Abstract

The Bioinformatics Core (BC) works with the WV-INBRE Genomics Core (GC) at Marshall University (MU) and West Virginia University (WVU) GC to deliver integrated analysis of Next Generation Sequencing (NGS) and microarray data sets. NGS and microarray data analysis are and will be provided to network investigators as a full service from planning and experimental design, through DNA/RNA Quality Control (QC), wet lab experimentation with Quality Analysis (QA), data analysis and interpretation, to delivery of results, and discussion of their significance and additional methods of analysis. Under our service model, investigators must meet with BC and GC staff to discuss experimental design, methods of analysis, expected outcomes and costs prior to the initiation of any experimentation (full description of service plan is provided under section 11(3)). A separate description of the GC as an optional Core is provided as part of this application. Members of the BC and the GC work together on most of these services.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103434-15
Application #
8928226
Study Section
Special Emphasis Panel (ZGM1-TWD-7)
Project Start
Project End
Budget Start
2015-08-01
Budget End
2016-07-31
Support Year
15
Fiscal Year
2015
Total Cost
$330,722
Indirect Cost
$15,063

  Institution

Name
Marshall University
Department
Type
DUNS #
036156615
City
Huntington
State
WV
Country
United States
Zip Code
25755

  Publications

Zhang, Shichao; Xing, Malcolm M Q; Li, Bingyun (2018) Capsule Integrated Polypeptide Multilayer Films for Effective pH-Responsive Multiple Drug Co-Delivery. ACS Appl Mater Interfaces :
Shepherd, Danielle L; Hathaway, Quincy A; Nichols, Cody E et al. (2018) Mitochondrial proteome disruption in the diabetic heart through targeted epigenetic regulation at the mitochondrial heat shock protein 70 (mtHsp70) nuclear locus. J Mol Cell Cardiol 119:104-115
Zhang, Yu; Chen, Shiguo; Wei, Chaoyang et al. (2018) Flavonoids from Chinese bayberry leaves induced apoptosis and G1 cell cycle arrest via Erk pathway in ovarian cancer cells. Eur J Med Chem 147:218-226
Han, Alice A; Currie, Holly N; Loos, Matthew S et al. (2018) The impact of cytokine responses in the intra- and extracellular signaling network of a traumatic injury. Cytokine 106:136-147
McAleer, Jeremy P; Fan, Jun; Roar, Bryanna et al. (2018) Cytokine Regulation in Human CD4 T Cells by the Aryl Hydrocarbon Receptor and Gq-Coupled Receptors. Sci Rep 8:10954
Zhang, Yu; Chen, Shiguo; Wei, Chaoyang et al. (2018) Dietary Compound Proanthocyanidins from Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves inhibit angiogenesis and regulate cell cycle of cisplatin-resistant ovarian cancer cells via targeting Akt pathway. J Funct Foods 40:573-581
Perla, Venu; Nadimi, Marjan; Reddy, Rishi et al. (2018) Effect of ghost pepper on cell proliferation, apoptosis, senescence and global proteomic profile in human renal adenocarcinoma cells. PLoS One 13:e0206183
Boehm, Dylan T; Hall, Jesse M; Wong, Ting Y et al. (2018) Evaluation of Adenylate Cyclase Toxoid Antigen in Acellular Pertussis Vaccines by Using a Bordetella pertussis Challenge Model in Mice. Infect Immun 86:
Zhang, Yu; Chen, Shiguo; Wei, Chaoyang et al. (2018) Dietary compound proanthocyanidins from Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves attenuate chemotherapy-resistant ovarian cancer stem cell traits via targeting the Wnt/?-catenin signaling pathway and inducing G1 cell cycle arrest. Food Funct 9:525-533
Zdilla, Matthew J; Russell, Michelle L; Koons, Aaron W (2018) Infraorbital foramen location in the pediatric population: A guide for infraorbital nerve block. Paediatr Anaesth 28:697-702

Showing the most recent 10 out of 207 publications