Obesity-related health disparities represent one of the most significant public health challenges facing our society. In particular, obese Latino adolescents are disproportionately impacted by insulin resistance, psychosocial consequences, and type 2 diabetes but few prevention interventions have been conducted in this vulnerable and underserved group. Therefore, we propose a randomized-controlled trial to test the efficacy of a culturally-grounded, community-based diabetes prevention program to increase insulin sensitivity and weight-specific quality of life in 160 obese Latino adolescents. We will also explore potential mediators and moderators of the intervention's effects and estimate the initial incremental cost-effectiveness of the intervention for increasing insulin sensitivity. The intervention is guided by Social Cognitive Theory and framed within a multilevel ecodevelopmental model to address surrounding contextual factors that are thought to influence health behaviors and health outcomes in obese Latino youth during a critical life period. The project builds upon extant collaborations of a transdisciplinary team of investigators with the community to address critical gaps in how prevention interventions for obese Latino youth are developed, implemented and evaluated. This innovative approach is an essential step in the development of cost-effective, solution oriented programs to improve the health of Latino youth.

Public Health Relevance

Obesity and type 2 diabetes are critical public health issues affecting Latino youth. This study will test the effects and incremental cost-effectiveness of a culturally-grounded community-based lifestyle intervention on obesity-related health outcomes among obese Latino adolescents.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZMD1-RN)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Arizona State University-Tempe Campus
United States
Zip Code
Kulis, Stephen S; Ayers, Stephanie L; Harthun, Mary L (2017) Substance Use Prevention for Urban American Indian Youth: A Efficacy Trial of the Culturally Adapted Living in 2 Worlds Program. J Prim Prev 38:137-158
Williams, Allison N; Konopken, Yolanda P; Keller, Colleen S et al. (2017) Culturally-grounded diabetes prevention program for obese Latino youth: Rationale, design, and methods. Contemp Clin Trials 54:68-76
Petrov, Megan E; Vander Wyst, Kiley B; Whisner, Corrie M et al. (2017) Relationship of Sleep Duration and Regularity with Dietary Intake Among Preschool-Aged Children with Obesity from Low-Income Families. J Dev Behav Pediatr 38:120-128
Sangalang, Cindy C; Tran, Alisia G T T; Ayers, Stephanie L et al. (2016) Bullying among Urban Mexican-heritage Youth: Exploring Risk for Substance Use by Status as a Bully, Victim, and Bully-Victim. Child Youth Serv Rev 61:216-221
Muñoz-Ruiz, Miguel; Ribot, Julie C; Grosso, Ana R et al. (2016) TCR signal strength controls thymic differentiation of discrete proinflammatory ?? T cell subsets. Nat Immunol 17:721-727
Kulis, Stephen S; Robbins, Danielle E; Baker, Tahnee M et al. (2016) A latent class analysis of urban American Indian youth identities. Cultur Divers Ethnic Minor Psychol 22:215-28
Kulis, Stephen S; Jager, Justin; Ayers, Stephanie L et al. (2016) Substance Use Profiles of Urban American Indian Adolescents: A Latent Class Analysis. Subst Use Misuse 51:1159-73
Ayón, Cecilia; Baldwin, Adrienne; Umaña-Taylor, Adriana J et al. (2016) Agarra el momento/seize the moment: Developing communication activities for a drug prevention intervention with and for Latino families in the US Southwest. Qual Soc Work 15:281-299
Lopez, Vera; Dustman, Patricia; Williams, Tiffany (2016) Drug-involved Mexican-origin girls' HIV prevention needs: A pilot study. Women Health 56:326-44
Yoo, Hyung Chol; Jackson, Kelly F; Guevarra, Rudy P et al. (2016) Construction and initial validation of the Multiracial Experiences Measure (MEM). J Couns Psychol 63:198-209

Showing the most recent 10 out of 109 publications