This core contains four projects, each of which involves outreach and interaction with the Sickle Cell community. The projects described in this core involve the SC community in both the development and evaluation of effective treatments/interventions that reduce health disparities in the treatment of SCD. The interaction with the SC community is integral to the success of each of these projects. The projects are:1) The provision of adequate treatment for pain crisis in the ER, 2) Health care transition preparation for young people with SCD moving from pediatric to adult oriented care, 3) The establishment and evaluation of an Advance Medical Home for patients with SCD and 4) A science camp/university experience for high school age young people with SCD to learn about the science and scientists developing treatments for SCD.
|Gutsaeva, Diana R; Montero-Huerta, Pedro; Parkerson, James B et al. (2014) Molecular mechanisms underlying synergistic adhesion of sickle red blood cells by hypoxia and low nitric oxide bioavailability. Blood 123:1917-26|
|Ikuta, Tohru; Thatte, Hemant S; Tang, Jay X et al. (2011) Nitric oxide reduces sickle hemoglobin polymerization: potential role of nitric oxide-induced charge alteration in depolymerization. Arch Biochem Biophys 510:53-61|
|Gutsaeva, Diana R; Parkerson, James B; Yerigenahally, Shobha D et al. (2011) Inhibition of cell adhesion by anti-P-selectin aptamer: a new potential therapeutic agent for sickle cell disease. Blood 117:727-35|
|Ikuta, Tohru; Adekile, Adekunle D; Gutsaeva, Diana R et al. (2011) The proinflammatory cytokine GM-CSF downregulates fetal hemoglobin expression by attenuating the cAMP-dependent pathway in sickle cell disease. Blood Cells Mol Dis 47:235-42|