In this COBRE renewal application, we will further develop a world-class center of excellence in vascular biology at the Oklahoma Medical Research Foundation (OMRF) and its partner institutions in Oklahoma. In the initial funding period, we fostered vascular biology research through a multidisciplinary approach. We supported methods development in new core facilities that enhanced the research projects. Mentoring launched the independent careers of outstanding junior investigators, who brought innovative new technologies to OMRF, made possible new multi-investigator NIH grants, and helped us recruit a new cadre of outstanding young investigators with great promise. To date, our nine COBRE project leaders have published 63 papers and received three R01/P01 grants, an NSF grant, and many other grants as PI or project leader. In this renewal, we will exploit synergistic interactions in the Cardiovascular Biology and Free Radical Biology and Aging Programs at OMRF to further develop our vascular biology center. We will support projects of four new junior investigators and one early-to-mid-career investigator. These projects address complementary themes in vascular development, atherosclerosis, and inflammation. Further methods development in microscopy, small animal imaging, and flow cytometry/cell sorting core facilities will drive progress in the projects. We will also support selected pilot projects in promising new areas of vascular biology. Mentoring will emphasize the use of multiple disciplines to creatively address research problems. The strategy encourages collaborative research that enables investigators to compete successfully for dual-or multi-investigator research grants. This will catalyze further expansion of a self-sustaining research center in vascular biology of the highest caliber.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103441-09
Application #
8460844
Study Section
Special Emphasis Panel (ZRR1-CR-B (01))
Program Officer
Canto, Maria Teresa
Project Start
2003-09-01
Project End
2015-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
9
Fiscal Year
2013
Total Cost
$2,411,133
Indirect Cost
$985,302
Name
Oklahoma Medical Research Foundation
Department
Type
DUNS #
077333797
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104
Griffin, Timothy M; Humphries, Kenneth M; Kinter, Michael et al. (2016) Nutrient sensing and utilization: Getting to the heart of metabolic flexibility. Biochimie 124:74-83
Geng, Xin; Cha, Boksik; Mahamud, Md Riaj et al. (2016) Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development. Dev Biol 409:218-33
Fu, Yao; Kinter, Michael; Hudson, Joanna et al. (2016) Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis. Arthritis Rheumatol 68:1887-98
Bergstrom, Kirk; Liu, Xiaowei; Zhao, Yiming et al. (2016) Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice. Gastroenterology 151:152-164.e11
Fu, Yao; Huebner, Janet L; Kraus, Virginia B et al. (2016) Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats. J Gerontol A Biol Sci Med Sci 71:1131-40
Herlea-Pana, Oana; Yao, Longbiao; Heuser-Baker, Janet et al. (2015) Chemokine receptors CXCR2 and CX3CR1 differentially regulate functional responses of bone-marrow endothelial progenitors during atherosclerotic plaque regression. Cardiovasc Res 106:324-37
He, Chaoyong; Medley, Shayna C; Hu, Taishan et al. (2015) PDGFRβ signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis. Nat Commun 6:7770
Sweet, Daniel T; Jiménez, Juan M; Chang, Jeremy et al. (2015) Lymph flow regulates collecting lymphatic vessel maturation in vivo. J Clin Invest 125:2995-3007
Astarita, Jillian L; Cremasco, Viviana; Fu, Jianxin et al. (2015) The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture. Nat Immunol 16:75-84
Wiley, Mandi M; Muthukumar, Vijay; Griffin, Timothy M et al. (2015) SWI/SNF chromatin-remodeling enzymes Brahma-related gene 1 (BRG1) and Brahma (BRM) are dispensable in multiple models of postnatal angiogenesis but are required for vascular integrity in infant mice. J Am Heart Assoc 4:

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