Objective: To facilitate imaging acquisition and support neurobehavioral studies and follow-up proposed in Projects 1-3 of the grant. We propose the following three Specific Aims:
Aim 1. To provide imaging support to include volumetric T l , T2, Diffusion Weighted Imaging, Functional Imaging, Perfusion Imaging, and Proton MR spectroscopy for the clinical projects. The Core team will provide logistical support for clinical imaging procedures as well as post-processing and data management. In this way, the Services Core not only provides the support for each project but provides the hub where all imaging data can be processed, shared and utilized to the benefit of each project.
Aim 2. To provide a neurobehavioral core for the three projects where all testing will be done. In addition, it will provide the support needed to track and maintain accurate follow up for all projects.
Aim 3. Continue to maintain and follow-up of the cohort created from prior funding. Over the twenty-year existence of our program, we have accumulated a large patient dataset.
We aim to keep in contact with these patients for the possibility of future imaging and/or neurological exams to investigate long-term outcome effects. The following described infrastructure will enable Service Core B to effectively communicate with individual projects and provide technical developments and services in cost-effective ways: 1) The Service Core B counterparts will vyork as an integral team and inform all projects on a regular basis. 2) Neurobehavioral testing, done both in the High Risk Follow-up Clinic and through the Program Project, will be coordinated here to allow for complete integration of all services and accurate follow-up. 3) Personnel in the Core (clinical nurses and research assistant) will support all three clinical projects, as needed. 4) The imaging and neurobehavioral data will be acquired and processed by Service Core B, then electronically transferred to Service Core A for data storage and management, further contributing to integration with the P01.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
1P01NS082330-01A1
Application #
8653662
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
2014-01-01
Project End
2018-12-31
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
1
Fiscal Year
2014
Total Cost
$359,464
Indirect Cost
$129,426
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Peyvandi, Shabnam; De Santiago, Veronica; Chakkarapani, Elavazhagan et al. (2016) Association of Prenatal Diagnosis of Critical Congenital Heart Disease With Postnatal Brain Development and the Risk of Brain Injury. JAMA Pediatr 170:e154450
Kim, Hosung; Lepage, Claude; Maheshwary, Romir et al. (2016) NEOCIVET: Towards accurate morphometry of neonatal gyrification and clinical applications in preterm newborns. Neuroimage 138:28-42
Gano, Dawn; Ho, Mai-Lan; Partridge, John Colin et al. (2016) Antenatal Exposure to Magnesium Sulfate Is Associated with Reduced Cerebellar Hemorrhage in Preterm Newborns. J Pediatr 178:68-74
Kim, Hosung; Gano, Dawn; Ho, Mai-Lan et al. (2016) Hindbrain regional growth in preterm newborns and its impairment in relation to brain injury. Hum Brain Mapp 37:678-88
Kim, Hosung; Joo, EunYeon; Suh, Sooyeon et al. (2016) Effects of long-term treatment on brain volume in patients with obstructive sleep apnea syndrome. Hum Brain Mapp 37:395-409
Tam, Emily W Y; Chau, Vann; Barkovich, A James et al. (2016) Early postnatal docosahexaenoic acid levels and improved preterm brain development. Pediatr Res 79:723-30
Kansagra, Akash P; Mabray, Marc C; Ferriero, Donna M et al. (2016) Microstructural maturation of white matter tracts in encephalopathic neonates. Clin Imaging 40:1009-13
Gano, Dawn; Andersen, Sarah K; Partridge, J Colin et al. (2015) Diminished white matter injury over time in a cohort of premature newborns. J Pediatr 166:39-43
Peyvandi, S; Feldstein, V A; Hirose, S et al. (2015) Twin-reversed arterial perfusion sequence associated with decreased fetal cerebral vascular impedance. Ultrasound Obstet Gynecol 45:447-51
Chen, Yiran; Tymofiyeva, Olga; Hess, Christopher P et al. (2015) Effects of rejecting diffusion directions on tensor-derived parameters. Neuroimage 109:160-70

Showing the most recent 10 out of 17 publications