The availability of biological samples from individuals with alcoholic liver disease (ALD), as well as samples from appropriate healthy controls, is an essential first step in the translation of basic research advances to the clinic. The purpose of the Clinical Core component of the P20 Exploratory Cleveland Alcohol Center is to provide biological samples (plasma and peripheral blood mononuclear cells (PBMCs)) from patients with severe alcoholic steatohepatitis, as well as healthy control subjects, to members of the Cleveland Alcohol Center. These samples can then be used to test specific hypotheses related to the presence of specific biomarkers in the serum, such as oxidized phospholipids, and PBMCs, such as responsivity to specific activating ligands, as well as genetic polymorphisms that may predict severity of disease, short- and long-term morbidity and mortality and/or responsivity to specific therapeutic interventions commonly used in clinical practice.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Exploratory Grants (P20)
Project #
5P20AA017837-04
Application #
8379781
Study Section
Special Emphasis Panel (ZAA1-BB)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
4
Fiscal Year
2012
Total Cost
$31,268
Indirect Cost
$13,592
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
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