CORE B: ADMINISTRATIVE CORE The overall goal of the Administrative Core is to provide administrative, fiscal and scientific management of this POl Program Project Grant. Key components of this Core will be to provide overall fiscal and administrative coordination. Additional objectives of this Core include organizing scientific interactions communications, and to coordinate interaction with NINDS.

Public Health Relevance

The multi-investigator components of a Program Project Grant require a central Adminisrative Core to assure standard adherence to NIH fiscal and research policies and to coordinate the communications among the groups.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS069539-03
Application #
8376801
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
3
Fiscal Year
2012
Total Cost
$80,128
Indirect Cost
$34,600
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Hendrickson, Peter G; Doráis, Jessie A; Grow, Edward J et al. (2017) Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons. Nat Genet 49:925-934
Campbell, Amy E; Oliva, Jonathan; Yates, Matthew P et al. (2017) BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells. Skelet Muscle 7:16
Jagannathan, Sujatha; Bradley, Robert K (2017) Congenital myotonic dystrophy-an RNA-mediated disease across a developmental continuum. Genes Dev 31:1067-1068
Feng, Qing; Jagannathan, Sujatha; Bradley, Robert K (2017) The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity. Mol Cell 67:239-251.e6
Lemmers, Richard Jlf; van der Vliet, Patrick J; Balog, Judit et al. (2017) Deep characterization of a common D4Z4 variant identifies biallelic DUX4 expression as a modifier for disease penetrance in FSHD2. Eur J Hum Genet :
Shadle, Sean C; Zhong, Jun Wen; Campbell, Amy E et al. (2017) DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. PLoS Genet 13:e1006658
Mason, Amanda G; Slieker, Roderick C; Balog, Judit et al. (2017) SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes. Skelet Muscle 7:12
van den Boogaard, Marlinde L; Lemmers, Richard J F L; Camaño, Pilar et al. (2016) Double SMCHD1 variants in FSHD2: the synergistic effect of two SMCHD1 variants on D4Z4 hypomethylation and disease penetrance in FSHD2. Eur J Hum Genet 24:78-85
Mul, Karlien; van den Boogaard, Marlinde L; van der Maarel, Silvère M et al. (2016) Integrating clinical and genetic observations in facioscapulohumeral muscular dystrophy. Curr Opin Neurol 29:606-13
Knopp, Paul; Krom, Yvonne D; Banerji, Christopher R S et al. (2016) DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesis. J Cell Sci 129:3816-3831

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