Purposeful human behavior requires attention, decisions and action, all basic functions mediated by brain networks primarily located in the neocortex, but modulated and shaped by sub-cortical processing. Behavioral and brain mechanisms of attention, including vigilance, orienting and perceptual and action selection, are key gateways into high-level function. Thus, in a general and even specific sense, attention, decision making and the ensuing actions define human mental activities. Deficits in these functions are common in both neurological and psychiatric disorders and can result in a wide range of higher-order behavioral deficits. We propose to establish a COBRE Center for Central Nervous System Function at Brown University that will investigate the mechanisms of higher brain function, with a focus on attention, decision making and action and disorders that modify these key systems, using a combination of genetic, behavior, and systems neuroscience approaches. This COBRE consists of five research projects led by junior faculty. Morrow will investigate the neurobiology of children diagnosed with "difficult-to-treat autism," a group that often presents with obsessive compulsive behaviors. Amso will investigate the typical development of visual selective attention and the mechanisms of its disruption in autism spectrum disorder. Worden will examine selective attention mechanisms resulting from conflict. Asaad will investigate interactions between neocortex and basal ganglia during attention-based associative decision-making. Song will investigate how multiple neural systems become integrated to select actions, such as choosing to pick up a red instead of a blue pencil. A Design and Analysis Core will facilitate the research goals of these projects and benefit the broader Brown community by developing new tools and optimizing existing ones to image brain structure and function with MRI and EEG and neural recordings;and ensuring proper experimental design and analysis procedures across projects. Project leaders will benefit from senior faculty mentors who will provide support and guidance on research, publication, and grant preparation. An Administrative Core will oversee the operations of this COBRE (Center. The COBRE Center for Central Nervous System Function will fall under the auspices of the Brown Institute for Brain Science. The COBRE Center will leverage the administrative resources available through the Brown Institute for Brain Science to ensure efficient operation and coordinate with other brain science research activities at Brown.

Public Health Relevance

Deficits in attention, decision-making and action are common in both neurological and psychiatric disorders and can result in a wide range of higher-order behavioral deficits. The research under this COBRE Center for Central Nervous System Function is relevant to disorders such as Alzheimer's disease, autism, attention deficit disorder, brain injury, optic ataxia, and depression.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103645-02
Application #
8721442
Study Section
Special Emphasis Panel (ZGM1-TWD-B (CB))
Program Officer
Canto, Maria Teresa
Project Start
2013-08-15
Project End
2018-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
2
Fiscal Year
2014
Total Cost
$2,197,454
Indirect Cost
$780,441
Name
Brown University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Song, Joo-Hyun; B├ędard, Patrick (2015) Paradoxical benefits of dual-task contexts for visuomotor memory. Psychol Sci 26:148-58
Moher, Jeff; Sit, Jonathan; Song, Joo-Hyun (2015) Goal-directed action is automatically biased towards looming motion. Vision Res 113:188-97
Aguiar, Derek; Wong, Wendy S W; Istrail, Sorin (2014) Tumor haplotype assembly algorithms for cancer genomics. Pac Symp Biocomput :3-14
Amso, Dima; Haas, Sara; Markant, Julie (2014) An eye tracking investigation of developmental change in bottom-up attention orienting to faces in cluttered natural scenes. PLoS One 9:e85701
Pescosolido, Matthew F; Stein, David M; Schmidt, Michael et al. (2014) Genetic and phenotypic diversity of NHE6 mutations in Christianson syndrome. Ann Neurol 76:581-93
Schlesinger, Matthew; Johnson, Scott P; Amso, Dima (2014) Prediction-learning in infants as a mechanism for gaze control during object exploration. Front Psychol 5:441
Moher, Jeff; Song, Joo-Hyun (2014) Perceptual decision processes flexibly adapt to avoid change-of-mind motor costs. J Vis 14:1
Amso, Dima; Haas, Sara; Tenenbaum, Elena et al. (2014) Bottom-up attention orienting in young children with autism. J Autism Dev Disord 44:664-73
Corbett, Jennifer E; Song, Joo-Hyun (2014) Statistical extraction affects visually guided action. Vis cogn 22:881-895
McLean, Rebecca L; Johnson Harrison, Ashley; Zimak, Eric et al. (2014) Executive function in probands with autism with average IQ and their unaffected first-degree relatives. J Am Acad Child Adolesc Psychiatry 53:1001-9

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