Cardiovascular diseases (CVD) such as heart disease, heart failure, and stroke affect Delawareans at a rate significantly above the national average. In this application, we seek to establish a Center of Biomedical Research Excellence in Cardiovascular Health that can interface with the larger regional clinical and research mission and positively impact the cardiovascular health of our regional populations. This center will catalyze cardiovascular health research by fostering the independent research careers of a team of subproject new investigators, strengthen the research infrastructure and capacity to perform cardiovascular health research by establishing core facilities that will enhance the research capability of the five subproject principal investigators and other members of the Center, and develop a sustainable research center in cardiovascular health. The overall goal of the COBRE administrative core is to maximize the productivity and impact of each of the subprojects, core, and the center as a whole through effective management, mentoring and career development, evaluation, and expansion of the center. This will be accomplished by: 1) establishing effective management of administrative, fiscal, and scientific aspects of the proposed COBRE; 2) establishing an effective mentoring and career development plan to foster the independent research careers subproject new investigators; 3) monitoring the progress of the proposed COBRE toward milestones through the implementation of summative and formative evaluations; and 4) expanding the center through pilot grants to new investigators and targeted recruitment of research faculty with expertise in cardiovascular health. The administrative core outlines a leadership plan that includes the PI, an Internal Advisory Committee, an evaluator, and a to-be-formed External Advisory Committee. A mentoring program that complements the ongoing mentoring that occurs at the University of Delaware is described. Plans for graduating and replacing subproject investigators are also outlined.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM113125-03
Application #
9432529
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2018-03-01
Budget End
2019-02-28
Support Year
3
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Delaware
Department
Type
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716
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Wenner, Megan M; Sebzda, Kelly N; Kuczmarski, Andrew V et al. (2017) ETB receptor contribution to vascular dysfunction in postmenopausal women. Am J Physiol Regul Integr Comp Physiol 313:R51-R57
Nair, Uma S; Patterson, Freda; Rodriguez, Daniel et al. (2017) A telephone-based intervention to promote physical activity during smoking cessation: a randomized controlled proof-of-concept study. Transl Behav Med 7:138-147
Wright, Regina S; Gerassimakis, Constance; Bygrave, Desirée et al. (2017) Dietary Factors and Cognitive Function in Poor Urban Settings. Curr Nutr Rep 6:32-40

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