TheproposedUniversityofKentuckyCenterforCancerandMetabolism(CCM)isdesignedtoaddressa significantgapincancerresearchbyprovidingthemultidisciplinaryinfrastructuretosupportcareer developmentintheareaofmetabolicreprogrammingofthetumormicroenvironment.Routineandhigh-end imagingconstituteacriticalcomponentofthiseffort,astheabilitytovisualizeandquantifytargetmolecules andtheireffectsoncellularstructureandfunctionareheavilydependentontheavailabilityandqualityofthe imagingsystems.TheImagingCoreinthisapplicationwillprovidetechnicalservicesandsupportforCCM projectresearchlaboratoriesandpilotprojectrecipientsandiswellpositionedtoadvancetheCCMmissionin cancerandmetabolismthroughdeliveryofanexpandedrangeofimagingservicestoCOBREinvestigators andothers.ThiswillbeaccomplishedbytheachievementofthreeSpecificAims:
SpecificAim1. Toprovide project-specifictrainingandconsultationforCOBREinvestigators.
SpecificAim2. Todevelopand/oradapt state-of-theartimagingtechniquestoenhancetheresearchofearly-stageandpilotprojectCOBRE investigators.
SpecificAim3. Todevelopandimplementnewmethods,suchasproject-specificsample preparation,toenhanceCCMimagingservicesandmakesuchservicesavailabletoCOBREandnon-COBRE users.ImagingCoreuserswillhaveaccesstothisno-costfacilitywhereinvestigatorscanevaluatetheirtissue orcellularsamplesusingvarioustypesofinstruments.Thecorewillalsosupportroutineanalysisaswellas introduceinvestigatorstohigh-endimagingoptionsandcapabilitiesrelevanttotheirstudies,therebyfacilitating theresearchsuccessesoftheseusers.Dr.JianhangJia,theDirectoroftheImagingCore,isahighly productiveinvestigatorwhohassuccessfullyobtainedsubstantialextramuralresearchsupportthatrelies extensivelyonsophisticatedimagingcapabilities.Hehas,thus,investedextensiveeffortinthedevelopment andimprovementofinstrumentationwithintheMarkeyCancerCenter.HewillconsultwithCCMinvestigators onthedesignofexperimentsusingimagingmodalities,arolethatheassumedinguidingthedevelopmentof thefourCCMresearchprojectsinthisapplication.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM121327-02
Application #
9441817
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40526
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