Alaska IDeA Network for Biomedical Excellence (INBRE)3 proposes to strengthen and expand our network for biomedical research and training that was begun in our INBRE1 and 2 programs. Research is focused on the interface of the environment, health and disease in people and animals (as per """"""""One Health""""""""). INBRE3 will support university-based scholars, who teach one another and their students and a network that links the University of Alaska (UA) campuses (Fairbanks, UAF;Anchorage, UAA;Southeast, UAS) to the workforce and hospitals of Alaska's cities and villages. Alaska Native (AN) perspectives and Alaska's unique environment and human and animal populations will be integrated in our 5 specific aims to enhance statewide biomedical research and health.
Aim 1 is to enhance and expand the multidisciplinary research and teaching network. INBRE3 network will provide biomedical research and'teaching resources to faculty and trainees from UAF, UAA, UAS campuses and learning centers across Alaska, partner government laboratories, AN tribal and health organizations. Specific goals in support of Aim 1 are for INBRE3 to foster UA biomedical educational programs by including an undergraduate minor, B.S./M.S. degrees, and a graduate certificate in biomedical sciences.
Aim 2 will support faculty, postdoctoral researchers, and graduate students. One example is a competitive seed grant aimed at building our capacity for extramural funding and the development of the basic to translational research endeavors.
Aim 3 will provide undergraduate research opportunities to support the pipeline leading toward biomedical research and health careers.
Aim 4 will enhance science and technology knowledge to build Alaska's workforce by faculty working with communities to develop research and education partnerships and expanding biomedical informatics with development of a core.
Aim 5 will enhance biomedical research in the western IDeA states with inter-state seed grants, student research experiences, scientific meetings and workshops, and a regional resource exchange to maximize the effectiveness of individual INBRE programs through collaboration. Thus, INBRE3 will enhance biomedical research capacity and serve the state of Alaska.

Public Health Relevance

INBRE3 will focus on Alaska's unique environment, populations, and exposure to contaminants to address critical global biomedical research priorities by incorporating existing strengths at UA with a translational perspective to advance our goal of One Health in Alaska. Specific aims will enhance biomedical research and training and build collaborations and infrastructure, to focus on health in Alaska and beyond.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103395-14
Application #
8686182
Study Section
Special Emphasis Panel (ZGM1-TWD-7 (IN))
Program Officer
Caldwell, Sheila
Project Start
2001-09-24
Project End
2019-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
14
Fiscal Year
2014
Total Cost
$3,863,717
Indirect Cost
$1,263,424
Name
University of Alaska Fairbanks
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
615245164
City
Fairbanks
State
AK
Country
United States
Zip Code
99709
Hueffer, Karsten; Khatri, Shailesh; Rideout, Shane et al. (2017) Rabies virus modifies host behaviour through a snake-toxin like region of its glycoprotein that inhibits neurotransmitter receptors in the CNS. Sci Rep 7:12818
Bailey, Isaac R; Laughlin, Bernard; Moore, Lucille A et al. (2017) Optimization of Thermolytic Response to A1 Adenosine Receptor Agonists in Rats. J Pharmacol Exp Ther 362:424-430
Lescak, Emily A; Milligan-Myhre, Kathryn C (2017) Teleosts as Model Organisms To Understand Host-Microbe Interactions. J Bacteriol 199:
Bhowmick, Saurav; Drew, Kelly L (2017) Arctic ground squirrel resist peroxynitrite-mediated cell death in response to oxygen glucose deprivation. Free Radic Biol Med 113:203-211
Bhowmick, Saurav; Moore, Jeanette T; Kirschner, Daniel L et al. (2017) Acidotoxicity via ASIC1a Mediates Cell Death during Oxygen Glucose Deprivation and Abolishes Excitotoxicity. ACS Chem Neurosci 8:1204-1212
Fahsbender, Elizabeth; Burns, Jennifer M; Kim, Stacy et al. (2017) Diverse and highly recombinant anelloviruses associated with Weddell seals in Antarctica. Virus Evol 3:vex017
Morrell, Austin; Tallino, Savannah; Yu, Lei et al. (2017) The role of insufficient copper in lipid synthesis and fatty-liver disease. IUBMB Life 69:263-270
Rupp, Jonathan C; Locatelli, Manon; Grieser, Alexis et al. (2017) Host Cell Copper Transporters CTR1 and ATP7A are important for Influenza A virus replication. Virol J 14:11
Bhowmick, Saurav; Moore, Jeanette T; Kirschner, Daniel L et al. (2017) Arctic ground squirrel hippocampus tolerates oxygen glucose deprivation independent of hibernation season even when not hibernating and after ATP depletion, acidosis, and glutamate efflux. J Neurochem 142:160-170
Mitra, Swarup; Bastos, Cristiane P; Chesworth, Savanna et al. (2017) Strain and sex based characterization of behavioral expressions in non-induced compulsive-like mice. Physiol Behav 168:103-111

Showing the most recent 10 out of 93 publications