The Administrative and Scientific Development Core (Core A) will provide administrative, fiscal, and scientific support for the proposed Center for Microbial Pathogenesis and Host Inflammatory Responses by operating and maintaining a COBRE Center (Aim 1), fostering scientific growth through mentoring and faculty development (Aim 2), and fostering growth and expansion of the COBRE Center and its programs (Aim 3). The Center's goal is to address infectious disease in a therapeutically relevant fashion by understanding both the microbial virulence factors that contribute to the disease process and how these factors impact the host immunological and inflammatory response to determine the ultimate clinical outcome. The Administrative and Scientific Development Core will rely on Internal and External Advisory Committees, experienced mentors, and a seasoned administrative team operating under the leadership of the Center Director to guide four Project Leaders who focus on the Center's theme to independent external funding. The Core's leadership team will also develop a "pipeline" of potential Project Leaders?junior investigators and experienced scientists who are interested in becoming active in research regarding microbial pathogens and host response?and will continue to support Project Leaders who have "graduated" to external funding at the ROI level. This Core will also train new mentors, initiate a Distinguished Lecturer Series to attract new scientists to the field, provide pilot funding to encourage new research, and evaluate the Center and its projects. Successful operation of this Core will enable the Center to achieve the following milestones within 5 years of funding: 3 independently funded new PIs associated with the Center, 2-4 new mentors, 3-5 potential new Project Leaders, 8-15 publications in peer-reviewed journals, and 1 program project grant in the early stages of planning.

Public Health Relevance

of this Core relates to its role in supporting a Center that will address the persistent problem of infectious disease, specifically the role of pathogens and their impact on the body's immunological and inflammatory response. This Core will provide administrative, fiscal, and scientific support for scientists who will investigate complex interactions between microbial pathogens and their human hosts from the perspectives of both the pathogen itself and the host response. Their work has the potential to significantly enhance the ability to control the devastating consequences of many infectious diseases, including those caused by pathogens that are resistant to antibiotics.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103625-02
Application #
8523925
Study Section
Special Emphasis Panel (ZRR1-RI-B)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
2
Fiscal Year
2013
Total Cost
$679,256
Indirect Cost
$218,745
Name
University of Arkansas for Medical Sciences
Department
Type
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Kovak, Matthew R; Saraswati, Sarika; Schoen, David J et al. (2014) Investigation of galectin-3 function in the reproductive tract by identification of binding ligands in human seminal plasma. Am J Reprod Immunol 72:403-12
Pawar, Snehalata A; Shao, Lijian; Chang, Jianhui et al. (2014) C/EBP? deficiency sensitizes mice to ionizing radiation-induced hematopoietic and intestinal injury. PLoS One 9:e94967
Winchell, Caylin G; Graham, Joseph G; Kurten, Richard C et al. (2014) Coxiella burnetii type IV secretion-dependent recruitment of macrophage autophagosomes. Infect Immun 82:2229-38
Nakagawa, Mayumi; Coleman, Hannah N; Wang, Xuelian et al. (2014) IL-12 secretion by Langerhans cells stimulated with Candida skin test reagent is mediated by dectin-1 in some healthy individuals. Cytokine 65:202-9
Maddukuri, Leena; Ketkar, Amit; Eddy, Sarah et al. (2014) The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa. Nucleic Acids Res 42:12027-40
Kennedy, Joshua L; Schroeder, Nikhila; Palacios, Thamiris et al. (2014) Fifty-five-year-old man with chronic yeast infections. Allergy Asthma Proc 35:415-22
Fortune, Danielle E; Lin, Yi-Pin; Deka, Ranjit K et al. (2014) Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection. Infect Immun 82:3186-98
Coleman, Carrie B; McGraw, Jennifer E; Feldman, Emily R et al. (2014) A gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivo. PLoS Pathog 10:e1003916
Groshong, Ashley M; Fortune, Danielle E; Moore, Brendan P et al. (2014) BB0238, a presumed tetratricopeptide repeat-containing protein, is required during Borrelia burgdorferi mammalian infection. Infect Immun 82:4292-306
Beenken, Karen E; Mrak, Lara N; Zielinska, Agnieszka K et al. (2014) Impact of the functional status of saeRS on in vivo phenotypes of Staphylococcus aureus?sarA mutants. Mol Microbiol 92:1299-312

Showing the most recent 10 out of 16 publications