The overall goal of the Administrative Core of the West Virginia Stroke CoBRE (hereafter called the Stroke CoBRE) is to manage the development of a center of excellence in basic and translational stroke research at the West Virginia University. To achieve this goal, the follow specific aims will be achieved:
Specific Aim 1 : To create a vision for the Stroke CoBRE and implement goals, strategies and tactics to realize this vision. Speciflc Aim 2: To develop and implement fiscal, administrative and scientific policies and processes for the Stroke CoBRE.
Specific Aim 3 : To develop high quality research, research training and career development in the Stroke CoBRE. All five research projects emanate from the research activifies of bright assistant professors in a tenure track in their respective departments. The themafic focus area is stroke and the projects assess linked areas ofthe predicfion, causes, prevention, acute treatment and rehabilitafion of stroke. Speciflc Aim 4: To foster an environment for the intellectual interacfions of program investigators and between program invesfigators and the WVUHSC community. Numerous mechanisms are in place or under development to foster the intellectual curiosity of faculty, fellows and students at the West Virginia University.
Specific Aim 5 : To develop and implement a mentoring program for junior faculty that addresses the transifion to and attainment of independent research funding. The process involves a contract between mentor and mentee;frequent interaction, not just behween mentor and mentee, but also among the laboratory staffs;an identificafion of career goals;iterative composifion and internal reviews of both manuscripts and grant applicafions;high standards for research accomplishment, both in terms of number and quality of the research product;sensitivity to the need to balance professional and personal lives for a sustainable career in research;and professionalizafion of the junior faculty, including their participation in the most relevant nafional and international scientific meeting, participation in journal and grant review activities, and involvement in the scientific societies that represent our discipline.
Specific Aim 6 : To development and implement a formafive and summative evaluation strategy with specific milestones.

Public Health Relevance

Regorous management of the West Virginia Stroke CoBRE is essesnfial to successfully developing a natioal center fro research excellence in stroke reseach. A centerpiece of our management program is intense mentoring of junior faculty to research independence and research program development.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
West Virginia University
United States
Zip Code
Sun, Jiahong; Ren, Xuefang; Qi, Wen et al. (2016) Geissoschizine methyl ether protects oxidative stress-mediated cytotoxicity in neurons through the 'Neuronal Warburg Effect'. J Ethnopharmacol 187:249-58
Engler-Chiurazzi, E B; Singh, M; Simpkins, J W (2016) From the 90's to now: A brief historical perspective on more than two decades of estrogen neuroprotection. Brain Res 1633:96-100
Engler-Chiurazzi, E B; Brown, C M; Povroznik, J M et al. (2016) Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury. Prog Neurobiol :
Engler-Chiurazzi, Elizabeth B; Covey, Douglas F; Simpkins, James W (2016) A novel mechanism of non-feminizing estrogens in neuroprotection. Exp Gerontol :
Petrone, Ashley B; O'Connell, Grant C; Regier, Michael D et al. (2016) The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity. Transl Stroke Res 7:103-10
Sarkar, S; Jun, S; Rellick, S et al. (2016) Expression of microRNA-34a in Alzheimer's disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity. Brain Res 1646:139-51
Hu, Heng; Doll, Danielle N; Sun, Jiahong et al. (2016) Mitochondrial Impairment in Cerebrovascular Endothelial Cells is Involved in the Correlation between Body Temperature and Stroke Severity. Aging Dis 7:14-27
Engler-Chiurazzi, Elizabeth B; Stapleton, Phoebe A; Stalnaker, Jessica J et al. (2016) Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior and cognition. J Toxicol Environ Health A 79:447-52
Sun, Jiahong; Hu, Heng; Ren, Xuefang et al. (2016) Tert-butylhydroquinone compromises survival in murine experimental stroke. Neurotoxicol Teratol 54:15-21
DeVallance, E; Fournier, S; Lemaster, K et al. (2016) The effects of resistance exercise training on arterial stiffness in metabolic syndrome. Eur J Appl Physiol 116:899-910

Showing the most recent 10 out of 31 publications