CORE E - Surgery Core - Veronica Tom, Ph.D., PI The Research Projects outiined in this Program Project will elucidate our understanding of several therapeutic approaches to spinal cord injury. All of the Projects rely heavily upon animal models of spinal cord injury. Thus, for the success of each Project and for the Program Project as a whole, reliability of surgical procedures is key. The Surgery Core will focus on measures that would increase the consistency of the surgical procedures. Such consistency is integral to the success of the experiments outiined in each of the Research Projects and will improve confidence in the results obtained. We will train personnel for uniformity and identify individuals dedicated to performing specific procedures. To facilitate and standardize training, we have developed a manual describing our Surgery procedures and a videotape is now available for those learning a technique. We will also provide any necessary surgical supplies. Dr. Veronica Tom will direct the Surgery Core and Dr. Takayami Yamagami will supervise its daily operation. Since animal models of spinal cord injury are involved in all of the Research Projects, the Surgery Core will be utilized by each of the individual Projects.

Public Health Relevance

All of the individual Projects rely heavily upon animal models of spinal cord injury. Uniformity of all surgical procedures is critical to instill confidence in the results generated from the experiments outiined in the Projects. The Surgery Core will train personnel who will perform the various surgical procedures so that a high level of consistency will be established.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS055976-07
Application #
8652516
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
7
Fiscal Year
2014
Total Cost
$46,057
Indirect Cost
$16,247
Name
Drexel University
Department
Type
DUNS #
002604817
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Twiss, Jeffery L; Fainzilber, Mike (2016) Neuroproteomics: How Many Angels can be Identified in an Extract from the Head of a Pin? Mol Cell Proteomics 15:341-3
Detloff, Megan Ryan; Quiros-Molina, Daniel; Javia, Amy S et al. (2016) Delayed Exercise Is Ineffective at Reversing Aberrant Nociceptive Afferent Plasticity or Neuropathic Pain After Spinal Cord Injury in Rats. Neurorehabil Neural Repair 30:685-700
Sachdeva, Rahul; Farrell, Kaitlin; McMullen, Mary-Katharine et al. (2016) Dynamic Changes in Local Protein Synthetic Machinery in Regenerating Central Nervous System Axons after Spinal Cord Injury. Neural Plast 2016:4087254
Jin, Y; Bouyer, J; Shumsky, J S et al. (2016) Transplantation of neural progenitor cells in chronic spinal cord injury. Neuroscience 320:69-82
Sachdeva, Rahul; Theisen, Catherine C; Ninan, Vinu et al. (2016) Exercise dependent increase in axon regeneration into peripheral nerve grafts by propriospinal but not sensory neurons after spinal cord injury is associated with modulation of regeneration-associated genes. Exp Neurol 276:72-82
Yuan, Xiao-bing; Jin, Ying; Haas, Christopher et al. (2016) Guiding migration of transplanted glial progenitor cells in the injured spinal cord. Sci Rep 6:22576
Twiss, Jeffery L; Kalinski, Ashley L; Sachdeva, Rahul et al. (2016) Intra-axonal protein synthesis - a new target for neural repair? Neural Regen Res 11:1365-1367
Hayakawa, Kazuo; Haas, Christopher; Fischer, Itzhak (2016) Examining the properties and therapeutic potential of glial restricted precursors in spinal cord injury. Neural Regen Res 11:529-33
Jin, Ying; Bouyer, Julien; Haas, Christopher et al. (2015) Evaluation of the anatomical and functional consequences of repetitive mild cervical contusion using a model of spinal concussion. Exp Neurol 271:175-88
Hayakawa, Kazuo; Haas, Christopher; Jin, Ying et al. (2015) Glial restricted precursors maintain their permissive properties after long-term expansion but not following exposure to pro-inflammatory factors. Brain Res 1629:113-25

Showing the most recent 10 out of 46 publications