The Developmental Research Project Program will build on expertise developed in IDeA Network for Biomedical Excellence (INBRE) programs 1 and 2 to take advantage of Alaska, its unique environment, animal and human populations, and exposure to contaminants. The program will leverage our biomedical research focus on basic leading to translational research to improve overall health in the state focusing on """"""""One Health"""""""" (interactions of environment, animals, people). We will support new and existing INBRE faculty, expand the network of INBRE faculty, and move toward a translational research perspective. To do this, we will make seed grants available to all INBRE affiliates. Priority for funding will go to junior and newly-hired faculty who do not have independent funding. Priority will also go to faculty whose projects are translational and compliant with institutional animal or human subjects research guidelines and University of Alaska (UA)'s Responsible Conduct of Research. Faculty who have already received INBRE funding will only be considered for additional funding if they are addressing novel areas or collaborations. These seed grants will act as a bridge for faculty to obtain extramural funding. Grant proposals will be reviewed externally by an expert in the field, and faculty will have a chance to re-write their proposals to improve and resubmit them for internal review based on feedback. All INBRE faculty are strongly encouraged to have mentors. While mentors will serve a more traditional role for junior faculty, they will act as consultants or collaborators for senior faculty. Faculty will also be supported with research infrastructure. INBRES relies on outstanding resources by the institution, several of which INBRE supports via staffing, maintenance, and puchase of new equipment. Faculty will be supported in their professional development by promoting networking, scientific ethics and skills training, and opportunities for presentations at INBRES events. To expand our network and broaden the range of expertise in the program, we will recruit faculty from clinical domains at UA, which will foster new collaborations. While maintaining basic biomedical research capacity among faculty, we will expand the potential for them to take a translational approach with improved access to clinical resources.

Public Health Relevance

By supporting faculty through seed grants, research infrastructure, and professional development, we will increase their ability to compete for ROI grants and other extramural support. The network of faculty will be expanded to broaden our range of expertise, available resources, and clinical collaborations. Building a translaitional research capacity at UA is essential to understanding at-risk populations and improve health.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103395-14
Application #
8715974
Study Section
Special Emphasis Panel (ZGM1-TWD-7 (IN))
Project Start
2014-08-01
Project End
2019-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
14
Fiscal Year
2014
Total Cost
$1,178,296
Indirect Cost
Name
University of Alaska Fairbanks
Department
Type
DUNS #
615245164
City
Fairbanks
State
AK
Country
United States
Zip Code
99709
McGill, Colin M; Brown, Timothy J; Cheng, Yuan-Yin et al. (2018) Therapeutic Effect of Blueberry Extracts for Acute Myeloid Leukemia. Int J Biopharm Sci 1:
Smith, Lisa K; Kuhn, Thomas B; Chen, Jack et al. (2018) HHIV Associated Neurodegenerative Disorders: A New Perspective on the Role of Lipid Rafts in Gp120-Mediated Neurotoxicity. Curr HIV Res :
O'Brien, Kristin M; Crockett, Elizabeth L; Philip, Jacques et al. (2018) The loss of hemoglobin and myoglobin does not minimize oxidative stress in Antarctic icefishes. J Exp Biol 221:
Mitra, Swarup; Bult-Ito, Abel (2018) Attenuation of compulsive-like behavior by fluvoxamine in a non-induced mouse model of obsessive-compulsive disorder. Behav Pharmacol 29:299-305
Smeele, Zoe E; Burns, Jennifer M; Van Doorsaler, Koenraad et al. (2018) Diverse papillomaviruses identified in Weddell seals. J Gen Virol 99:549-557
Sticka, Kendra D; Schnurr, Theresia M; Jerome, Scott P et al. (2018) Exercise Increases Glucose Transporter-4 Levels on Peripheral Blood Mononuclear Cells. Med Sci Sports Exerc 50:938-944
O'Brien, Kristin M; Rix, Anna S; Egginton, Stuart et al. (2018) Cardiac mitochondrial metabolism may contribute to differences in thermal tolerance of red- and white-blooded Antarctic notothenioid fishes. J Exp Biol 221:
Hunter, Skyler; Maulik, Malabika; Scerbak, Courtney et al. (2018) Caenorhabditis Sieve: A Low-tech Instrument and Methodology for Sorting Small Multicellular Organisms. J Vis Exp :
Laughlin, Bernard W; Bailey, Isaac R; Rice, Sarah A et al. (2018) Precise Control of Target Temperature Using N6-Cyclohexyladenosine and Real-Time Control of Surface Temperature. Ther Hypothermia Temp Manag 8:108-116
Beltran, Roxanne S; Ruscher-Hill, Brandi; Kirkham, Amy L et al. (2018) An evaluation of three-dimensional photogrammetric and morphometric techniques for estimating volume and mass in Weddell seals Leptonychotes weddellii. PLoS One 13:e0189865

Showing the most recent 10 out of 114 publications