The long-term goal of this IDeA Network of Biomedical Research (INBRE) proposal is to enhance institutional capacity for biomedical research and training in the State of Rhode Island (Rl). The RI-INBRE Program is comprised of two research-intensive institutions (University of Rl and Brown University), and five primarily undergraduate institutions (PUIs) (Bryant University, Providence College, Rhode Island College, Roger Williams University, and Salve Regina University). The University of Rhode Island is the lead institution for the Program and will provide the administrative support, including planning, implementation, and assessment of the Bioinformatics, Centralized Research Facility, and Training Cores, as well as the development of thematic and collaborative research projects. Substantial progress has been made in achieving the long-term goals of the RI-INBRE program during the previous funding period, and the network is thriving. The present grant proposal is designed to seek 5-year renewal of NIH support for the research career development of the junior faculty, students, and postdoctoral fellows in the broad scientific thematic areas of Molecular Toxicology, Neuroscience, and Cancer research. While Toxicology has been a focus of the program from the beginning, Cancer and Neuroscience have evolved as the new areas which are consistent with the existing strengths and future plans of the network institutions.
The Specific Aims of the RI-INBRE Program for the next 5-year period are to: 1) improve the development of junior faculty members at URI and Brown into independent investigators, 2) assist PUI faculty in developing productive and sustainable student training programs, 3) strengthen collaborative research between PUI and URI/Brown faculty investigators, and 4) increase the participation of PUI students in research activities at URI and Brown. The overall goal is to further develop a statewide multidisciplinary research network that is productive, sustainable, and contributes to the development of science- and technology-based workforce for the State of Rl.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103430-14
Application #
8687068
Study Section
Special Emphasis Panel (ZGM1-TWD-7 (IN))
Program Officer
Liu, Yanping
Project Start
2001-09-30
Project End
2019-04-30
Budget Start
2014-06-01
Budget End
2015-04-30
Support Year
14
Fiscal Year
2014
Total Cost
$4,056,252
Indirect Cost
$866,833
Name
University of Rhode Island
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
144017188
City
Kingston
State
RI
Country
United States
Zip Code
02881
Chung, Waihong; Kim, Miran; de la Monte, Suzanne et al. (2016) Activation of signal transduction pathways during hepatic oncogenesis. Cancer Lett 370:1-9
Xu, Lifang; Cho, Bongsup P (2016) Conformational Insights into the Mechanism of Acetylaminofluorene-dG-Induced Frameshift Mutations in the NarI Mutational Hotspot. Chem Res Toxicol 29:213-26
Datta, Partha P; Kiesewetter, Matthew K (2016) Controlled Organocatalytic Ring-Opening Polymerization of ε-Thionocaprolactone. Macromolecules 49:774-780
Stevenson, James W; Conaty, Eliza A; Walsh, Rylie B et al. (2016) The Amyloid Precursor Protein of Alzheimer's Disease Clusters at the Organelle/Microtubule Interface on Organelles that Bind Microtubules in an ATP Dependent Manner. PLoS One 11:e0147808
Mamrak, Nicholas E; Shimamura, Akiko; Howlett, Niall G (2016) Recent discoveries in the molecular pathogenesis of the inherited bone marrow failure syndrome Fanconi anemia. Blood Rev :
Deering, Robert W; Chen, Jianwei; Sun, Jiadong et al. (2016) N-Acyl Dehydrotyrosines, Tyrosinase Inhibitors from the Marine Bacterium Thalassotalea sp. PP2-459. J Nat Prod 79:447-50
Stanley, Edward C; Azzinaro, Paul A; Vierra, David A et al. (2016) The Simple Chordate Ciona intestinalis Has a Reduced Complement of Genes Associated with Fanconi Anemia. Evol Bioinform Online 12:133-48
Wang, Zimeng; Cuddigan, Julie L; Gupta, Sweta K et al. (2016) Nanocomposite microparticles (nCmP) for the delivery of tacrolimus in the treatment of pulmonary arterial hypertension. Int J Pharm 512:305-13
Giulietti, Jennifer M; Tate, Patrick M; Cai, Ang et al. (2016) DNA-binding studies of the natural β-carboline eudistomin U. Bioorg Med Chem Lett 26:4705-8
Van Reet, Jennifer (2016) The Development of Representations of Pretend Object Substitutions. J Genet Psychol :1-12

Showing the most recent 10 out of 129 publications