The main purpose of this IDeA Network of Biomedical Research Excellence (INBRE) proposal is to continue to enhance institutional capacity for biomedical and behavioral research in the state of Rhode Island. The University of Rhode Island (URI) is the lead institution, with six partner institutions forming the network. The administrative, bioinformatics, and centralized equipment facility cores at URI will coordinate the four central goals of the next phase: 1) Continue and improve faculty development and mentoring;2) Recruit and train undergraduate and graduate fellows;3) Provide access to state-of-the-art equipment and bioinformatics resources;and 4) Develop new initiatives and collaborations with other infrastructure development programs in the state. Achievement of these goals will be accomplished by collaborative efforts of 19 participating faculty investigators in the network who will carry out research and educational objectives in the focus areas of molecular toxicology, cell biology, and behavioral science. Newly created faculty development programs include research-based collaborative projects and education-based student training initiatives. Proposed projects will focus on a variety of heath-related issues including cancer, neurological diseases, drug metabolism, infectious diseases, tissue regeneration, and the effects of environmental toxins on human health. A new emphasis in bioinformatics, strengthened by increased material and personnel support, will substantially improve the data mining and processing capabilities of biomedical scientists in the state. A productive summer undergraduate research fellowship program, in which students are given rich experiential training in biomedical research methods and career counseling, will be continued. A new collaborative highschool outreach program is planned to provide hands-on research experience for area high school science teachers. It is anticipated that meeting these and other proposed objectives in the next phase of the Rl-INBRE program will continue to have a profound and measurable positive impact on the culture for biomedical and behavioral research and education in the State of Rhode Island.

Public Health Relevance

The proposed research will address a broad range of human health issues. Examples of these include: studies on causes and diagnosis of cancer, neurological diseases, metabolism of drugs and liver disease, parasitic human diseases, regeneration of damaged tissue, and impact of environmental toxins on human health.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103430-13
Application #
8465245
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Program Officer
Liu, Yanping
Project Start
2001-09-30
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
13
Fiscal Year
2013
Total Cost
$3,226,535
Indirect Cost
$349,167
Name
University of Rhode Island
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
144017188
City
Kingston
State
RI
Country
United States
Zip Code
02881
Xu, Jialin; Donepudi, Ajay C; More, Vijay R et al. (2015) Deficiency in Nrf2 transcription factor decreases adipose tissue mass and hepatic lipid accumulation in leptin-deficient mice. Obesity (Silver Spring) 23:335-44
Bellono, Nicholas W; Najera, Julia A; Oancea, Elena (2014) UV light activates a G?q/11-coupled phototransduction pathway in human melanocytes. J Gen Physiol 143:203-14
Brennan, Christopher M; Mazzucca, Nicholas Q; Mezoian, Taylor et al. (2014) Reduced heme levels underlie the exponential growth defect of the Shewanella oneidensis hfq mutant. PLoS One 9:e109879
Oh, Donghoon; Nasrolahi Shirazi, Amir; Northup, Kevin et al. (2014) Enhanced cellular uptake of short polyarginine peptides through fatty acylation and cyclization. Mol Pharm 11:2845-54
Nasrolahi Shirazi, Amir; Tiwari, Rakesh K; Oh, Donghoon et al. (2014) Cyclic peptide-selenium nanoparticles as drug transporters. Mol Pharm 11:3631-41
Lin, Qiushi; Aihara, Arihiro; Chung, Waihong et al. (2014) LRH1 promotes pancreatic cancer metastasis. Cancer Lett 350:15-24
Taylor, David L; Kutil, Nicholas J; Malek, Anna J et al. (2014) Mercury bioaccumulation in cartilaginous fishes from Southern New England coastal waters: contamination from a trophic ecology and human health perspective. Mar Environ Res 99:20-33
Motavallizadeh, Somayeh; Fallah-Tafti, Asal; Maleki, Saeedeh et al. (2014) Synthesis and evaluation of antiproliferative activity of substituted N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides. Tetrahedron Lett 55:373-375
Conicella, Alexander E; Fawzi, Nicolas L (2014) The C-terminal threonine of A?43 nucleates toxic aggregation via structural and dynamical changes in monomers and protofibrils. Biochemistry 53:3095-105
Hokeness, Kirsten; Kratch, Jacqueline; Nadolny, Christina et al. (2014) The effects of fungal volatile organic compounds on bone marrow stromal cells. Can J Microbiol 60:1-4

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