The substantia nigra, pars compacta (SNc) is a structure that modulates voluntary motor control, and the death of the dopaminergic neurons in the SNc leads to many of the classic motor deficits associated with the Parkinson's disease (PD). Most conventional treatments alleviate symptoms but do not prevent the eventual death of neurons in the SNc. While fetal tissue transplant and stem cell therapy serve to replace lost cells, incomplete knowledge on dopamine neuron development within the SNc has limited the effectiveness of these treatments as most cells in the transplant fail to survive. Elucidating the factors that modulate dopamine neural development could lead to novel treatment approaches or increase the effectiveness of these replacement therapies in PD. In the rat brain, progesterone receptors (PRs) are expressed transiently in the perinatal SNc, suggesting a role for this hormone in the development of this region. Dr. Mennella proposes to characterize the temporal expression pattern of progesterone receptors in the mouse substantia nigra and determine their roles in the morphological and phenotypic development of that region. She also proposes to use PR knock-out (PRKO) mice to determine if absence of PRs during development leads to greater dopaminergic cell loss in the adult SNc, and more immature projections into the straitum, the primary recipient of SNc dopamine projections and greater motor deficits in adulthood.
Parkinson's disease (PD) is a devastating age-related movement disorder caused by the progressive death of brain cells. Identifying factors that contribute to the disease could aid in prevention and cessation ofthe disease. Developmental abnormalities in the brain may confer susceptibility to PD. Exposure to the hormone progesterone during development could protect the brain against the onset of PD.
|Urban, Kimberly R; Layfield, Dylan M; Griffin, Amy L (2014) Transient inactivation of the medial prefrontal cortex impairs performance on a working memory-dependent conditional discrimination task. Behav Neurosci 128:639-43|
|Ouyang, Liangqi; Shaw, Crystal L; Kuo, Chin-Chen et al. (2014) In vivo polymerization of poly(3,4-ethylenedioxythiophene) in the living rat hippocampus does not cause a significant loss of performance in a delayed alternation task. J Neural Eng 11:026005|
|Boschen, Karen E; Hamilton, Gillian F; Delorme, James E et al. (2014) Activity and social behavior in a complex environment in rats neonatally exposed to alcohol. Alcohol 48:533-41|
|Patel, Kinjal; Shaheen, Nagma; Witherspoon, Jessica et al. (2014) Mucus trail tracking in a predatory snail: olfactory processing retooled to serve a novel sensory modality. Brain Behav 4:83-94|
|Asok, Arun; Bernard, Kristin; Rosen, Jeffrey B et al. (2014) Infant-caregiver experiences alter telomere length in the brain. PLoS One 9:e101437|
|Hill, Kathryn T; Warren, Megan; Roth, Tania L (2014) The influence of infant-caregiver experiences on amygdala Bdnf, OXTr, and NPY expression in developing and adult male and female rats. Behav Brain Res 272:175-80|
|Grygoruk, Anna; Chen, Audrey; Martin, Ciara A et al. (2014) The redistribution of Drosophila vesicular monoamine transporter mutants from synaptic vesicles to large dense-core vesicles impairs amine-dependent behaviors. J Neurosci 34:6924-37|
|Roth, Tania L; Matt, Stephanie; Chen, Kenneth et al. (2014) Bdnf DNA methylation modifications in the hippocampus and amygdala of male and female rats exposed to different caregiving environments outside the homecage. Dev Psychobiol 56:1755-63|
|Mersha, Mahlet; Formisano, Rosaria; McDonald, Rochelle et al. (2013) GPA-14, a G?(i) subunit mediates dopaminergic behavioral plasticity in C. elegans. Behav Brain Funct 9:16|
|Hallock, Henry L; Arreola, Adrian C; Shaw, Crystal L et al. (2013) Dissociable roles of the dorsal striatum and dorsal hippocampus in conditional discrimination and spatial alternation T-maze tasks. Neurobiol Learn Mem 100:108-16|
Showing the most recent 10 out of 13 publications