The overall purpose of the Administrative Core of the Cardiopulmonary Vascular Biology COBRE is to facilitate the research activities and career development of junior investigators who will go on to successfully apply for independent research support and become independent investigators. These objectives will be met by a comprehensive program of mentored individual research projects plus a career development curriculum. The objectives of the Administrative Core are: 1. The Administrative Core will provide junior investigators with structures for mentoring, career development training, and administrative support. 2. The Administrative Core will identify pilot investigators and will arrange for mentoring and career development support as they begin to develop research programs in the cardiopulmonary field. 3. The Administrative Core will identify and add new junior investigators, as junior investigators become independent researchers. 4. The Administrative Core will organize meetings of Mentoring, Executive,"""""""" Internal Advisory, and External Advisory Committees, weekly COBRE meetings, and the annual COBRE research symposium. 5. The Administrative Core will manage consortium agreements with collaborating institutions. 6. The Administrative Core will collect data for formative and summative evaluations of junior and pilot investigator progress. The overall objective of the Cardiopulmonary Vascular Biology COBRE will be attained by a program of mentored research with talented junior investigators teamed with expert faculty mentors with extensive mentoring experience and productive and well-equipped laboratories. Progress toward independence of junior investigators will be monitored, using well-defined benchmarks of progress. The Administrative Core is critical to organization, scheduling, and facilitation and documentation of progress toward research independence described below.
Cardiovascular and lung vascular diseases are important causes of morbidity and mortality in the US. A multidisciplinary group of MD, PhD, and MD/PhD investigators will develop a research center focusing on understanding the biology of vascular injury. Administrative Core will be critical to accomplishment of the goals of the COBRE.
|Baird, Grayson L; Archer-Chicko, Christine; Barr, R Graham et al. (2018) Lower DHEA-S levels predict disease and worse outcomes in post-menopausal women with idiopathic, connective tissue disease- and congenital heart disease-associated pulmonary arterial hypertension. Eur Respir J 51:|
|Shah, Nishant R; Blankstein, Ron; Villines, Todd et al. (2018) Coronary CTA for Surveillance of Cardiac Allograft Vasculopathy. Curr Cardiovasc Imaging Rep 11:26|
|Monaghan, Sean F; Banerjee, Debasree; Chung, Chun-Shiang et al. (2018) Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness. Mol Med 24:32|
|Potz, Brittany A; Scrimgeour, Laura A; Pavlov, Vasile I et al. (2018) Extracellular Vesicle Injection Improves Myocardial Function and Increases Angiogenesis in a Swine Model of Chronic Ischemia. J Am Heart Assoc 7:|
|Zhou, Yang; He, Chuan Hua; Yang, Daniel S et al. (2018) Galectin-3 Interacts with the CHI3L1 Axis and Contributes to Hermansky-Pudlak Syndrome Lung Disease. J Immunol 200:2140-2153|
|Zhao, Haifeng; Dennery, Phyllis A; Yao, Hongwei (2018) Metabolic reprogramming in the pathogenesis of chronic lung diseases, including BPD, COPD, and pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 314:L544-L554|
|Chambers, Eboni; Rounds, Sharon; Lu, Qing (2018) Pulmonary Endothelial Cell Apoptosis in Emphysema and Acute Lung Injury. Adv Anat Embryol Cell Biol 228:63-86|
|Sellke, Nicholas; Kuczmarski, Alex; Lawandy, Isabella et al. (2018) Enhanced coronary arteriolar contraction to vasopressin in patients with diabetes after cardiac surgery. J Thorac Cardiovasc Surg 156:2098-2107|
|Fallon, Eleanor A; Biron-Girard, Bethany M; Chung, Chun-Shiang et al. (2018) A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis. J Leukoc Biol :|
|Aldosari, Sarah; Awad, Maan; Harrington, Elizabeth O et al. (2018) Subcellular Reactive Oxygen Species (ROS) in Cardiovascular Pathophysiology. Antioxidants (Basel) 7:|
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