The number of investigators who use rodents in their research has gone from two in 2001 to over 18 in 2011. Many of these faculty members have extramural funding and others have recently been hired with competitive start-up packages and the expectation of significant scholarship productivity. The proposed renovations to the current laboratory facilities, accomplished with the $500,000 one-time allocation for renovations, will result in significantly upgraded and expanded laboratory space dedicated to pain and neuropharmacology testing. This space will house a behavioral core facility and create additional renovated space for new faculty recruits. In the last three years, the university has designated the entire back portion of Stella Maris to research (~10,000 sf of labs and offices) and has completely renovated two of the four floors of the building. UNE has also installed a backup generator to cover critical power needs of the animal facility and key research equipment, and has made other investments in the heating and fire safety systems of the building. We propose further upgrades in portions of the building that still need full environmental control (central versus window air conditioners), additional electrical capacity to cover equipment and HVAC needs, and renovation of the 4""""""""^ floor labs to provide additional quality space for the behavioral core. These upgrades will provide modern office, laboratory and vivarium space that has been designed by the users, including the COBRE PI and core directors. Providing dedicated space for core equipment and services and high quality research labs for investigators is critical to this success of the Center.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
1P20GM103643-01A1
Application #
8466102
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
Project End
Budget Start
2012-08-15
Budget End
2013-05-31
Support Year
1
Fiscal Year
2012
Total Cost
$495,000
Indirect Cost
Name
University of New England
Department
Type
DUNS #
071735252
City
Biddeford
State
ME
Country
United States
Zip Code
04005
Govea, Rosann M; Barbe, Mary F; Bove, Geoffrey M (2017) Group IV nociceptors develop axonal chemical sensitivity during neuritis and following treatment of the sciatic nerve with vinblastine. J Neurophysiol 118:2103-2109
Lei, Wei; Mullen, Nathan; McCarthy, Sarah et al. (2017) Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain. J Biol Chem 292:10414-10428
Havelin, Joshua; Imbert, Ian; Sukhtankar, Devki et al. (2017) Mediation of Movement-Induced Breakthrough Cancer Pain by IB4-Binding Nociceptors in Rats. J Neurosci 37:5111-5122
Follansbee, Taylor L; Gjelsvik, Kayla J; Brann, Courtney L et al. (2017) Drosophila Nociceptive Sensitization Requires BMP Signaling via the Canonical SMAD Pathway. J Neurosci 37:8524-8533
Cormier, Jim; Cone, Katherine; Lanpher, Janell et al. (2017) Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis. Life Sci 180:51-59
Allen, Joshua; Imbert, Ian; Havelin, Joshua et al. (2017) Effects of Treadmill Exercise on Advanced Osteoarthritis Pain in Rats. Arthritis Rheumatol 69:1407-1417
McLane, Virginia D; Bergquist, Ivy; Cormier, James et al. (2017) Long-term morphine delivery via slow release morphine pellets or osmotic pumps: Plasma concentration, analgesia, and naloxone-precipitated withdrawal. Life Sci 185:1-7
Harasawa, Ichiro; Johansen, Joshua P; Fields, Howard L et al. (2016) Alterations in the rostral ventromedial medulla after the selective ablation of ?-opioid receptor expressing neurons. Pain 157:166-73
Havelin, Joshua; Imbert, Ian; Cormier, Jennifer et al. (2016) Central Sensitization and Neuropathic Features of Ongoing Pain in a Rat Model of Advanced Osteoarthritis. J Pain 17:374-82
Malon, Jennifer T; Cao, Ling (2016) Preparation of Primary Mixed Glial Cultures from Adult Mouse Spinal Cord Tissue. J Vis Exp :

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