Clark Atlanta University (CAU) is a premier minority serving educational institution that imparts both undergraduate and graduate programs in various disciplines including biology. Graduates from CAU are predominantly of African-American descent, therefore we firmly believe that they are in a better position to address social, educational and health disparities In the United States. African Americans are also significantly under-represented in biological research. This is partly due to lack of institutional commitment, educational facilities, early intervention programs at the undergraduate level and lack of strong graduate programs In predominantly minority regions. This proposal Is a continuation of our previous program that was largely successful and is a step forward in preparing deserving our students for a strong and committed career In prostate cancer research. We will continue to offer a disease specific program designed specifically for a minority population that is more susceptible to prostate cancer. We successfully recruited and trained more than 20 undergraduate students in prostate cancer research through the summer internship program who presented quality research at many national and international meetings. Our first group of graduate students will begin graduating this year and most have published their research in peer reviewed journals. Due to our success, we propose to continue with the same overall hypothesis and specific aims from the original application. These are: 1) Structured undergraduate cancer research training through summer internship program;2) Development of focused prostate cancer research programs to foster collaboration and maximize program outcomes;3) Development of activities that will allow students to gain competitive advantage in cancer research;4) Train graduate students for a career in prostate cancer research;and 5) Effective recruitment and retention strategy at the graduate level. Our primary objective Is therefore

Public Health Relevance

Exposing undergraduate students to a structured cancer research program will provide learning experiences that will establish a foundation for more targeted cancer research at the graduate level. The proposal provides financial support to recruit and retain graduate students, support scientific interactions, develop collaborative projects, expose students to contemporary research and foster long-term collaborations.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Exploratory Grants (P20)
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Special Emphasis Panel (ZMD1-RN)
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Clark Atlanta University
United States
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Muniyan, Sakthivel; Chou, Yu-Wei; Tsai, Te-Jung et al. (2015) p66Shc longevity protein regulates the proliferation of human ovarian cancer cells. Mol Carcinog 54:618-31
Brown, Shanora G; Knowell, Ashley E; Hunt, Aisha et al. (2015) Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis. Prostate 75:266-79
Smith, Basil; Randle, Diandra; Mezencev, Roman et al. (2014) Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin D. Molecules 19:3988-4005
Burton, Liza J; Barnett, Petrina; Smith, Basil et al. (2014) Muscadine grape skin extract reverts snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells. BMC Complement Altern Med 14:97
Mandal, S; Abebe, F; Chaudhary, J (2014) -174G/C polymorphism in the interleukin-6 promoter is differently associated with prostate cancer incidence depending on race. Genet Mol Res 13:139-51
Smith, Bethany N; Burton, Liza J; Henderson, Veronica et al. (2014) Snail promotes epithelial mesenchymal transition in breast cancer cells in part via activation of nuclear ERK2. PLoS One 9:e104987
Gryder, Berkley E; Akbashev, Michelle J; Rood, Michael K et al. (2013) Selectively targeting prostate cancer with antiandrogen equipped histone deacetylase inhibitors. ACS Chem Biol 8:2550-60
Chetram, Mahandranauth A; Hinton, Cimona V (2013) ROS-mediated regulation of CXCR4 in cancer. Front Biol (Beijing) 8:
Strong, Nicole; Millena, Ana C; Walker, Lindsey et al. (2013) Inhibitor of differentiation 1 (Id1) and Id3 proteins play different roles in TGFýý effects on cell proliferation and migration in prostate cancer cells. Prostate 73:624-33
Chetram, Mahandranauth A; Bethea, Danaya A; Odero-Marah, Valerie A et al. (2013) ROS-mediated activation of AKT induces apoptosis via pVHL in prostate cancer cells. Mol Cell Biochem 376:63-71

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