The objective of this COBRE renewal application is to continue to develop the research careers of promising junior investigators In Cancer Genetics and to build core Programmatic strength in this area. Career development will utilize a strong core of research mentors who will provide career development advice as well as sound practical advice on scientific development and lab management. The five projects in this COBRE focus one several overlapping themes that contribute to our understanding of genetic instability, cellular inflammation, and the cell's responses to these factors. All but one of the proposals specifically focus on mouse models for studying cancer, and all projects have a high translational relevance. An internal advisory committee composed of mentors and core directors for this COBRE are all strongly committed to the program, and have outstanding research and mentoring records. In addition, a prominent board of external advisors with outstanding research careers and track records of career development for junior scientists will participate in both the guidance and evaluation of the progress of the junior investigators and the COBRE program itself. Career development will involve a series of program meetings, exposure to didactic grant-writing sessions, and seminars to develop a highly collaborative environment for both the junior faculty, as well as other members of the Louisiana Cancer Research Consortium (LCRC). The COBRE also provides outstanding core facility development for our scientists to make new experiments available to them. The LCRC provides an outstanding interdisiplinary and interinstitutional environment for cancer research involving Tulane Univerisy, LSU Heath Sciences Center and Xavier University. The LCRC is funded by a long-term state tobacco tax with the express goal of competing for NCI designation as a cancer center in New Orleans. The LCRC provides outstanding recruitment in the next few years, a new building dedicated to the LCRC and a series of well-operated core facilities. This COBRE represents the centerpiece of the LCRC and contributed strongly to our rebuilding post-Katrina as well as providing the framework that helps guide mentoring and development throughout the LCRC.

Public Health Relevance

This COBRE has been responsible for the success of a number of our young faculty obtaining their first NIH R01 funding and we believe we are poised for even more growth in the renewal. This will greatly enhance the research funding base and mentoring pool in Southeastern Louisiana. In addition, the scientific programs and cores described here provide outstanding and highly translational projects aimed at combating cancer.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Gorospe, Rafael
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Tulane University
Public Health & Prev Medicine
Schools of Public Health
New Orleans
United States
Zip Code
Strong, Michael J; Baddoo, Melody; Nanbo, Asuka et al. (2014) Comprehensive high-throughput RNA sequencing analysis reveals contamination of multiple nasopharyngeal carcinoma cell lines with HeLa cell genomes. J Virol 88:10696-704
Kines, Kristine J; Sokolowski, Mark; deHaro, Dawn L et al. (2014) Potential for genomic instability associated with retrotranspositionally-incompetent L1 loci. Nucleic Acids Res 42:10488-502
Yoon, Sun-Ok; Zapata, Mariana C; Singh, Akannsha et al. (2014) Gamma secretase inhibitors enhance vincristine-induced apoptosis in T-ALL in a NOTCH-independent manner. Apoptosis 19:1616-26
Martin, Elizabeth C; Krebs, Adrienne E; Burks, Hope E et al. (2014) miR-155 induced transcriptome changes in the MCF-7 breast cancer cell line leads to enhanced mitogen activated protein kinase signaling. Genes Cancer 5:353-64
Ge, Dongxia; Zhang, Qing-Song; Zabaleta, Jovanny et al. (2014) Doublecortin may play a role in defining chondrocyte phenotype. Int J Mol Sci 15:6941-60
Zhang, Qiuyang; Liu, Sen; Zhang, Qingsong et al. (2014) Interleukin-17 promotes development of castration-resistant prostate cancer potentially through creating an immunotolerant and pro-angiogenic tumor microenvironment. Prostate 74:869-79
Terragni, Jolyon; Zhang, Guoqiang; Sun, Zhiyi et al. (2014) Notch signaling genes: myogenic DNA hypomethylation and 5-hydroxymethylcytosine. Epigenetics 9:842-50
Xu, Beibei; Guenther, James F; Pociask, Derek A et al. (2014) Promotion of lung tumor growth by interleukin-17. Am J Physiol Lung Cell Mol Physiol 307:L497-508
Li, Qingli; Liu, Lunxu; Zhang, Qiuyang et al. (2014) Interleukin-17 Indirectly Promotes M2 Macrophage Differentiation through Stimulation of COX-2/PGE2 Pathway in the Cancer Cells. Cancer Res Treat 46:297-306
Singh, Akannsha; Zapata, Mariana C; Choi, Yong Sung et al. (2014) GSI promotes vincristine-induced apoptosis by enhancing multi-polar spindle formation. Cell Cycle 13:157-66

Showing the most recent 10 out of 35 publications