West Virginia is a State that has had a historically low success rate in obtaining grant funds from the National Institutes of Health and has been designated as an IDeA state. In this renewal application, Marshall University (MU), in partnership with West Virginia University (WVU), will continue to build on the success of the West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE) to help develop biomedical research infrastructure and capacity throughout the network and provide biomedical research experiences for undergraduate and graduate students from the partner institutions. MU, in partnership with WVU, will continue to serve as lead institutions to a research network consisting of thirteen primarily undergraduate institutions (PUIs). The multi-disciplinary theme for WV-INBRE will be cellular and molecular biology with an emphasis on chronic disease (cancer, cardiovascular disease, diabetes and obesity-related illness). Supporting the activities of the network will be the Administrative, Bioinformatics and Genomics Cores which have been established to facilitate research progress, mentoring and training, and career development of investigators and students at the lead and partner institutions. Research in the network will be supported by major PUI research awards, Faculty Research Development Awards (FRDAs), and Center for Natural Products Research, Genomics Core and Chronic Disease Research Program pilot project awards. Ties to WV COBREs and the Health Sciences and Technology Academy (HSTA;an NIH-funded SEPA program) will be expanded and ties initiated to the WV IDeA-CTR Programs are proposed to provide research opportunities for PUI students, including the summer research program and HSTA graduate initiative, to help serve as a pipeline for these students into health-related research careers. HSTA high school science teachers and partner institution faculty fellows will also be provided summer research opportunities at the lead and network institutions. Through providing workshops, seminars, research training and mentoring, and access to state-of-the-art core facilities, WV-INBRE will help enhance the science and technology knowledge and skill base of the WV workforce.

Public Health Relevance

WV-INBRE supported research projects will investigate several major human health issues that are particularly prevalent in West Virginia, including cancer, cardiovascular disease, diabetes and obesity-related illness. An important aspect of WV-INBRE is directed toward enhancing the pipeline of undergraduate and graduate students choosing a career in the biomedical science research field.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-TWD-7 (IN))
Program Officer
Arora, Krishan
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Marshall University
Schools of Medicine
United States
Zip Code
Racine, Christopher; Ward, Dakota; Anestis, Dianne K et al. (2014) 3,4,5-Trichloroaniline nephrotoxicity in vitro: potential role of free radicals and renal biotransformation. Int J Mol Sci 15:20900-12
Magro, Albert; Magro, Alice; Shrestha, Sirish et al. (2014) Metalloproteinase dependent reduction of cell surface cluster determinants upon the induction of apoptosis. Int J Oncol 44:1539-50
Tomblin, Justin K; Salisbury, Travis B (2014) Insulin like growth factor 2 regulation of aryl hydrocarbon receptor in MCF-7 breast cancer cells. Biochem Biophys Res Commun 443:1092-6
Rottgen, Trey S; Fancher, Ibra S; Asano, Shinichi et al. (2014) Bisphenol A activates BK channels through effects on * and *1 subunits. Channels (Austin) 8:249-57
Luanpitpong, Sudjit; Wang, Liying; Stueckle, Todd A et al. (2014) Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation in carbon nanotube-driven tumorigenesis. Oncotarget 5:3541-54
Wenger, Sharon L; Hansroth, Joseph; Shackelford, Amy L (2014) Decreased telomere length in metaphase and interphase cells from newborns with trisomy 21. Gene 542:87
de Regt, Anna K; Yin, Yeshi; Withers, T Ryan et al. (2014) Overexpression of CupB5 activates alginate overproduction in Pseudomonas aeruginosa by a novel AlgW-dependent mechanism. Mol Microbiol 93:415-25
Withers, T Ryan; Yin, Yeshi; Yu, Hongwei D (2014) Identification and characterization of a novel inhibitor of alginate overproduction in Pseudomonas aeruginosa. Pathog Dis 70:185-8
Withers, T Ryan; Yin, Yeshi; Yu, Hongwei D (2014) Identification of novel genes associated with alginate production in Pseudomonas aeruginosa using mini-himar1 mariner transposon-mediated mutagenesis. J Vis Exp :
Valentovic, Monica A; Ball, John G; Brown, J Mike et al. (2014) Resveratrol attenuates cisplatin renal cortical cytotoxicity by modifying oxidative stress. Toxicol In Vitro 28:248-57

Showing the most recent 10 out of 29 publications