Exposure to metals during development and early in life is a critical public health issue, and both water and food can be vectors of exposure, especially to inorganic arsenic. However, limited data are available on the dietary exposure to metals for U.S. infants or the subsequent expression of this exposure in established biomarkers. Recent data, including our own preliminary results, suggest that rice and rice products are significant contributors to inorganic arsenic exposure. Building on the Dartmouth Superfund Program's prospective pregnancy cohort, this pilot project will explore dietary sources of metal exposure in a cohort of infants through the first year of life. The goal is to identify the contribution of diet to both metal exposure and the ability to reduce metal toxicity via potential modifying factors such as folate, iron, and vitamin B. The project will focus particularly on exposure through breast milk and infant formulas, but will also collect data on the period when infants transition to solid foods, especially rice cereals. Information regarding the diet of the infant (including breastfeeding; amounts of formula, cereals, solids, and water being consumed; and vitamin supplementation) will be collected every 2-3 months during the first year of life via a phone questionnaire. Toenail clippings and a urine sample will be taken from the infant at ~4 months, and lactating women who are using a breast pump to store milk for their infants will be encouraged to provide a sample of their milk at the same time. We will also obtain toenail clippings from the infant and mother at ~12 months, together with information about maternal diet over the past year using a food frequency questionnaire. We will compare the infant dietary data with arsenic in the toenail and urine samples, and also use data on arsenic metabolites in the urine sample as a marker of infant ability to metabolize arsenic postpartum. If we are able to identify the sources of infant metal exposure, or factors that appear to mitigate the effects of this exposure, we can initiate intervention studies to identify specific dietary recommendations for prevention of adverse outcomes.

Public Health Relevance

Early life exposures to arsenic and other metals influence not only child development and health, but also health later in life. This project will determine how infant diets affect exposure to metals, as well as the potential for particular nutrients to ameliorate this exposure. A major goal is to work towards specific recommendations regarding particularly dangerous or helpful diet items.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Exploratory Grants (P20)
Project #
5P20ES018175-03
Application #
8375005
Study Section
Special Emphasis Panel (ZES1-LKB-G)
Project Start
Project End
2013-11-30
Budget Start
2011-12-01
Budget End
2012-11-30
Support Year
3
Fiscal Year
2012
Total Cost
$48,556
Indirect Cost
$13,289
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Punshon, Tracy; Li, Zhigang; Marsit, Carmen J et al. (2016) Placental Metal Concentrations in Relation to Maternal and Infant Toenails in a U.S. Cohort. Environ Sci Technol 50:1587-94
Chernikova, Diana A; Koestler, Devin C; Hoen, Anne Gatewood et al. (2016) Fetal exposures and perinatal influences on the stool microbiota of premature infants. J Matern Fetal Neonatal Med 29:99-105
Carignan, Courtney C; Punshon, Tracy; Karagas, Margaret R et al. (2016) Potential Exposure to Arsenic from Infant Rice Cereal. Ann Glob Health 82:221-4
Carignan, Courtney C; Karagas, Margaret R; Punshon, Tracy et al. (2016) Contribution of breast milk and formula to arsenic exposure during the first year of life in a US prospective cohort. J Expo Sci Environ Epidemiol 26:452-7
Carignan, Courtney C; Cottingham, Kathryn L; Jackson, Brian P et al. (2015) Estimated exposure to arsenic in breastfed and formula-fed infants in a United States cohort. Environ Health Perspect 123:500-6
Shi, Xun; Ayotte, Joseph D; Onda, Akikazu et al. (2015) Geospatial association between adverse birth outcomes and arsenic in groundwater in New Hampshire, USA. Environ Geochem Health 37:333-51
Hoen, Anne G; Li, Jing; Moulton, Lisa A et al. (2015) Associations between Gut Microbial Colonization in Early Life and Respiratory Outcomes in Cystic Fibrosis. J Pediatr 167:138-47.e1-3
Davis, Matthew A; Higgins, John; Li, Zhigang et al. (2015) Preliminary analysis of in utero low-level arsenic exposure and fetal growth using biometric measurements extracted from fetal ultrasound reports. Environ Health 14:12
Hermand, Victor; Julio, Emilie; Dorlhac de Borne, François et al. (2014) Inactivation of two newly identified tobacco heavy metal ATPases leads to reduced Zn and Cd accumulation in shoots and reduced pollen germination. Metallomics 6:1427-40
Davis, Matthew A; Li, Zhigang; Gilbert-Diamond, Diane et al. (2014) Infant toenails as a biomarker of in utero arsenic exposure. J Expo Sci Environ Epidemiol 24:467-73

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