The Administrative Core will serve as the centralized coordinating resource for the Oklahoma Developmental Biology COBRE. The Core Director will facilitate communication among the Oklahoma Junior Investigator and Pilot Project developmental biologists and their Mentors, ensure compliance with all NIH policies, and provide a foundation for scientific growth in basic and translational Developmental Biology research. The Administrative Core Director will be the primary contact for the Network of COBREs and the NIH. To accomplish these goals, the Administrative Core will focus on the following Specific Aims:
Aim 1. To provide central management for the Oklahoma Developmental Biology COBRE components and activities.
Aim 2. To provide mentoring for the Junior Investigators and assist with their transition to fully independent status.
Aim 3. To administer the Pilot Project Program.
Aim 4. To promote multidisciplinary approaches to research and interactions among the COBRE investigators through a vigorous monthly seminar program.
Aim 5. To facilitate interactions of the Oklahoma Developmental Biology COBRE with other COBREs and with the national program.
Aim 6. To provide fiscal management of the COBRE and compliance with regulatory issues.
Aim 7. To promote data sharing strategies.
|Duan, Hongliang; Arora, Daleep; Li, Yu et al. (2016) Identification of 1,2,3-triazole derivatives that protect pancreatic Î² cells against endoplasmic reticulum stress-mediated dysfunction and death through the inhibition of C/EBP-homologous protein expression. Bioorg Med Chem 24:2621-30|
|Borgogno, MarÃa V; Monti, Mariela R; Zhao, Weixing et al. (2016) Tolerance of DNA Mismatches in Dmc1 Recombinase-mediated DNA Strand Exchange. J Biol Chem 291:4928-38|
|Tsou, Pei-Suen; Wren, Jonathan D; Amin, M Asif et al. (2016) Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors. Arthritis Rheumatol 68:2975-2985|
|Griffin, Timothy M; Humphries, Kenneth M; Kinter, Michael et al. (2016) Nutrient sensing and utilization: Getting to the heart of metabolic flexibility. Biochimie 124:74-83|
|Duan, Hongliang; Lee, Jae Wook; Moon, Sung Won et al. (2016) Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic Î²-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress. J Med Chem 59:7783-800|
|Siefert, Joseph C; Clowdus, Emily A; Sansam, Christopher L (2015) Cell cycle control in the early embryonic development of aquatic animal species. Comp Biochem Physiol C Toxicol Pharmacol 178:8-15|
|Larabee, Chelsea M; Georgescu, Constantin; Wren, Jonathan D et al. (2015) Expression profiling of the ubiquitin conjugating enzyme UbcM2 in murine brain reveals modest age-dependent decreases in specific neurons. BMC Neurosci 16:76|
|Dozmorov, Mikhail G; Adrianto, Indra; Giles, Cory B et al. (2015) Detrimental effects of duplicate reads and low complexity regions on RNA- and ChIP-seq data. BMC Bioinformatics 16 Suppl 13:S10|
|Pezza, Roberto J (2015) Mechanisms of chromosome segregation in meiosis--new views on the old problem of aneuploidy. FEBS J 282:2424-5|
|Lee, Chih-Ying; Horn, Henning F; Stewart, Colin L et al. (2015) Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes. Cell Rep 11:551-63|
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