This application is for a NIMHD Exploratory Center of Excellence (P20) grant for a 5 year competitive renewal of the National Institute of Minority Health and Health Disparities'Center of Excellence (COE) at North Carolina Central University (NCCU). Renamed as the NCCU Center for Translational Health Equality Research, this Center will integrate and centralize ongoing minority health and health disparities research into a single interdisciplinary and trans-disciplinary enterprise and establish novel effective partnerships with organizations and communities for conducting basic and translational research that ultimately results in positive transformations in minority health and elimination of health disparities. The Center will be committed to focus on minority health and specifically on the higher prevalence of cardiometabolic risk in minorities that result in morbidity and mortality rates in excess of the general U.S. population. The Center will be operated via four cores: 1) Administrative;2) Research;3) Research Training and Education;and 4) Community Engagement and Outreach. The Research Core will oversee 2 full projects as described in the grant application, while fostering novel transdisciplinary partnerships with investigators from Nursing, Public Health, Computer Science, Education and community organizations serving the medical needs of minority populations. Finally, the Community Engagement and Outreach Core will conduct studies on a rural medically underserved minority population in North Caroling to explore the role of factors, such as community health-promoting infrastructure and interpersonal relationships, in positively and continuously affecting trajectories of type 2 diabetes progression in this community. These pioneering community engagement projects will be pivotal in assessing optimal strategies for disease management and participation among minority communities to improve cardiometabolic health and eliminate health disparities. Overall, the NCCU Center for Translational Health Equality Research will exemplify a center of research excellence through the assimilation of innovative multidisciplinary basic and translational research that promotes minority health and reduces health disparities, exemplary research training and education that increases the number of meritorious researchers from minority and medically underserved populations, and pioneering Outreach studies that actively engages a rural minority community in effective and sustainable activities for improve community health and better disease management.

Public Health Relevance

Obesity, hypertension, and diabetes disproportionately affect African Americans. Sustainable changes in diet and behavior can help to reduce these diseases. This application aims to find ways to promote long-term diet quality and glucose control.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
5P20MD000175-12
Application #
8488471
Study Section
Special Emphasis Panel (ZMD1-RN (01))
Program Officer
Tabor, Derrick C
Project Start
2002-09-30
Project End
2017-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
12
Fiscal Year
2013
Total Cost
$1,140,168
Indirect Cost
$308,380
Name
North Carolina Central University
Department
Type
Organized Research Units
DUNS #
783691801
City
Durham
State
NC
Country
United States
Zip Code
27707
Eldeeb, Khalil; Leone-Kabler, Sandra; Howlett, Allyn C (2016) CB1 cannabinoid receptor-mediated increases in cyclic AMP accumulation are correlated with reduced Gi/o function. J Basic Clin Physiol Pharmacol 27:311-22
Pointer, Mildred A; Hicks, Kianda; Williams-Devane, ClarLynda et al. (2015) Gender differences in preclinical markers of kidney injury in a rural north Carolina african-american cohort. Front Public Health 3:7
Beauchamp, B; Ghosh, S; Dysart, M W et al. (2015) Low birth weight is associated with adiposity, impaired skeletal muscle energetics and weight loss resistance in mice. Int J Obes (Lond) 39:702-11
Sesay, John S; Gyapong, Reginald N K; Najafi, Leila T et al. (2015) Gαi/o-dependent Ca(2+) mobilization and Gαq-dependent PKCα regulation of Ca(2+)-sensing receptor-mediated responses in N18TG2 neuroblastoma cells. Neurochem Int 90:142-51
Ghosh, Sujoy; Vivar, Juan; Nelson, Christopher P et al. (2015) Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease. Arterioscler Thromb Vasc Biol 35:1712-22
Chatterjee, Pradeep K (2015) Directing enhancer-traps and iTol2 end-sequences to deleted BAC ends with loxP- and lox511-Tn10 transposons. Methods Mol Biol 1227:99-122
Pointer, Mildred A; Eley, Shaleka; Anderson, Lauren et al. (2015) Differential Effect of Renal Cortical and Medullary Interstitial Fluid Calcium on Blood Pressure Regulation in Salt-Sensitive Hypertension. Am J Hypertens 28:1049-55
Spruiell, Krisstonia; Gyamfi, Afua A; Yeyeodu, Susan T et al. (2015) Pregnane X Receptor-Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity. J Pharmacol Exp Ther 354:459-70
Rankinen, Tuomo; Sarzynski, Mark A; Ghosh, Sujoy et al. (2015) Are there genetic paths common to obesity, cardiovascular disease outcomes, and cardiovascular risk factors? Circ Res 116:909-22
Singh, Vandana; Raghuwanshi, Sandeep K; Smith, Nikia et al. (2014) G Protein-coupled receptor kinase-6 interacts with activator of G protein signaling-3 to regulate CXCR2-mediated cellular functions. J Immunol 192:2186-94

Showing the most recent 10 out of 58 publications