Proposed is the West Virginia Stroke CoBRE (here after called the Stroke CoBRE) with a focus area of stroke. The Stroke CoBRE was initiated as an essential part of the Center for Basic and Translational Stroke Research (CBTSR), a newly formed Center that is focused on enhancing basic and translational stroke research on the West Virginia University (WVU) campus to reduce the burden of stroke. Our approach is to address the mechanisms by which risk factors, particularly prevalent in our Appalachian population, affect stroke and thereby to decipher mechanisms of these risk factors and potential treatments that target these mechanisms. We envision that the CBTSR will become a national center of excellence in basic and translational stroke research that addresses bench to bed-side to community Issues in stroke. This will be accomplished through the development of junior Investigators to research Independence, and the development of core resources that support the WVU stroke research community, thereby enhancing resources and personnel devoted to stroke research at the WVU to achieve programmatic research activities. Three cores and five research projects are proposed. The Administrative Core will manage the various aspects of the Stroke CoBRE, including an intense junior faculty mentoring program, advisory committees and program evaluation. The Experimental Stroke Core will provide resources, expertise and experimental stroke procedures to junior Investigators as well as to the WVU neuroscience and cardiovascular research community. The Biostatistics Core will provide critical biostatistical support during the design and conduct of the junior Investigator-Initiated projects. The research projects proposed eminate from 5 junior Investigators who are committed to developing independent research programs through the CoBRE mechanism. Collectively, their research projects address the linked areas of stroke prediction, causes, prevention, acute treatment and rehabilitation. The program-as-a-whole has a well-developed and Intensive mentoring program and a rigorous summative and formative evaluation program. Institutional support is also proposed, in the form of faculty hires, facilities construction and monitary contributions.

Public Health Relevance

A national center for excellence in stroke research will serve to reduce the burden of stroke In West Virginia and the nation through cutting-edge research into the causes, prevention, acute treatment and rehabilitation of stroke. We will use bench to bed-side to community approaches and In the process enhance the number and quality of stroke reseachers at the West Virginia University and enable us to fund unique programs of research.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C1))
Program Officer
Canto, Maria Teresa
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
West Virginia University
Schools of Medicine
United States
Zip Code
Peterson-Burch, Frances; Reuter-Rice, Karin; Barr, Taura L (2017) Rethinking Recovery: Incorporating Holistic Nursing Perspectives in Poststroke Care. Holist Nurs Pract 31:3-6
Branyan, Kayla W; DeVallance, Evan R; Lemaster, Kent A et al. (2017) Role of Chronic Stress and Exercise on Microvascular Function in Metabolic Syndrome. Med Sci Sports Exerc :
Palle, Pushpalatha; Monaghan, Kelly L; Milne, Sarah M et al. (2017) Cytokine Signaling in Multiple Sclerosis and Its Therapeutic Applications. Med Sci (Basel) 5:
O'Connell, Grant C; Tennant, Connie S; Lucke-Wold, Noelle et al. (2017) Monocyte-lymphocyte cross-communication via soluble CD163 directly links innate immune system activation and adaptive immune system suppression following ischemic stroke. Sci Rep 7:12940
Sprenkle, Neil T; Sims, Savannah G; Sánchez, Cristina L et al. (2017) Endoplasmic reticulum stress and inflammation in the central nervous system. Mol Neurodegener 12:42
Asano, Shinichi; O'Connell, Grant C; Lemaster, Kent C et al. (2017) Circulating leucocytes perpetuate stroke-induced aortic dysfunction. Exp Physiol 102:1321-1331
O'Connell, Grant C; Treadway, Madison B; Petrone, Ashley B et al. (2017) Peripheral blood AKAP7 expression as an early marker for lymphocyte-mediated post-stroke blood brain barrier disruption. Sci Rep 7:1172
Chantler, Paul D (2017) Arterial Ventricular Uncoupling With Age and Disease and Recoupling With Exercise. Exerc Sport Sci Rev 45:70-79
Olesh, Erienne V; Pollard, Bradley S; Gritsenko, Valeriya (2017) Gravitational and Dynamic Components of Muscle Torque Underlie Tonic and Phasic Muscle Activity during Goal-Directed Reaching. Front Hum Neurosci 11:474
Sarkar, S; Jun, S; Rellick, S et al. (2016) Expression of microRNA-34a in Alzheimer's disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity. Brain Res 1646:139-151

Showing the most recent 10 out of 42 publications