The RFA, to which this Planning Center proposal is a response, is designed to encourage the establishment of a critical mass of investigators from a variety of backgrounds, to educate and inform the research community about the problems associated with benign urologic disease, and to develop components of the preliminary data and infrastructure which will be needed for subsequent Research Center proposals. It is clear that the problem of BPH/LUTS cannot be studied without a broader understanding of the relationship of this syndrome with other associated co-morbidities. The existence of many interacting and interrelated centers at Vanderbilt (Figure 1) makes this an ideal site to establish a Center in this area and for this reason we believe that such a Center is a goal which can be productive and should be pursued. Therefore the Planning Center to be established in this P20 proposal has the following goals: Help to create an environment that supports important and innovative research. Raise awareness and interest in BPH/LUTS and its relationship to other significant co-morbidities. Enhance benign urologic research education for students, scientists, and clinicians. Foster interdisciplinary collaborations, especially in the emerging areas of research, to catalyze new ideas and scientific approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Exploratory Grants (P20)
Project #
5P20DK090874-02
Application #
8150405
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (O1))
Program Officer
Hoshizaki, Deborah K
Project Start
2010-09-30
Project End
2013-07-31
Budget Start
2011-08-01
Budget End
2013-07-31
Support Year
2
Fiscal Year
2011
Total Cost
$560,232
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Surgery
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Lin-Tsai, Opal; Clark, Peter E; Miller, Nicole L et al. (2014) Surgical intervention for symptomatic benign prostatic hyperplasia is correlated with expression of the AP-1 transcription factor network. Prostate 74:669-79
Murff, Harvey J; Roumie, Christianne L; Greevy, Robert A et al. (2014) Thiazolidinedione and Metformin Use and the Risk of Benign Prostate Hyperplasia in Veterans with Diabetes Mellitus. J Mens Health 11:157-162
Strand, Douglas W; DeGraff, David J; Jiang, Ming et al. (2013) Deficiency in metabolic regulators PPAR? and PTEN cooperates to drive keratinizing squamous metaplasia in novel models of human tissue regeneration. Am J Pathol 182:449-59
Strand, D W; Jiang, M; Murphy, T A et al. (2012) PPAR? isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation. Cell Death Dis 3:e361
Jiang, Ming; Strand, Douglas W; Franco, Omar E et al. (2011) PPAR?: a molecular link between systemic metabolic disease and benign prostate hyperplasia. Differentiation 82:220-36