Five years of funding are requested to further develop a Center of Biomedical Research Excellence at Kansas University Medical Center with a focus on Nuclear Receptors and their Role in Liver Health and Disease. Five talented new faculty who share this research interest were selected with the goal of helping them become funded, independent investigators. A PI, co-PI, an internal advisory committee of experienced senior faculty and an external advisory committee of prominent scientists have been assembled to mentor them to this goal. The Center will also help provide infrastructure and equipment to supplement the research environment. Ultimately, through the achievement of these initial goals, the final long-range goal is the submission of a program project grant application. An important feature of this Proposal is that for each initial junior faculty member, two co-mentors have been assigned and individual mentoring plans and timetables have been developed. Central features of the mentoring plans include ongoing critical evaluation of the research project by the mentors and IAC, semiannual conferences with EAC members, and special training on statistics, manuscript and grant writing, and teaching. The first 6 junior faculty assigned to this COBRE have competed successfully for independent NIH R01-type research support. The same is expected of the present junior faculty. Once the present junior faculty are funded externally, they will financially rotate off the grant to make room for addition of new junior faculty members. Another important feature of the Proposal is to maintain 4 research Cores to provide additional research support for the Center's faculty. These cores include an administrative Core as well as Cores in the areas of biospecimen, histopathology, analytical, and sequencing. In summary, the outstanding combination of scientific talent, existing research environment, and new core facilities ensure that this proposed Center will further foster the development of a thematic multidisciplinary research center, to enhance the ability of new investigators to compete independently for complementary NIH and other external peer-reviewed support, and to strengthen existing biomedical research infrastructure at KUMC.

Public Health Relevance

The liver has many functions in the body, such as elimination of drugs and other non-nutritious chemicals in our diet;interconverting fat, glucose, and amino acids;regulating the amount of cholesterol, sugar, and clotting agents;secreting bile acids for the absorption of lipids and lipid-soluble vitamins from our diets, etc. This interdisciplinary group of scientists are working together to understand how the liver performs these functions and how to repair the liver when it fails.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
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Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Zlotnik, Hinda
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University of Kansas
Schools of Medicine
Kansas City
United States
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Ni, Hong-Min; Williams, Jessica A; Ding, Wen-Xing (2015) Mitochondrial dynamics and mitochondrial quality control. Redox Biol 4:13-Jun
Stieger, Bruno; Hagenbuch, Bruno (2014) Organic anion-transporting polypeptides. Curr Top Membr 73:205-32
Xie, Yuchao; McGill, Mitchell R; Dorko, Kenneth et al. (2014) Mechanisms of acetaminophen-induced cell death in primary human hepatocytes. Toxicol Appl Pharmacol 279:266-74
Manley, Sharon; Ni, Hong-Min; Kong, Bo et al. (2014) Suppression of autophagic flux by bile acids in hepatocytes. Toxicol Sci 137:478-90
Ni, Hong-Min; Woolbright, Benjamin L; Williams, Jessica et al. (2014) Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy. J Hepatol 61:617-25
McGill, Mitchell R; Cao, Mengde; Svetlov, Archie et al. (2014) Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans. Biomarkers 19:222-30
Du, Kuo; Williams, C David; McGill, Mitchell R et al. (2014) Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase. Toxicol Appl Pharmacol 281:58-66
Steiner, Konstanze; Hagenbuch, Bruno; Dietrich, Daniel R (2014) Molecular cloning and functional characterization of a rainbow trout liver Oatp. Toxicol Appl Pharmacol 280:534-42
Li, Jibiao; Bi, Lipeng; Hulke, Michelle et al. (2014) Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice. J Biol Chem 289:22437-49
Kandel, Sylvie E; Lampe, Jed N (2014) Role of protein-protein interactions in cytochrome P450-mediated drug metabolism and toxicity. Chem Res Toxicol 27:1474-86

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