The overall objectives of is to Improve the quality and quantity of cancer research at the University of Oklahoma Hearth Sciences Center (OUHSC), to increase NIH funding in Oklahoma through the mentoring of promising junior investigators (PJIs) and to develop support for the infrastructure for cancer research, this COBRE grant will greatly strengthen cancer research in Oklahoma and enhance the research base, infrastructure, and core capacities of the Cancer Center. The focused and structured mentoring experience that the COBRE grant supports will be a determinative influence helping PJIs achieve independent national funding. Finally, as has been seen on campus in the areas of Vision, Diabetes, Dental Sciences and Microbial Pathogenesis, the CoBRE grant will help accelerate the development of the Cancer Center as it progresses towards a submitting a competitive NCI Cancer Center Support Grant application.
The Specific Aims of this CBRE application are: 1. To mentor promising junior investigators (PJIs) In cancer research, enabling them to become independent NIH-funded investigators. Four PJIs have been selected. Each has been assigned a mentor and a co-mentor who are established cancer researchers in Oklahoma with expertise related to the PJI's project. The four PJIs have diverse but related projects that are integrated under the overall theme of "Tumor Biology: Resistance to Cancer Therapy and Mitigating Strategies." 2. To establish and develop research infrastructure to support cancer research, optimize the research environment for the PJIs, and form a core resource for the developing Stephenson Oklahoma Cancer Center. Four shared Cores will be established in this COBRE to assist the PJI projects and to serve the cancer research community in Oklahoma. 3. To foster and enhance collaborations between basic scientists and clinicians, and to facilitate translational research directed toward the development of new diagnostics and treatments for cancer.
Cancer represents a major health burden in the US. Ultimately, alleviating the burden of cancer will come from research: the generation of new ideas and, consequently, the development of novel agents. A COBRE grant will allow the Oklahoma Cancer Center to provide PJIs a focused mentoring experience to help them mature into independently-funded investigators contributing to the overall fight against cancer.
|Boswell-Casteel, Rebba C; Johnson, Jennifer M; Duggan, Kelli D et al. (2014) FUN26 (function unknown now 26) protein from saccharomyces cerevisiae is a broad selectivity, high affinity, nucleoside and nucleobase transporter. J Biol Chem 289:24440-51|
|Aravindan, Natarajan; Aravindan, Sheeja; Pandian, Vijayabaskar et al. (2014) Acquired tumor cell radiation resistance at the treatment site is mediated through radiation-orchestrated intercellular communication. Int J Radiat Oncol Biol Phys 88:677-85|
|Bio, Moses; Rajaputra, Pallavi; Nkepang, Gregory et al. (2014) Far-red light activatable, multifunctional prodrug for fluorescence optical imaging and combinational treatment. J Med Chem 57:3401-9|
|Janakiram, Naveena B; Mohammed, Altaf; Brewer, Misty et al. (2014) Raloxifene and antiestrogenic gonadorelin inhibits intestinal tumorigenesis by modulating immune cells and decreasing stem-like cells. Cancer Prev Res (Phila) 7:300-9|
|Babu, Anish; Wang, Qi; Muralidharan, Ranganayaki et al. (2014) Chitosan coated polylactic acid nanoparticle-mediated combinatorial delivery of cisplatin and siRNA/Plasmid DNA chemosensitizes cisplatin-resistant human ovarian cancer cells. Mol Pharm 11:2720-33|
|Xiong, Xunhao; Arvizo, Rochelle R; Saha, Sounik et al. (2014) Sensitization of ovarian cancer cells to cisplatin by gold nanoparticles. Oncotarget 5:6453-65|
|Aravindan, S; Natarajan, M; Ramraj, S K et al. (2014) Abscopal effect of low-LET ýý-radiation mediated through Rel protein signal transduction in a mouse model of nontargeted radiation response. Cancer Gene Ther 21:54-9|
|VandenHeuvel, Katherine A; Carpentieri, David F; Chen, Jie et al. (2014) Ectomesenchymoma with embryonal rhabdomyosarcoma and ganglioneuroma, arising in association with benign triton tumor of the tongue. Pediatr Dev Pathol 17:226-30|
|Aravindan, Sheeja; Natarajan, Mohan; Herman, Terence S et al. (2013) Radiation-induced TNF* cross signaling-dependent nuclear import of NF*B favors metastasis in neuroblastoma. Clin Exp Metastasis 30:807-17|
|Chang, Theodore S; Lin, Hsueh-Kung; Rogers, Kyle A et al. (2013) Expression of aldo-keto reductase family 1 member C3 (AKR1C3) in neuroendocrine tumors & adenocarcinomas of pancreas, gastrointestinal tract, and lung. Int J Clin Exp Pathol 6:2419-29|
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