The genetic basis of human disease has been an underlying focus the biomedical sciences for almost a century, and was a major motivating factor behind the human genome project. With the explosion of genomic data that has brought on the age of personalized medicine, the role of computational analyses has become critical for all forms of inquiry. Increasingly, clinicians and basic scientists are confronted with massive genomic data sets that contain important answers to medical problems, but discovery is hindered by limited computational expertise. The COBRE Center for Computational Biology of Human Disease is intended to embrace this age of genomic medicine from an explicitly computational angle. Five Junior Investigators will lead research projects on that focus on different diseases such as cancer, respiratory and age- related diseases and preeclampsia, but are united by common computational and bioinformatic challenges of large genomic data sets. By building a collaborative Center of empirical and computational scientists, we will be able to advance new discoveries, algorithms and genetic and genomic screening approaches with direct relevance to several human diseases. The associated Administrative Core of this Center will provide a strong supportive context for these specific research projects, while also providing a broad base of support for the growth of collaborative research efforts on human disease at Brown University and its Affiliated Hospitals.

Public Health Relevance

The explosion of genomic data that underlies personalized medicine has been enabled by computational analyses across many lines of biomedical science inquiry. The COBRE Center for Computational Biology of Human Disease is intended to embrace this age of genomic medicine by building a collaborative Center of basic biologists, clinicians and computational scientists to uncover new approaches to the study of human diseases. This Center is consistent with NIH's commitment to Computational Biology and Bioinformatics.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM109035-03
Application #
9433663
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2018-03-01
Budget End
2019-02-28
Support Year
3
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Brown University
Department
Type
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
Grizotte-Lake, Mayara; Vaishnava, Shipra (2018) Autophagy: Suicide Prevention Hotline for the Gut Epithelium. Cell Host Microbe 23:147-148
Atkinson, Elizabeth Grace; Audesse, Amanda Jane; Palacios, Julia Adela et al. (2018) No Evidence for Recent Selection at FOXP2 among Diverse Human Populations. Cell 174:1424-1435.e15
Zabat, Michelle A; Sano, William H; Wurster, Jenna I et al. (2018) Microbial Community Analysis of Sauerkraut Fermentation Reveals a Stable and Rapidly Established Community. Foods 7:
Lee, Kayla M; Morris-Love, Jenna; Cabral, Damien J et al. (2018) Coinfection With Influenza A Virus and Klebsiella oxytoca: An Underrecognized Impact on Host Resistance and Tolerance to Pulmonary Infections. Front Immunol 9:2377
Crane, Meredith J; Lee, Kayla M; FitzGerald, Ethan S et al. (2018) Surviving Deadly Lung Infections: Innate Host Tolerance Mechanisms in the Pulmonary System. Front Immunol 9:1421
Crane, Meredith J; Xu, Yun; Henry Jr, William L et al. (2018) Pulmonary influenza A virus infection leads to suppression of the innate immune response to dermal injury. PLoS Pathog 14:e1007212
Zabat, Michelle A; Sano, William H; Cabral, Damien J et al. (2018) The impact of vegan production on the kimchi microbiome. Food Microbiol 74:171-178
Cabral, Damien J; Wurster, Jenna I; Belenky, Peter (2018) Antibiotic Persistence as a Metabolic Adaptation: Stress, Metabolism, the Host, and New Directions. Pharmaceuticals (Basel) 11:
Sugden, Lauren Alpert; Atkinson, Elizabeth G; Fischer, Annie P et al. (2018) Localization of adaptive variants in human genomes using averaged one-dependence estimation. Nat Commun 9:703
Cabral, Damien J; Penumutchu, Swathi; Norris, Colby et al. (2018) Microbial competition between Escherichia coli and Candida albicans reveals a soluble fungicidal factor. Microb Cell 5:249-255

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