The Administrative Core (Core A) will provide coordination of scientific activities for the 3 projects and 3 cores. It will also facilitate daily operations and longer term planning for the individual and overall scientific program. Statistical consultation will also be available from the Core via Chengjie Xiong, a biostatistician. Core A has 2 aims.
Specific Aim 1. To facilitate communication, data sharing, and organize meefings between project leaders and our internal and external advisory boards. Dr. Xiong, as biostatistician, will provide statistical consultation for the projects and cores.
Specific Aim 2 : To assist in sharing PPG generated research with the general scientific and lay community as well as within and among PPG investigators.
Alzheimer's disease (AD) is the most common cause of dementia. There is no effective treatment that slows the progression of the disease. This core will provide an organizational structure for our efforts to better understand the relationship between cellular communication in the brain (synaptic activity) and the development of Alzheimer's disease.
|Liao, Fan; Zhang, Tony J; Mahan, Thomas E et al. (2015) Effects of growth hormone-releasing hormone on sleep and brain interstitial fluid amyloid-? in an APP transgenic mouse model. Brain Behav Immun 47:163-71|
|Lim, Miranda M; Gerstner, Jason R; Holtzman, David M (2014) The sleep-wake cycle and Alzheimer's disease: what do we know? Neurodegener Dis Manag 4:351-62|
|Shinohara, Mitsuru; Fujioka, Shinsuke; Murray, Melissa E et al. (2014) Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease. Brain 137:1533-49|
|Medway, Christopher W; Abdul-Hay, Samer; Mims, Tynickwa et al. (2014) ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease. Mol Neurodegener 9:11|
|Tai, Leon M; Mehra, Shipra; Shete, Varsha et al. (2014) Soluble apoE/A? complex: mechanism and therapeutic target for APOE4-induced AD risk. Mol Neurodegener 9:2|
|Liu, Chia-Chen; Tsai, Chih-Wei; Deak, Ferenc et al. (2014) Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease. Neuron 84:63-77|
|Zhao, Jing; Fu, Yuan; Liu, Chia-Chen et al. (2014) Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway. J Biol Chem 289:11282-92|
|Martínez-Morillo, Eduardo; Hansson, Oskar; Atagi, Yuka et al. (2014) Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls. Acta Neuropathol 127:633-43|
|Kanekiyo, Takahisa; Xu, Huaxi; Bu, Guojun (2014) ApoE and A? in Alzheimer's disease: accidental encounters or partners? Neuron 81:740-54|
|Ju, Yo-El S; Lucey, Brendan P; Holtzman, David M (2014) Sleep and Alzheimer disease pathology--a bidirectional relationship. Nat Rev Neurol 10:115-9|
Showing the most recent 10 out of 15 publications