This proposal is to create a Center of Biomedical Research Excellence (COBRE) in Integrative Neuroscience at the University of Nevada, Reno (UNR). Research in the neurosciences is proceeding on many fronts and addressing fundamental questions in both basic and clinical science.
The aim of this COBRE is to establish a research center that can promote interdisciplinary interactions and investigations of neural function, impairments, and repair, by bridging and cross-fertilizing several research units at UNR that have already developed teams of focused expertise in neuroscience, from molecular to behavioral and from understanding normal structure and function to neurological deficits and their treatment. The center will span 3 different colleges and the Medical School, and will support projects led by 5 highly accomplished junior faculty drawn from the departments of Psychology, Biology, Biomedical Engineering, and Physiology and Cell Biology. The research and professional development of these faculty will be mentored by a strong team of successful researchers who will also bring perspectives and expertise drawn from many disciplines. The center will also provide the infrastructure to support the projects as well as new research opportunities throughout the institution by establishing two new core facilities. One core will support training, use, and analysis of structural and functional magnetic resonance imaging (MRl). This core will provide - for the first time - access at UNR to the now standard research tools provided by MRl. The second core will support investigations directed at different patient populations by developing a database that will allow researchers to identify and recruit participants with well defined neurological lesions. Both the center and new core facilities will expand research strengths and translational neuroscience at UNR in entirely new directions, while providing infrastructure that has broad applications in both basic and clinical research and can thus support use and research synergisms across many disciplines and programs on campus and in the state.

Public Health Relevance

Neurological impairments and disease are a major focus of healthcare, and understanding and treating these impairments is central to the mission of many institutes at NIH. The COBRE will support research that will help to characterize both the healthy brain and neural disorders, and will advance knowledge ranging from the neural basis of behavior to neural damage and repair.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Program Officer
Gorospe, Rafael
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Nevada Reno
Schools of Arts and Sciences
United States
Zip Code
Skiba, Rafal M; Snow, Jacqueline C (2016) Attentional capture for tool images is driven by the head end of the tool, not the handle. Atten Percept Psychophys 78:2500-2514
Erlikhman, Gennady; Caplovitz, Gideon P (2016) Decoding information about dynamically occluded objects in visual cortex. Neuroimage :
Moreno-Bravo, Juan A; Martinez-Lopez, Jesus E; Madrigal, M Pilar et al. (2016) Developmental guidance of the retroflex tract at its bending point involves Robo1-Slit2-mediated floor plate repulsion. Brain Struct Funct 221:665-78
Gruner, Hannah; Cortés-López, Mariela; Cooper, Daphne A et al. (2016) CircRNA accumulation in the aging mouse brain. Sci Rep 6:38907
Stephens, Jaclyn A; Berryhill, Marian E (2016) Older Adults Improve on Everyday Tasks after Working Memory Training and Neurostimulation. Brain Stimul 9:553-9
Zhang, Yong; Lamba, Pallavi; Guo, Peiyi et al. (2016) miR-124 Regulates the Phase of Drosophila Circadian Locomotor Behavior. J Neurosci 36:2007-13
Erlikhman, Gennady; Gurariy, Gennadiy; Mruczek, Ryan E B et al. (2016) The neural representation of objects formed through the spatiotemporal integration of visual transients. Neuroimage 142:67-78
Downing, Laura E; Ferguson, Bradley S; Rodriguez, Kelvin et al. (2016) A grape seed procyanidin extract inhibits HDAC activity leading to increased Pparα phosphorylation and target-gene expression. Mol Nutr Food Res :
Kim, Kyung-Tai; Kim, Namhee; Kim, Hwan-Ki et al. (2016) ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons. Sci Rep 6:36491
Bjorke, Brielle; Shoja-Taheri, Farnaz; Kim, Minkyung et al. (2016) Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling. Neural Dev 11:18

Showing the most recent 10 out of 62 publications