The long-term goal ofthe project is to identify common and distinct features of behavioral changes after three types of brain injury (subarachnoid hemorhage, intracerebral hemorhage, and traumatic brain injury) and the response to therapeutic interventions (osteopontin, anti-PDGF, Cav-AP) that protect the blood brain barrier and reduce brain swelling. The Behavioral Core will complement the scientific role ofthe project by implementing methods that can directly compare and contrast injury phenotype and treatment outcomes on a large number of subjects. The Behavioral Core has three basic goals for this project: ? Acquire data encompassing a broad range of behavioral domains (motor, learning, short-term memory, long-term memory, anxiety, depression, balance / coordination) over 4 time points (baseline, 24 hours postinjury, 72 hours post-injury, and 25-35 days post-injury). * Determine the effects of injury type (control vs. SAH vs. ICH vs. TBI), treatment (none vs. osteopontin vs. anti-PDGF vs. Cav-AP) and time (e.g., days 1 and 3, days 25-35) on the overall behavioral profile, as well as injury x treatment x time interactions. * Determine relationships between behavior and biomarkers from each model using data from the other Cores. Statistical modeling will allow us to determine which behavioral deficits tend to cluster together, suggesting common biological mechanisms. Data will be collected and analyzed in waves, which will allow for constant quality control and cost effecfiveness. For example, if it becomes clear that a particular test is ineffective in determining group difference, that test may be removed from the battery to save time and money.

Public Health Relevance

Behavior represents the final common pathway of neurological disorders. Identification of common and distinct features of brain injuries and treatments will help to determine the relationships between various behaviors and different brain areas, as well as the optimal treatment strategy and dosage.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
Project #
Application #
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Loma Linda University
Loma Linda
United States
Zip Code
Wang, Yuechun; Sherchan, Prativa; Huang, Lei et al. (2017) Naja sputatrix Venom Preconditioning Attenuates Neuroinflammation in a Rat Model of Surgical Brain Injury via PLA2/5-LOX/LTB4 Cascade Activation. Sci Rep 7:5466
Akyol, Gokce Yilmaz; Manaenko, Anatol; Akyol, Onat et al. (2017) IVIG activates Fc?RIIB-SHIP1-PIP3 Pathway to stabilize mast cells and suppress inflammation after ICH in mice. Sci Rep 7:15583
Kim, Cherine H; McBride, Devin W; Sherchan, Prativa et al. (2017) Crotalus helleri venom preconditioning reduces postoperative cerebral edema and improves neurological outcomes after surgical brain injury. Neurobiol Dis 107:66-72
Ma, Li; Manaenko, Anatol; Ou, Yi-Bo et al. (2017) Bosutinib Attenuates Inflammation via Inhibiting Salt-Inducible Kinases in Experimental Model of Intracerebral Hemorrhage on Mice. Stroke 48:3108-3116
Rolland, William B; Krafft, Paul R; Lekic, Tim et al. (2017) Fingolimod confers neuroprotection through activation of Rac1 after experimental germinal matrix hemorrhage in rat pups. J Neurochem 140:776-786
Yu, Lingyan; Lu, Zhengyang; Burchell, Sherrefa et al. (2017) Adropin preserves the blood-brain barrier through a Notch1/Hes1 pathway after intracerebral hemorrhage in mice. J Neurochem 143:750-760
McBride, Devin W; Zhang, John H (2017) Precision Stroke Animal Models: the Permanent MCAO Model Should Be the Primary Model, Not Transient MCAO. Transl Stroke Res :
Hu, Qin; Manaenko, Anatol; Bian, Hetao et al. (2017) Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats. Stroke 48:1655-1664
Zhang, John H; Obenaus, Andre; Liebeskind, David S et al. (2017) Recanalization, reperfusion, and recirculation in stroke. J Cereb Blood Flow Metab 37:3818-3823
Obenaus, Andre; Ng, Michelle; Orantes, Amanda M et al. (2017) Traumatic brain injury results in acute rarefication of the vascular network. Sci Rep 7:239

Showing the most recent 10 out of 52 publications