The overall goal ofthe Administrative Core is to provide administrative support to the individual projects and cores by facilitating interactions, information sharing, statistical analysis and data integration between Projects I-III and Cores B-D. The Administrative Core will also be responsible for the scheduling of monthly meetings with all project investigators that include: 1) critiques of recent extramural publications relevant to the goals of all projects;2) presentations by project investigators, particularly when data sets are being readied for publication;3) updates on changes in the resources, essential infrastructure, and financial status of the PPG;and 4) training of graduate students and postdoctoral fellows in literature research, identifying research subjects, experimental design, trouble-shooting of experimental issues, presentation of experimental data, paper writing, submission and revisions, as well as grant writing. Graduate students and postdoctoral fellows from all PIs'labs will participate in these training events. The Administrative Core will also organize a regular schedule of invited seminar speakers that address topics of both general and specific interest to each ofthe Projects. This program will be coordinated with the Loma Linda University School of Medicine, which will help support costs associated with this visiting scientist program. The Administrative Core will also organize the external advisory committee composed of prominent extramural scientists (see Introduction) who will visit the Center for Brain Hemorrhage Research on an annual basis to review progress and project status and then issue written assessments and recommendations for continued success. The Administrative Core will contract two statisticians to participate in data processing and analysis. Finally, the Administrative Core will also coordinate the collection and compilation of all details necessary for timely filing of annual progress reports.

Public Health Relevance

The Administrative Core is instrumental in the administrative support and evaluation of the activities of this PPG, including facilitating interactions, information sharing, statistical analysis, and other administrative issues.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
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Application #
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Loma Linda University
Loma Linda
United States
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Zhan, Yan; Krafft, Paul R; Lekic, Tim et al. (2015) Imatinib preserves blood-brain barrier integrity following experimental subarachnoid hemorrhage in rats. J Neurosci Res 93:94-103
Zheng, Yun; Hu, Qin; Manaenko, Anatol et al. (2015) 17?-Estradiol attenuates hematoma expansion through estrogen receptor ?/silent information regulator 1/nuclear factor-kappa b pathway in hyperglycemic intracerebral hemorrhage mice. Stroke 46:485-91
Liu, Fei; Hu, Qin; Li, Bo et al. (2014) Recombinant milk fat globule-EGF factor-8 reduces oxidative stress via integrin ?3/nuclear factor erythroid 2-related factor 2/heme oxygenase pathway in subarachnoid hemorrhage rats. Stroke 45:3691-7
Chen, Sheng; Feng, Hua; Sherchan, Prativa et al. (2014) Controversies and evolving new mechanisms in subarachnoid hemorrhage. Prog Neurobiol 115:64-91
Fujii, Mutsumi; Sherchan, Prativa; Soejima, Yoshiteru et al. (2014) Cannabinoid receptor type 2 agonist attenuates apoptosis by activation of phosphorylated CREB-Bcl-2 pathway after subarachnoid hemorrhage in rats. Exp Neurol 261:396-403
Krafft, Paul R; McBride, Devin W; Lekic, Tim et al. (2014) Correlation between subacute sensorimotor deficits and brain edema in two mouse models of intracerebral hemorrhage. Behav Brain Res 264:151-60
Ma, Qingyi; Chen, Sheng; Hu, Qin et al. (2014) Reply: To PMID 24273204. Ann Neurol 75:972-3
Li, Qian; Khatibi, Nikan; Zhang, John H (2014) Vascular neural network: the importance of vein drainage in stroke. Transl Stroke Res 5:163-6
Altay, Orhan; Suzuki, Hidenori; Hasegawa, Yu et al. (2014) Isoflurane on brain inflammation. Neurobiol Dis 62:365-71
Fujii, Mutsumi; Sherchan, Prativa; Krafft, Paul R et al. (2014) Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats. J Neurol Sci 342:101-6

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