The Kentucky INBRE serves a statewide mission to build infrastructure and capacity for biomedical and health-related research and training as well as for bioinformatics. In this application, the University of Louisville is partnered with the University of Kentucky, Berea College, Eastern Kentucky University, Morehead State University, Northern Kentucky University and Western Kentucky University to continue the development of our collaborative network. The goals of our network are to build competitive research and training programs in the biomedical and health sciences, particularly in the fields of genomics and neuroscience, as well as to build competitive bioinformatics programs. These efforts will lead to improved prospects for career development for our undergraduate and graduate students, postdoctoral fellows, and young faculty investigators. In this application, we propose mechanisms to sustain as well as grow the competitive research component of this program as this aspect is viewed as critical to the establishment of our training and career development activities. This will include support for teaching-postdoctoral fellows and research associates for existing investigators, program support for new research investigators, and for the initiation of new developmental research projects. For bioinformatics, we aim to support projects with the potential for development as competitive independent, and/or collaborative, proposals. To enhance the career development aspects for faculty, postdoctoral fellows and prospective researchers in our program we will develop a mentoring team of proven investigators to provide workshops on grant writing skills and disseminate materials related to best practices. We intend to continue partial funding of our centralized microarray facility which is essential to the development of genomics-based research projects at this and other institutions, and we will continue to develop initiatives in aid of our growing proteomics research base. We propose to establish a new, community-based participatory research core. As a first step, this core will establish web-accessible de-identified electronic health records for health care organizations in rural Kentucky. Health information gained from this activity will be used to inform the future development of our undergraduate and graduate curriculum content and our biomedical research goals. The infrastructure will also be used to enable the patient community to indicate their interest in participating in relevant clinical research trials. In summary, our strategy is designed to strengthen and build our infrastructure and capacity and to build an innovative next generation network.

Public Health Relevance

Health information gained from the development of a community-based participatory core will be used to inform the future development of our undergraduate and graduate curriculum content and our biomedical research goals. The infrastructure will also be used to enable the patient community to indicate their interest in participating in relevant clinical research trials.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
8P20GM103436-12
Application #
8263762
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Program Officer
Canto, Maria Teresa
Project Start
2001-09-30
Project End
2014-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
12
Fiscal Year
2012
Total Cost
$2,953,153
Indirect Cost
$274,409
Name
University of Louisville
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292
Ebersole, J L; Kirakodu, S; Novak, M J et al. (2016) Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa. Mol Oral Microbiol 31:18-32
Yates, Justin R; Breitenstein, Kerry A; Gunkel, Benjamin T et al. (2016) Effects of NMDA receptor antagonists on probability discounting depend on the order of probability presentation. Pharmacol Biochem Behav 150-151:31-38
Cieply, Benjamin; Park, Juw Won; Nakauka-Ddamba, Angela et al. (2016) Multiphasic and Dynamic Changes in Alternative Splicing during Induction of Pluripotency Are Coordinated by Numerous RNA-Binding Proteins. Cell Rep 15:247-55
Bowling, Bethany V; Schultheis, Patrick J; Strome, Erin D (2016) Implementation and assessment of a yeast orphan gene research project: involving undergraduates in authentic research experiences and progressing our understanding of uncharacterized open reading frames. Yeast 33:43-53
Monroe, J David; Manning, Dustin P; Uribe, Phillip M et al. (2016) Hearing sensitivity differs between zebrafish lines used in auditory research. Hear Res 341:220-231
Matveeva, Elena; Maiorano, John; Zhang, Qingyang et al. (2016) Involvement of PARP1 in the regulation of alternative splicing. Cell Discov 2:15046
Malloy, Cole A; Ritter, Kyle; Robinson, Jonathan et al. (2016) Pharmacological identification of cholinergic receptor subtypes on Drosophila melanogaster larval heart. J Comp Physiol B 186:45-57
Smith, Michael E (2016) Relationship Between Hair Cell Loss and Hearing Loss in Fishes. Adv Exp Med Biol 875:1067-74
Harris, Jesse A; Carlson, Katy (2016) Keep it local (and final): Remnant preferences in "let alone" ellipsis. Q J Exp Psychol (Hove) 69:1278-301
Peveler, Willard W; Sanders, Gabe; Marczinski, Cecile et al. (2016) Effects of energy drinks on economy and cardiovascular measures. J Strength Cond Res :

Showing the most recent 10 out of 121 publications