The overall goal of the Administrative Core of the West Virginia Stroke CoBRE (hereafter called the Stroke CoBRE) is to manage the development of a center of excellence in basic and translational stroke research at the West Virginia University. To achieve this goal, the follow specific aims will be achieved:
Specific Aim 1 : To create a vision for the Stroke CoBRE and implement goals, strategies and tactics to realize this vision. Speciflc Aim 2: To develop and implement fiscal, administrative and scientific policies and processes for the Stroke CoBRE.
Specific Aim 3 : To develop high quality research, research training and career development in the Stroke CoBRE. All five research projects emanate from the research activifies of bright assistant professors in a tenure track in their respective departments. The themafic focus area is stroke and the projects assess linked areas ofthe predicfion, causes, prevention, acute treatment and rehabilitafion of stroke. Speciflc Aim 4: To foster an environment for the intellectual interacfions of program investigators and between program invesfigators and the WVUHSC community. Numerous mechanisms are in place or under development to foster the intellectual curiosity of faculty, fellows and students at the West Virginia University.
Specific Aim 5 : To develop and implement a mentoring program for junior faculty that addresses the transifion to and attainment of independent research funding. The process involves a contract between mentor and mentee;frequent interaction, not just behween mentor and mentee, but also among the laboratory staffs;an identificafion of career goals;iterative composifion and internal reviews of both manuscripts and grant applicafions;high standards for research accomplishment, both in terms of number and quality of the research product;sensitivity to the need to balance professional and personal lives for a sustainable career in research;and professionalizafion of the junior faculty, including their participation in the most relevant nafional and international scientific meeting, participation in journal and grant review activities, and involvement in the scientific societies that represent our discipline.
Specific Aim 6 : To development and implement a formafive and summative evaluation strategy with specific milestones.

Public Health Relevance

Regorous management of the West Virginia Stroke CoBRE is essesnfial to successfully developing a natioal center fro research excellence in stroke reseach. A centerpiece of our management program is intense mentoring of junior faculty to research independence and research program development.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
West Virginia University
United States
Zip Code
Peterson-Burch, Frances; Reuter-Rice, Karin; Barr, Taura L (2017) Rethinking Recovery: Incorporating Holistic Nursing Perspectives in Poststroke Care. Holist Nurs Pract 31:3-6
Branyan, Kayla W; DeVallance, Evan R; Lemaster, Kent A et al. (2017) Role of Chronic Stress and Exercise on Microvascular Function in Metabolic Syndrome. Med Sci Sports Exerc :
Palle, Pushpalatha; Monaghan, Kelly L; Milne, Sarah M et al. (2017) Cytokine Signaling in Multiple Sclerosis and Its Therapeutic Applications. Med Sci (Basel) 5:
O'Connell, Grant C; Tennant, Connie S; Lucke-Wold, Noelle et al. (2017) Monocyte-lymphocyte cross-communication via soluble CD163 directly links innate immune system activation and adaptive immune system suppression following ischemic stroke. Sci Rep 7:12940
Sprenkle, Neil T; Sims, Savannah G; Sánchez, Cristina L et al. (2017) Endoplasmic reticulum stress and inflammation in the central nervous system. Mol Neurodegener 12:42
Asano, Shinichi; O'Connell, Grant C; Lemaster, Kent C et al. (2017) Circulating leucocytes perpetuate stroke-induced aortic dysfunction. Exp Physiol 102:1321-1331
O'Connell, Grant C; Treadway, Madison B; Petrone, Ashley B et al. (2017) Peripheral blood AKAP7 expression as an early marker for lymphocyte-mediated post-stroke blood brain barrier disruption. Sci Rep 7:1172
Chantler, Paul D (2017) Arterial Ventricular Uncoupling With Age and Disease and Recoupling With Exercise. Exerc Sport Sci Rev 45:70-79
Olesh, Erienne V; Pollard, Bradley S; Gritsenko, Valeriya (2017) Gravitational and Dynamic Components of Muscle Torque Underlie Tonic and Phasic Muscle Activity during Goal-Directed Reaching. Front Hum Neurosci 11:474
Sarkar, S; Jun, S; Rellick, S et al. (2016) Expression of microRNA-34a in Alzheimer's disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity. Brain Res 1646:139-151

Showing the most recent 10 out of 42 publications