Core A will continue to provide scientific, fiscal, administrative, and logistic oversight to all aspects of the Center. As before. Core personnel will facilitate communication among investigators and the sharing of reagents, tools, specimens, and data to ensure appropriate allocation and effective use of Center funds. The Core will also continue to: provide clerical support; coordinate interactions between facility cores and research projects; organize regular investigator meetings and; provide biostatistical support. In addition to these functions, the Core will develop and implement a clear path for transition to and attainment of independent status and for the continued career development of early career investigators . The Core will provide leadership and administrative support needed to maintain the thematic focus of the Center and to achieve Center goal. It will provide mentorshp to early-career investigaotrs by expanding curernt mentoring activitis, while continued to provide personalized mentoring. Core personnel will encourage the exploratoin of new research avenues and phase out unpromising resarch and maximize the intellectual environment of the Center. The Core will also provide statistical support to assist in study design and analysis and help in developing grant proposals. It will monitor evaluate overall Center progress in achieving specific milestones. Core personel will prepare annual scientific reports and financial statements and plan and organize symposia, seminars and regulary-scheduled meetings. They will invite prominent scientists to present seminars and interact with Center members and communiate with University and NIH officials to report progress and discuss Center related issues. In consultation with the external and internal advisory committee, the Program Director will recruit new faculty to replace graduating COBRE investigators and if required increase the critical mass of investiagtors working in the Center. If required, Core A will adopt remedial measures for Principal Investigators who fail to satisfactory review by the External Advisory Committee. The Core will also maintain a Center Website and faciliate the dissemination of information about Center activities as well as diabetes and obesity.

Public Health Relevance

The Core will provide administrative support to the Diabetes and Obesity Center at the University of Louisville and therefore contribute to the development of new and effective strategies for prevention and treatment of diabetes and obesity research by facilitating research in this area and by providing mentoring and training to the next generation of scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
3P20GM103492-09S1
Application #
9329560
Study Section
Special Emphasis Panel (ZGM1-TWD-Y)
Program Officer
Canto, Maria Teresa
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
9
Fiscal Year
2016
Total Cost
$328,504
Indirect Cost
$63,054
Name
University of Louisville
Department
Type
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40208
Zafar, Nagma; Krishnasamy, Sathya S; Shah, Jasmit et al. (2018) Circulating angiogenic stem cells in type 2 diabetes are associated with glycemic control and endothelial dysfunction. PLoS One 13:e0205851
Hoetker, David; Chung, Weiliang; Zhang, Deqing et al. (2018) Exercise alters and ?-alanine combined with exercise augments histidyl dipeptide levels and scavenges lipid peroxidation products in human skeletal muscle. J Appl Physiol (1985) :
Baba, Shahid P; Bhatnagar, Aruni (2018) ROLE OF THIOLS IN OXIDATIVE STRESS. Curr Opin Toxicol 7:133-139
Abplanalp, Wesley; Wickramasinghe, Nalinie S; Sithu, Srinivas D et al. (2018) Benzene exposure induces insulin resistance in mice. Toxicol Sci :
Nystoriak, Matthew A; Bhatnagar, Aruni (2018) Cardiovascular Effects and Benefits of Exercise. Front Cardiovasc Med 5:135
Nystoriak, Matthew A; Navedo, Manuel F (2018) Regulation of microvascular function by voltage-gated potassium channels: New tricks for an ""ancient"" dog. Microcirculation 25:
Haberzettl, Petra; Conklin, Daniel J; Abplanalp, Wesley T et al. (2018) Inhalation of Fine Particulate Matter Impairs Endothelial Progenitor Cell Function Via Pulmonary Oxidative Stress. Arterioscler Thromb Vasc Biol 38:131-142
Mehra, Parul; Guo, Yiru; Nong, Yibing et al. (2018) Cardiac mesenchymal cells from diabetic mice are ineffective for cell therapy-mediated myocardial repair. Basic Res Cardiol 113:46
Ghosh Dastidar, Shubha; Jagatheesan, Ganapathy; Haberzettl, Petra et al. (2018) Glutathione S-transferase P Deficiency Induces Glucose Intolerance via JNK-dependent Enhancement of Hepatic Gluconeogenesis. Am J Physiol Endocrinol Metab :
Baba, Shahid P; Zhang, Deqing; Singh, Mahavir et al. (2018) Deficiency of aldose reductase exacerbates early pressure overload-induced cardiac dysfunction and autophagy in mice. J Mol Cell Cardiol 118:183-192

Showing the most recent 10 out of 110 publications