West Virginia is a State that has had a historically low success rate in obtaining grant funds from the National Institutes of Health and has been designated as an IDeA state. In this renewal application, Marshall University (MU), in partnership with West Virginia University (WVU), will continue to build on the success of the West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE) to help develop biomedical research infrastructure and capacity throughout the network and provide biomedical research experiences for undergraduate and graduate students from the partner institutions. MU, in partnership with WVU, will continue to serve as lead institutions to a research network consisting of thirteen primarily undergraduate institutions (PUIs). The multi-disciplinary theme for WV-INBRE will be cellular and molecular biology with an emphasis on chronic disease (cancer, cardiovascular disease, diabetes and obesity-related illness). Supporting the activities of the network will be the Administrative, Bioinformatics and Genomics Cores which have been established to facilitate research progress, mentoring and training, and career development of investigators and students at the lead and partner institutions. Research in the network will be supported by major PUI research awards, Faculty Research Development Awards (FRDAs), and Center for Natural Products Research, Genomics Core and Chronic Disease Research Program pilot project awards. Ties to WV COBREs and the Health Sciences and Technology Academy (HSTA;an NIH-funded SEPA program) will be expanded and ties initiated to the WV IDeA-CTR Programs are proposed to provide research opportunities for PUI students, including the summer research program and HSTA graduate initiative, to help serve as a pipeline for these students into health-related research careers. HSTA high school science teachers and partner institution faculty fellows will also be provided summer research opportunities at the lead and network institutions. Through providing workshops, seminars, research training and mentoring, and access to state-of-the-art core facilities, WV-INBRE will help enhance the science and technology knowledge and skill base of the WV workforce.
WV-INBRE supported research projects will investigate several major human health issues that are particularly prevalent in West Virginia, including cancer, cardiovascular disease, diabetes and obesity-related illness. An important aspect of WV-INBRE is directed toward enhancing the pipeline of undergraduate and graduate students choosing a career in the biomedical science research field.
|Schmitt, Deanna M; Connolly, Kristie L; Jerse, Ann E et al. (2016) Antibacterial activity of resazurin-based compounds against Neisseria gonorrhoeae in vitro and in vivo. Int J Antimicrob Agents 48:367-72|
|Barbier, Mariette; Damron, F Heath (2016) Rainbow Vectors for Broad-Range Bacterial Fluorescence Labeling. PLoS One 11:e0146827|
|Moses, Blake S; Evans, Rebecca; Slone, William L et al. (2016) Bone Marrow Microenvironment Niche Regulates miR-221/222 in Acute Lymphoblastic Leukemia. Mol Cancer Res 14:909-919|
|Gao, Ying; Rankin, Gary O; Tu, Youying et al. (2016) Theaflavin-3, 3'-digallate decreases human ovarian carcinoma OVCAR-3 cell-induced angiogenesis via Akt and Notch-1 pathways, not via MAPK pathways. Int J Oncol 48:281-92|
|Noblet, Jillian N; Goodwill, Adam G; Sassoon, Daniel J et al. (2016) Leptin augments coronary vasoconstriction and smooth muscle proliferation via a Rho-kinase-dependent pathway. Basic Res Cardiol 111:25|
|Zdilla, Matthew J; Pancake, Alex R; Lambert, H Wayne (2016) Morphometrics of the Anterior Belly and Intermediate Tendon of the Digastric Muscle: Sexual Dimorphism and Implications for Surgery. J Craniofac Surg 27:1321-6|
|Berzingi, Seher; Newman, Mackenzie; Yu, Han-Gang (2016) Altering bioelectricity on inhibition of human breast cancer cells. Cancer Cell Int 16:72|
|Slone, William L; Moses, Blake S; Hare, Ian et al. (2016) BCL6 modulation of acute lymphoblastic leukemia response to chemotherapy. Oncotarget 7:23439-53|
|Bukeirat, Mimi; Sarkar, Saumyendra N; Hu, Heng et al. (2016) MiR-34a regulates blood-brain barrier permeability and mitochondrial function by targeting cytochrome c. J Cereb Blood Flow Metab 36:387-92|
|Maurer, Megan M; Donohoe, Gregory C; Maleki, Hossein et al. (2016) Comparative plasma proteomic studies of pulmonary TiO2 nanoparticle exposure in rats using liquid chromatography tandem mass spectrometry. J Proteomics 130:85-93|
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