The overall objective for this COBRE is to build upon the substantial accomplishments of the previous funding period and continue efforts toward establishing a Center for Experimental Infectious Disease Research (CEIDR) led by the Louisiana State University-Baton Rouge (LSU-BR) School of Veterinary Medicine, (SVM) in a strategic alliance with the Tulane National Primate Research Center (TNPRC),and the LSU-BR College of Basic Sciences (BASC). Accomplishments by junior investigators (Jls) recruited during the last funding period (2003-2008) includes the award of 4R01, 2R21, 2K22,1K01 and 1 NIH-R01- subcontract, as well as competitive funding from sources other than NIH. Two new Jls are very close to be funded with ROI grants. Importantly, the institutions were awarded a NIH T32 postdoctoral training grant for veterinarians and a NIH T35 summer training grant for veterinary students. The COBRE will be administered by senior NIH funded investigators. Dr. K. G. Kousoulas (LSU-SVM) and Dr. A. A. Lackner, (TNPRC). The proposed program for years 6-10 of the COBRE encompass four integrated research projects under the direction of new junior investigators working on infectious diseases. The new projects are;1. Host mediators of mycobacterium tuberculosis (MTB) immunopathology (Deepak Kaushal;TNPRC);2. Borrelial evasion of innate and adaptive immunity (Fangting Liang, SVM);3. Molecular determinants of rickettsial pathogens in tick hosts (Kevin Macaluso, SVM);4) The role of humoral immune responses in control of SIV replication and pathogenesis (Bapi Pahar, TNPRC). Enhancement of the research infrastructure will be achieved by the formation of a Molecular Immunopathology (MIP) Core Laboratory as a consortium of existing LSU-SVM Centralized Laboratories. Individual Jls will be mentored by three NIH-experienced senior mentors who collectively will constitute the internal advisory committee (IAC) of the Center. Future development of the Center will be achieved through the addition of 4-6 new investigators at LSU and TNPRC within the next three years, as well as the hiring of two senior investigators. It is anticipated that research outcomes will be translated to vaccines and other treatment modalities for ameliorating human and animal diseases.

Public Health Relevance

The proposed research is focused on finding new ways to understand and combat infectious diseases including AIDS, Lyme Disease, Tubercullosis and mosquito borne diseases. The work will produce new diagnostics and vacines to ameliorate these diseases.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Liu, Yanping
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Louisiana State University A&M Col Baton Rouge
Veterinary Sciences
Schools of Veterinary Medicine
Baton Rouge
United States
Zip Code
Allen, Sariah J; Mott, Kevin R; Matsuura, Yoshiharu et al. (2014) Binding of HSV-1 glycoprotein K (gK) to signal peptide peptidase (SPP) is required for virus infectivity. PLoS One 9:e85360
Pan, Diganta; Kenway-Lynch, Carys S; Lala, Wendy et al. (2014) Lack of interleukin-10-mediated anti-inflammatory signals and upregulated interferon gamma production are linked to increased intestinal epithelial cell apoptosis in pathogenic simian immunodeficiency virus infection. J Virol 88:13015-28
Saied, Ahmad A; Chouljenko, V N; Subramanian, Ramesh et al. (2014) A replication competent HSV-1(McKrae) with a mutation in the amino-terminus of glycoprotein K (gK) is unable to infect mouse trigeminal ganglia after cornea infection. Curr Eye Res 39:596-603
Mores, Christopher N; Christofferson, Rebecca C; Davidson, Silas A (2014) The role of the mosquito in a dengue human infection model. J Infect Dis 209 Suppl 2:S71-8
Kim, In-Joong; Saied, Ahmad A; Chouljenko, Vladimir N et al. (2014) Functional hierarchy of herpes simplex virus type-1 membrane proteins in corneal infection and virus transmission to ganglionic neurons. Curr Eye Res 39:1169-77
McCracken, M K; Christofferson, R C; Chisenhall, D M et al. (2014) Analysis of early dengue virus infection in mice as modulated by Aedes aegypti probing. J Virol 88:1881-9
Chisenhall, Daniel M; Londono, Berlin L; Christofferson, Rebecca C et al. (2014) Effect of dengue-2 virus infection on protein expression in the salivary glands of Aedes aegypti mosquitoes. Am J Trop Med Hyg 90:431-7
Chisenhall, Daniel M; Christofferson, Rebecca C; McCracken, Michael K et al. (2014) Infection with dengue-2 virus alters proteins in naturally expectorated saliva of Aedes aegypti mosquitoes. Parasit Vectors 7:252
Hagge, Deanna A; Scollard, David M; Ray, Nashone A et al. (2014) IL-10 and NOS2 modulate antigen-specific reactivity and nerve infiltration by T cells in experimental leprosy. PLoS Negl Trop Dis 8:e3149
Jambunathan, Nithya; Chouljenko, Dmitry; Desai, Prashant et al. (2014) Herpes simplex virus 1 protein UL37 interacts with viral glycoprotein gK and membrane protein UL20 and functions in cytoplasmic virion envelopment. J Virol 88:5927-35

Showing the most recent 10 out of 22 publications