Abstract

The North Dakota INBRE has succeeded beyond all reasonable expectations in fulfilling the IDeA program's goal of establishing an undergraduate research culture in the State's primarily undergraduate institutions (PUIs). Furthermore, each of the four PUIs in North Dakota have developed a culture capable of sustaining and enhancing these INBRE-sponsored undergraduate research programs. The ND INBRE has also advanced these efforts into the Native American community with the successful establishment of a genetics-based, undergraduate-driven research program on pre-eclampsia at Turtle Mountain Community College. An introduction to research course has recently been developed by Native American faculty for the Cankdeska Cikana Community College, the ND INBRE has taken the lead in funding and stabilizing the K-12 portion of the Indians into Medicine Program. This program produces over 25% of the Nation's Native American physicians. Evidence is accumulating that the ND INBRE undergraduate research programs are having an impact on the pipeline of undergraduates entering biomedical research. A focused goal of ND INBRE in the coming year will be to develop bioinformatics beyond wire and library resources.
Aim 1 : To Continue to Support and Enhance the Outstanding Undergraduate Research Programs.
Aim 2 : To Continue to Support and Expand Efforts to Engage Native American Students in Undergraduate Research.
Aim 3 : To Continue to Support the INMED Summer Academy and Pathways Program.
Aim 4 : To Continue Support for a Previously Established Proteomics Core Facility and Continue Development of a Metal Analysis Core. To Initiate a Cutting-Edge Bioinformatics Program.
Aim 5 : To Establish a Community Based Participatory Research Core.
Aim 6 : The Development of a Network that Encourages Scientific and Professional Interactions Among the Partners and Enhances the Pipeline of Students Entering Biomedical and Behavioral Research.

Public Health Relevance

The partners of the ND INBRE can state that all undergraduates in the State's PUIs, that were qualified and desired an undergraduate research experience in science, have been afforded this career-building opportunity. Furthermore, each of the four PUIs in North Dakota have developed a culture capable of sustaining and enhancing these INBRE-sponsored undergraduate research programs, all of which offer year-long, in-institution, participation in the undergraduate research enterprise.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103442-13
Application #
8516539
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Program Officer
Caldwell, Sheila
Project Start
2001-09-24
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
13
Fiscal Year
2013
Total Cost
$3,040,751
Indirect Cost
$205,174

  Institution

Name
University of North Dakota
Department
Pathology
Type
Schools of Medicine
DUNS #
102280781
City
Grand Forks
State
ND
Country
United States
Zip Code
58202

  Publications

Shabani, Shkelzen; Schmidt, Bryan; Ghimire, Bikalpa et al. (2018) Depression-like symptoms of withdrawal in a genetic mouse model of binge methamphetamine intake. Genes Brain Behav :e12533
Jondle, Christopher N; Gupta, Kuldeep; Mishra, Bibhuti B et al. (2018) Klebsiella pneumoniae infection of murine neutrophils impairs their efferocytic clearance by modulating cell death machinery. PLoS Pathog 14:e1007338
Basson, Marc D; Wang, Qinggang; Chaturvedi, Lakshmi S et al. (2018) Schlafen 12 Interaction with SerpinB12 and Deubiquitylases Drives Human Enterocyte Differentiation. Cell Physiol Biochem 48:1274-1290
Selya, Arielle S; Thapa, Sunita; Mehta, Gaurav (2018) Earlier smoking after waking and the risk of asthma: a cross-sectional study using NHANES data. BMC Pulm Med 18:102
Sun, Yuyang; Sukumaran, Pramod; Selvaraj, Senthil et al. (2018) TRPM2 Promotes Neurotoxin MPP+/MPTP-Induced Cell Death. Mol Neurobiol 55:409-420
Claw, Katrina G; Anderson, Matthew Z; Begay, Rene L et al. (2018) A framework for enhancing ethical genomic research with Indigenous communities. Nat Commun 9:2957
Quenum Zangbede, Fredice O; Chauhan, Arun; Sharma, Jyotika et al. (2018) Galectin-3 in M2 Macrophages Plays a Protective Role in Resolution of Neuropathology in Brain Parasitic Infection by Regulating Neutrophil Turnover. J Neurosci 38:6737-6750
Chauhan, Arun; Sun, Yuyang; Sukumaran, Pramod et al. (2018) M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry. iScience 8:85-102
Sukumaran, Pramod; Sun, Yuyang; Antonson, Neil et al. (2018) Dopaminergic neurotoxins induce cell death by attenuating NF-?B-mediated regulation of TRPC1 expression and autophagy. FASEB J 32:1640-1652
Hovde, Moriah J; Larson, Garret H; Vaughan, Roxanne A et al. (2018) Model systems for analysis of dopamine transporter function and regulation. Neurochem Int :

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