) We propose to establish the """"""""Aging and Cancer Program"""""""" within the University of Wisconsin-Madison Comprehensive Cancer Center (UWCCC). We are uniquely positioned to do so as this application rests on the strong foundation provided by a large, growing and diverse aging research program that will interact productively with the investigators and resources of the UWCCC. Studies on sociological, psychological, health services and biomedical aspects of aging have long been pursued at the UW-Madison and are vigorously expanding as evidenced by an impressive portfolio of NIA grant support. These studies are incredibly diverse and include NIA support for three Program Projects: two large, long-term, longitudinal population-based studies (""""""""Wisconsin Longitudinal Study"""""""" and """"""""Integrative Pathways to Health and Illness- MIDUS""""""""), and """"""""Dietary Restriction in Rhesus Monkeys"""""""". Aging research is also supported by strong units including the UW's Institute on Aging, the Department of Medicine's Section of Geriatrics and Gerontology, and the VA GRECC. Additional important support is derived from other NIH-funded Centers including those for the Study of Mind-Body Interaction (NIMH) and Demography of Health and Aging (NIA) and the Wisconsin Interdisciplinary Molecular Imaging Center (NCI). The existing links between the UW aging community and the UWCCC, while not entirely absent, are largely biomedical. However, we have powerful scientific strengths in both aging and cancer such that we could not be better positioned to create and build synergies between these two areas. Further, past barriers to such collaboration no longer exist and significant institutional support for building this new program has been committed. Accordingly, under the leadership of Richard Weindruch, Ph.D., a gerontologist who has long investigated spontaneous late-life cancers in rodent models, we have formed a group of cancer biologists, gerontologists, oncologists, geriatricians and population scientists to address five thematic areas: Patterns of Care (Maureen Smith, MD, PhD, MPH [Leader], Gary Shapiro, MD [Co-Leader]); Effects of Comorbidity (Sanjay Asthana, MD, James Stewart, MD); Psychosocial Issues (Susan Heidrich, PhD, Carol Ryff, PhD); Palliative Care (James Cleary, MD, Elizabeth Kramer, PhD); and Biology of Aging and Cancer (Richard Weindruch, PhD, David Jarrard, MD). We view the creation of this Program and the research it will nurture to be vital in view of demographic realities and opportunities to address critical knowledge gaps.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory Grants (P20)
Project #
5P20CA103697-04
Application #
7117249
Study Section
Special Emphasis Panel (ZCA1-GRB-H (O1))
Program Officer
Shafik, Hasnaa
Project Start
2003-09-30
Project End
2008-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
4
Fiscal Year
2006
Total Cost
$604,890
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Donohue, SarahMaria; Haine, James E; Li, Zhanhai et al. (2017) Cancer Survivorship Care Plan Utilization and Impact on Clinical Decision-Making at Point-of-Care Visits with Primary Care: Results from an Engineering, Primary Care, and Oncology Collaborative for Survivorship Health. J Cancer Educ :
Wisinski, Kari B; Xu, Wei; Tevaarwerk, Amye J et al. (2016) Targeting Estrogen Receptor Beta in a Phase 2 Study of High-Dose Estradiol in Metastatic Triple-Negative Breast Cancer: A Wisconsin Oncology Network Study. Clin Breast Cancer 16:256-61
Kramer, Betty J; Cleary, James F; Mahoney, Jane E (2014) Enhancing palliative care for low-income elders with chronic disease: feasibility of a hospice consultation model. J Soc Work End Life Palliat Care 10:356-77
Thraen-Borowski, Keith M; Trentham-Dietz, Amy; Edwards, Dorothy Farrar et al. (2013) Dose-response relationships between physical activity, social participation, and health-related quality of life in colorectal cancer survivors. J Cancer Surviv 7:369-78
Johnson, Laura E; Becker, Jordan T; Dubovsky, Jason A et al. (2013) Prostate carcinoma in transgenic Lewis rats - a tumor model for evaluation of immunological treatments. Chin Clin Oncol 2:
Visco, Carlo; Hoeller, Sylvia; Malik, Jeffrey T et al. (2011) Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component. Am J Surg Pathol 35:177-89
Kumar, M; Lu, Z; Takwi, A A L et al. (2011) Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene 30:843-53
Anderson, Rozalyn M; Weindruch, Richard (2010) Metabolic reprogramming, caloric restriction and aging. Trends Endocrinol Metab 21:134-41
Anderson, Rozalyn; Prolla, Tomas (2009) PGC-1alpha in aging and anti-aging interventions. Biochim Biophys Acta 1790:1059-66
Heidrich, Susan M; Brown, Roger L; Egan, Judith J et al. (2009) An individualized representational intervention to improve symptom management (IRIS) in older breast cancer survivors: three pilot studies. Oncol Nurs Forum 36:E133-43

Showing the most recent 10 out of 16 publications