicits different gene expression in motoneurons than sensory neurons after spinal cord injury. Brain Res 1438:8-21
Ketschek, A R; Haas, C; Gallo, G et al. (2012) The roles of neuronal and glial precursors in overcoming chondroitin sulfate proteoglycan inhibition. Exp Neurol 235:627-37

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