The overarching goal of the Biomolecular Research Core is to provide critical components of the research infrastructure needed for the success of our biomedical research programs. Access to instrumentation is essential in enabling Boise State University to build a research capability that will support researchers in their endeavor to carry out multidisciplinary research. The Biomolecular Research Core will support junior investigators within the COBRE in Matrix Biology as well as more established biomedical researchers. The Core facility will be equipped for histology, microscopy, and mass spectrometry for proteomics and metabolomics analysis. In partnership with the University of Idaho and Idaho State University, junior investigators will have access to next generation sequencing instrumentation and technical staff, which will allow them to combine transcriptomics with proteomics. The recent campus-wide effort to increase cyberinfrastructure will support both junior and established investigators in data analysis, modeling, simulation and visualization. The Core will enhance current and future NIH-supported research. Establishing and operating the Core will be integral to Center of Biomedical Research Excellence in Matrix Biology and will enable sustainable biomedical research growth at Boise State. This facility will be sustained through a business plan based on a fee-for-service model.
Successful completion of these aims will enhance the environment and the capabilities of researchers in the Boise State COBRE in Matrix Biology, leading to new approaches to address disorders of the extracellular matrix and new collaborations between COBRE faculty who may have not previously included proteomics genomics, imaging, or microscopy.
|MourÃ£o, AndrÃ©; Bonnal, Sophie; Soni, Komal et al. (2016) Structural basis for the recognition of spliceosomal SmN/B/B' proteins by the RBM5 OCRE domain in splicing regulation. Elife 5:|
|Turner, Matthew W; Cruz, Roberto; Mattos, Jared et al. (2016) Cyclopamine bioactivity by extraction method from Veratrum californicum. Bioorg Med Chem 24:3752-7|
|Morrison, Brad E (2016) Discovery of nigral dopaminergic neurogenesis in adult mice. Neural Regen Res 11:878-81|
|Krueger, Eric; Shim, Jiwook; Fathizadeh, Arman et al. (2016) Modeling and Analysis of Intercalant Effects on Circular DNA Conformation. ACS Nano 10:8910-7|
|Bryant, Sheenah; Shrestha, Nisha; Carnig, Paul et al. (2016) Purinergic control of lysenin's transport and voltage-gating properties. Purinergic Signal 12:549-59|
|Krueger, Eric; Bryant, Sheenah; Shrestha, Nisha et al. (2016) Intramembrane congestion effects on lysenin channel voltage-induced gating. Eur Biophys J 45:187-94|
|Porter, Stephen M; Dailey, Hannah L; Hollar, Katherine A et al. (2016) Automated measurement of fracture callus in radiographs using portable software. J Orthop Res 34:1224-33|
|Albright, Joshua E; Stojkovska, Iva; Rahman, Abir A et al. (2016) Nestin-positive/SOX2-negative cells mediate adult neurogenesis of nigral dopaminergic neurons in mice. Neurosci Lett 615:50-4|
|Harvey, Wendy A; Jurgensen, Kimberly; Pu, Xinzhu et al. (2016) Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases human hepatic stellate cell activation. Toxicology 344-346:26-33|
|Elkins, Jacob; Marsh, J Lawrence; Lujan, Trevor et al. (2016) Motion Predicts Clinical Callus Formation: Construct-Specific Finite Element Analysis of Supracondylar Femoral Fractures. J Bone Joint Surg Am 98:276-84|
Showing the most recent 10 out of 27 publications