Abstract

The purpose of this Research Core is to provide oversight for the three research projects included in the proposal and to ensure communication between the investigators involved. The Pi/Director of the Research Core, Dr. Dorothy Tuan, in addition to leading one of the research projects will be responsible for providing oversight for the overall conduct of the projects. The Pis and co-investigators of the three research projects (Drs. Tuan, Kutlar, Ikuta, and Meiler) participate in regular monthly SCD research meetings and discussions where they exchange ideas. They have a track record of collaboration on SCD related research projects. As the PI of the Research Core, Dr. Tuan will be responsible to conduct regular monthly meetings to ensure progress of individual research projects, to discuss and resolve problems and pitfalls, and to communicate findings and results. Dr. Tuan will also ensure that the projects adequately utilize existing resources on the MCG campus. She will work closely with individual project leaders (Drs. Kutlar and Ikuta) to make sure that the projects are conducted in a responsible manner and that adequate measures for the protection of human research subjects and animals are observed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
5P20MD003383-04
Application #
8572437
Study Section
Special Emphasis Panel (ZRG1-EMNR-L (52))
Project Start
2009-05-28
Project End
2013-12-31
Budget Start
2012-01-05
Budget End
2012-12-31
Support Year
4
Fiscal Year
2012
Total Cost
$195,914
Indirect Cost
$68,077

  Institution

Name
Georgia Regents University
Department
Type
DUNS #
966668691
City
Augusta
State
GA
Country
United States
Zip Code
30912

  Publications

Zhu, Xingguo; Hu, Tianxiang; Ho, Meng Hsuan et al. (2017) Hydroxyurea differentially modulates activator and repressors of ?-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with Index of Hydroxyurea Responsiveness. Haematologica 102:1995-2004
Piel, Frédéric B; Adamkiewicz, Thomas V; Amendah, Djesika et al. (2016) Observed and expected frequencies of structural hemoglobin variants in newborn screening surveys in Africa and the Middle East: deviations from Hardy-Weinberg equilibrium. Genet Med 18:265-74
Anea, Ciprian B; Lyon, Matthew; Lee, Itia A et al. (2016) Pulmonary platelet thrombi and vascular pathology in acute chest syndrome in patients with sickle cell disease. Am J Hematol 91:173-8
Ikuta, Tohru; Sellak, Hassan; Odo, Nadine et al. (2016) Nitric Oxide-cGMP Signaling Stimulates Erythropoiesis through Multiple Lineage-Specific Transcription Factors: Clinical Implications and a Novel Target for Erythropoiesis. PLoS One 11:e0144561
Baker, Charlotte; Grant, Althea M; George, Mary G et al. (2015) Contribution of Sickle Cell Disease to the Pediatric Stroke Burden Among Hospital Discharges of African-Americans-United States, 1997-2012. Pediatr Blood Cancer 62:2076-81
Jaja, Cheedy; Bowman, Latanya; Wells, Leigh et al. (2015) Preemptive Genotyping of CYP2C8 and CYP2C9 Allelic Variants Involved in NSAIDs Metabolism for Sickle Cell Disease Pain Management. Clin Transl Sci 8:272-80
Jaja, Cheedy; Patel, Niren; Scott, Stuart A et al. (2014) CYP2C9 allelic variants and frequencies in a pediatric sickle cell disease cohort: implications for NSAIDs pharmacotherapy. Clin Transl Sci 7:396-401
Gutsaeva, Diana R; Montero-Huerta, Pedro; Parkerson, James B et al. (2014) Molecular mechanisms underlying synergistic adhesion of sickle red blood cells by hypoxia and low nitric oxide bioavailability. Blood 123:1917-26
Ghoshal, Pushpankur; Rajendran, Mythilypriya; Odo, Nadine et al. (2014) Glycosylation inhibitors efficiently inhibit P-selectin-mediated cell adhesion to endothelial cells. PLoS One 9:e99363
Ikuta, Tohru; Kuroyanagi, Yuichi; Odo, Nadine et al. (2013) A common signaling pathway is activated in erythroid cells expressing high levels of fetal hemoglobin: a potential role for cAMP-elevating agents in ?-globin disorders. J Blood Med 4:149-59

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