The Developmental Research Project Program will build on expertise developed in IDeA Network for Biomedical Excellence (INBRE) programs 1 and 2 to take advantage of Alaska, its unique environment, animal and human populations, and exposure to contaminants. The program will leverage our biomedical research focus on basic leading to translational research to improve overall health in the state focusing on """"""""One Health"""""""" (interactions of environment, animals, people). We will support new and existing INBRE faculty, expand the network of INBRE faculty, and move toward a translational research perspective. To do this, we will make seed grants available to all INBRE affiliates. Priority for funding will go to junior and newly-hired faculty who do not have independent funding. Priority will also go to faculty whose projects are translational and compliant with institutional animal or human subjects research guidelines and University of Alaska (UA)'s Responsible Conduct of Research. Faculty who have already received INBRE funding will only be considered for additional funding if they are addressing novel areas or collaborations. These seed grants will act as a bridge for faculty to obtain extramural funding. Grant proposals will be reviewed externally by an expert in the field, and faculty will have a chance to re-write their proposals to improve and resubmit them for internal review based on feedback. All INBRE faculty are strongly encouraged to have mentors. While mentors will serve a more traditional role for junior faculty, they will act as consultants or collaborators for senior faculty. Faculty will also be supported with research infrastructure. INBRES relies on outstanding resources by the institution, several of which INBRE supports via staffing, maintenance, and puchase of new equipment. Faculty will be supported in their professional development by promoting networking, scientific ethics and skills training, and opportunities for presentations at INBRES events. To expand our network and broaden the range of expertise in the program, we will recruit faculty from clinical domains at UA, which will foster new collaborations. While maintaining basic biomedical research capacity among faculty, we will expand the potential for them to take a translational approach with improved access to clinical resources.

Public Health Relevance

By supporting faculty through seed grants, research infrastructure, and professional development, we will increase their ability to compete for ROI grants and other extramural support. The network of faculty will be expanded to broaden our range of expertise, available resources, and clinical collaborations. Building a translaitional research capacity at UA is essential to understanding at-risk populations and improve health.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103395-14
Application #
8715974
Study Section
Special Emphasis Panel (ZGM1-TWD-7 (IN))
Project Start
2014-08-01
Project End
2019-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
14
Fiscal Year
2014
Total Cost
$1,178,296
Indirect Cost
Name
University of Alaska Fairbanks
Department
Type
DUNS #
615245164
City
Fairbanks
State
AK
Country
United States
Zip Code
99709
Hueffer, Karsten; Khatri, Shailesh; Rideout, Shane et al. (2017) Rabies virus modifies host behaviour through a snake-toxin like region of its glycoprotein that inhibits neurotransmitter receptors in the CNS. Sci Rep 7:12818
Bailey, Isaac R; Laughlin, Bernard; Moore, Lucille A et al. (2017) Optimization of Thermolytic Response to A1 Adenosine Receptor Agonists in Rats. J Pharmacol Exp Ther 362:424-430
Lescak, Emily A; Milligan-Myhre, Kathryn C (2017) Teleosts as Model Organisms To Understand Host-Microbe Interactions. J Bacteriol 199:
Bhowmick, Saurav; Drew, Kelly L (2017) Arctic ground squirrel resist peroxynitrite-mediated cell death in response to oxygen glucose deprivation. Free Radic Biol Med 113:203-211
Bhowmick, Saurav; Moore, Jeanette T; Kirschner, Daniel L et al. (2017) Acidotoxicity via ASIC1a Mediates Cell Death during Oxygen Glucose Deprivation and Abolishes Excitotoxicity. ACS Chem Neurosci 8:1204-1212
Fahsbender, Elizabeth; Burns, Jennifer M; Kim, Stacy et al. (2017) Diverse and highly recombinant anelloviruses associated with Weddell seals in Antarctica. Virus Evol 3:vex017
Morrell, Austin; Tallino, Savannah; Yu, Lei et al. (2017) The role of insufficient copper in lipid synthesis and fatty-liver disease. IUBMB Life 69:263-270
Rupp, Jonathan C; Locatelli, Manon; Grieser, Alexis et al. (2017) Host Cell Copper Transporters CTR1 and ATP7A are important for Influenza A virus replication. Virol J 14:11
Bhowmick, Saurav; Moore, Jeanette T; Kirschner, Daniel L et al. (2017) Arctic ground squirrel hippocampus tolerates oxygen glucose deprivation independent of hibernation season even when not hibernating and after ATP depletion, acidosis, and glutamate efflux. J Neurochem 142:160-170
Mitra, Swarup; Bastos, Cristiane P; Chesworth, Savanna et al. (2017) Strain and sex based characterization of behavioral expressions in non-induced compulsive-like mice. Physiol Behav 168:103-111

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