Cardiovascular diseases (CVD) such as heart disease, heart failure, and stroke affect Delawareans at a rate significantly above the national average. In this application, we seek to establish a Center of Biomedical Research Excellence in Cardiovascular Health that can interface with the larger regional clinical and research mission and positively impact the cardiovascular health of our regional populations. This center will catalyze cardiovascular health research by fostering the independent research careers of a team of subproject new investigators, strengthen the research infrastructure and capacity to perform cardiovascular health research by establishing core facilities that will enhance the research capability of the five subproject principal investigators and other members of the Center, and develop a sustainable research center in cardiovascular health. The overall goal of the COBRE administrative core is to maximize the productivity and impact of each of the subprojects, core, and the center as a whole through effective management, mentoring and career development, evaluation, and expansion of the center. This will be accomplished by: 1) establishing effective management of administrative, fiscal, and scientific aspects of the proposed COBRE; 2) establishing an effective mentoring and career development plan to foster the independent research careers subproject new investigators; 3) monitoring the progress of the proposed COBRE toward milestones through the implementation of summative and formative evaluations; and 4) expanding the center through pilot grants to new investigators and targeted recruitment of research faculty with expertise in cardiovascular health. The administrative core outlines a leadership plan that includes the PI, an Internal Advisory Committee, an evaluator, and a to-be-formed External Advisory Committee. A mentoring program that complements the ongoing mentoring that occurs at the University of Delaware is described. Plans for graduating and replacing subproject investigators are also outlined.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
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Special Emphasis Panel (ZGM1)
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University of Delaware
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Patterson, Freda; Grandner, Michael A; Malone, Susan K et al. (2017) Sleep as a Target for Optimized Response to Smoking Cessation Treatment. Nicotine Tob Res :
Tremblay, Mark S; Aubert, Salomé; Barnes, Joel D et al. (2017) Sedentary Behavior Research Network (SBRN) - Terminology Consensus Project process and outcome. Int J Behav Nutr Phys Act 14:75
Patterson, Freda; Zaslav, David S; Kolman-Taddeo, Diana et al. (2017) Smoking Cessation in Pulmonary Care Subjects: A Mixed Methods Analysis of Treatment-Seeking Participation and Preferences. Respir Care 62:179-192
Nair, Uma S; Patterson, Freda; Rodriguez, Daniel et al. (2017) A telephone-based intervention to promote physical activity during smoking cessation: a randomized controlled proof-of-concept study. Transl Behav Med 7:138-147
Wenner, Megan M; Sebzda, Kelly N; Kuczmarski, Andrew V et al. (2017) ETB receptor contribution to vascular dysfunction in postmenopausal women. Am J Physiol Regul Integr Comp Physiol 313:R51-R57
Lenhart, Clare M; Wiemken, Andrew; Hanlon, Alexandra et al. (2017) Perceived neighborhood safety related to physical activity but not recreational screen-based sedentary behavior in adolescents. BMC Public Health 17:722
Casola, Allison R; Nelson, Deborah B; Patterson, Freda (2017) Sex Differences in Contraception Non-Use Among Urban Adolescents: Risk Factors for Unintended Pregnancy. J Sch Health 87:641-649
Wright, Regina S; Gerassimakis, Constance; Bygrave, Desirée et al. (2017) Dietary Factors and Cognitive Function in Poor Urban Settings. Curr Nutr Rep 6:32-40
Robson, Shannon M; Lozano, Alicia J; Papas, Mia et al. (2017) Food Insecurity and Cardiometabolic Risk Factors in Adolescents. Prev Chronic Dis 14:E110
Perkett, Mackenzie; Robson, Shannon M; Kripalu, Varsha et al. (2017) Characterizing Cardiovascular Health and Evaluating a Low-Intensity Intervention to Promote Smoking Cessation in a Food-Assistance Population. J Community Health 42:605-611

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