West Virginia is a State that has had a historically low success rate in obtaining grant funds from the National Institutes of Health and has been designated as an IDeA state. In this renewal application, Marshall University (MU), in partnership with West Virginia University (WVU), will continue to build on the success of the West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE) to help develop biomedical research infrastructure and capacity throughout the network and provide biomedical research experiences for undergraduate and graduate students from the partner institutions. MU, in partnership with WVU, will continue to serve as lead institutions to a research network consisting of thirteen primarily undergraduate institutions (PUIs). The multi-disciplinary theme for WV-INBRE will be cellular and molecular biology with an emphasis on chronic disease (cancer, cardiovascular disease, diabetes and obesity-related illness). Supporting the activities of the network will be the Administrative, Bioinformatics and Genomics Cores which have been established to facilitate research progress, mentoring and training, and career development of investigators and students at the lead and partner institutions. Research in the network will be supported by major PUI research awards, Faculty Research Development Awards (FRDAs), and Center for Natural Products Research, Genomics Core and Chronic Disease Research Program pilot project awards. Ties to WV COBREs and the Health Sciences and Technology Academy (HSTA;an NIH-funded SEPA program) will be expanded and ties initiated to the WV IDeA-CTR Programs are proposed to provide research opportunities for PUI students, including the summer research program and HSTA graduate initiative, to help serve as a pipeline for these students into health-related research careers. HSTA high school science teachers and partner institution faculty fellows will also be provided summer research opportunities at the lead and network institutions. Through providing workshops, seminars, research training and mentoring, and access to state-of-the-art core facilities, WV-INBRE will help enhance the science and technology knowledge and skill base of the WV workforce.

Public Health Relevance

WV-INBRE supported research projects will investigate several major human health issues that are particularly prevalent in West Virginia, including cancer, cardiovascular disease, diabetes and obesity-related illness. An important aspect of WV-INBRE is directed toward enhancing the pipeline of undergraduate and graduate students choosing a career in the biomedical science research field.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103434-14
Application #
8686195
Study Section
Special Emphasis Panel (ZGM1-TWD-7 (IN))
Program Officer
Arora, Krishan
Project Start
2001-09-30
Project End
2019-07-31
Budget Start
2014-09-19
Budget End
2015-07-31
Support Year
14
Fiscal Year
2014
Total Cost
$3,790,279
Indirect Cost
$338,914
Name
Marshall University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
036156615
City
Huntington
State
WV
Country
United States
Zip Code
25701
Han, Alice A; Currie, Holly N; Loos, Matthew S et al. (2017) The impact of cytokine responses in the intra- and extracellular signaling network of a traumatic injury. Cytokine :
Rankin, Gary O; Tyree, Connor; Pope, Deborah et al. (2017) Role of Free Radicals and Biotransformation in Trichloronitrobenzene-Induced Nephrotoxicity In Vitro. Int J Mol Sci 18:
Wright, Kristeena Ray; Mitchell, Brenda; Santanam, Nalini (2017) Redox regulation of microRNAs in endometriosis-associated pain. Redox Biol 12:956-966
Haramizu, Satoshi; Asano, Shinichi; Butler, David C et al. (2017) Dietary resveratrol confers apoptotic resistance to oxidative stress in myoblasts. J Nutr Biochem 50:103-115
Bedenbaugh, Michelle N; O'Connell, Ryan C; Lopez, Justin A et al. (2017) Kisspeptin, GnRH, and ER? colocalise with nNOS neurones in prepubertal female sheep. J Neuroendocrinol :
Peng, Yin; Yan, Shun; Chen, Dongquan et al. (2017) Pdgfrb is a direct regulatory target of TGF? signaling in atrioventricular cushion mesenchymal cells. PLoS One 12:e0175791
Voronkova, Maria A; Luanpitpong, Sudjit; Rojanasakul, Liying Wang et al. (2017) SOX9 Regulates Cancer Stem-Like Properties and Metastatic Potential of Single-Walled Carbon Nanotube-Exposed Cells. Sci Rep 7:11653
Takahashi, Hideyuki; Suzuki, Yutaka; Mohamed, Junaith S et al. (2017) Epigallocatechin-3-gallate increases autophagy signaling in resting and unloaded plantaris muscles but selectively suppresses autophagy protein abundance in reloaded muscles of aged rats. Exp Gerontol 92:56-66
Pinti, Mark V; Hathaway, Quincy A; Hollander, John M (2017) Role of microRNA in metabolic shift during heart failure. Am J Physiol Heart Circ Physiol 312:H33-H45
Li, Bingyun; Webster, Thomas J (2017) Bacteria antibiotic resistance: New challenges and opportunities for implant-associated orthopedic infections. J Orthop Res :

Showing the most recent 10 out of 175 publications