Boise State University has an emerging record of excellence in matrix biology research and application to many of the most challenging health concerns facing our nation. To date, we have been limited by a centralized mechanism to leverage new collaborations efficiently into new research discoveries. To capitalize on the broad, diverse research base that exists at Boise State, we propose to create the Center of Biomedical Research Excellence (COBRE) in Matrix Biology. The primary goals ofthe COBRE in Matrix Biology are 1) to support junior investigators, 2) to enhance the productivity of established scientists, 3) to facilitate collaboration between both junior and established researchers with those bringing non-traditional strategies to the table, and 4) to build biomedical research infrastructure at Boise State University. Major programmatic emphases of the COBRE in Matrix Biology will be to support the analysis of animal models of relevance to cell-extracellular matrix interactions in disease progression and tissue repair/regeneration and to provide access to research instrumentation and technical support. Through the Administrative Core, the COBRE in Matrix Biology will sponsor career development of junior investigators, establishment of new collaborations behween established investigators, activities that will promote the exchange of information, ideas and reagents between COBRE members, and to engage non-members who are doing meritorious research within the thematic focus ofthe COBRE in Matrix Biology. The Administrative Core will implement a Pilot Project grant program to provide funding to young investigators and to established investigators who propose to apply their expertise to matrix biology.
Health disorders involving the extracellular matrix of tissues and organs are a main cause of pain and suffering leading to diminished quality of life. The successful completion of the proposed aims will improve research infrastructure and career development of junior investigators, to address the mission of 17 Institutes at NIH that prioritize cell-extracellular matrix interactions.
|MourÃ£o, AndrÃ©; Bonnal, Sophie; Soni, Komal et al. (2016) Structural basis for the recognition of spliceosomal SmN/B/B' proteins by the RBM5 OCRE domain in splicing regulation. Elife 5:|
|Turner, Matthew W; Cruz, Roberto; Mattos, Jared et al. (2016) Cyclopamine bioactivity by extraction method from Veratrum californicum. Bioorg Med Chem 24:3752-7|
|Morrison, Brad E (2016) Discovery of nigral dopaminergic neurogenesis in adult mice. Neural Regen Res 11:878-81|
|Krueger, Eric; Shim, Jiwook; Fathizadeh, Arman et al. (2016) Modeling and Analysis of Intercalant Effects on Circular DNA Conformation. ACS Nano 10:8910-7|
|Bryant, Sheenah; Shrestha, Nisha; Carnig, Paul et al. (2016) Purinergic control of lysenin's transport and voltage-gating properties. Purinergic Signal 12:549-59|
|Krueger, Eric; Bryant, Sheenah; Shrestha, Nisha et al. (2016) Intramembrane congestion effects on lysenin channel voltage-induced gating. Eur Biophys J 45:187-94|
|Porter, Stephen M; Dailey, Hannah L; Hollar, Katherine A et al. (2016) Automated measurement of fracture callus in radiographs using portable software. J Orthop Res 34:1224-33|
|Albright, Joshua E; Stojkovska, Iva; Rahman, Abir A et al. (2016) Nestin-positive/SOX2-negative cells mediate adult neurogenesis of nigral dopaminergic neurons in mice. Neurosci Lett 615:50-4|
|Harvey, Wendy A; Jurgensen, Kimberly; Pu, Xinzhu et al. (2016) Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases human hepatic stellate cell activation. Toxicology 344-346:26-33|
|Elkins, Jacob; Marsh, J Lawrence; Lujan, Trevor et al. (2016) Motion Predicts Clinical Callus Formation: Construct-Specific Finite Element Analysis of Supracondylar Femoral Fractures. J Bone Joint Surg Am 98:276-84|
Showing the most recent 10 out of 27 publications