The overall goal of this initiative is to strengthen the research infrastructure for cancer research at Florida A&M University through research collaboration in a focused and coordinated effort. Despite significant discovery of chemotherapeutic agents and their mechanisms of action, the need for new chemical entities having new mechanisms of action for the treatment of breast and lung cancer remains high. Therefore, an aggressive exploitation of new anticancer agents/combination and their molecular mechanisms involved in tumor regression are planned through research collaboration. Breast and lung cancer are the most common cancer affecting minority populations and these two cancers hence been chosen to be pursued at FAMU. Furthermore, FAMU has researchers who are performing cutting edge research in these areas and hence can contribute in building a strong infrastructure for other researchers. Another impetus for this activity is to take a step towards remedy for the persistent disparity in the number of minority investigators involved in targeted cancer therapy research. The difficulty in implementing innovative approaches in cancer research at historically black colleges and universities is due to the lack of adequate resources, trained investigators and research infrastructure for breast and lung cancer therapy.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
5P20MD006738-03
Application #
8611739
Study Section
Special Emphasis Panel (ZMD1-RN)
Project Start
Project End
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
3
Fiscal Year
2014
Total Cost
$145,022
Indirect Cost
$38,280
Name
Florida Agricultural and Mechanical University
Department
Type
DUNS #
623751831
City
Tallahassee
State
FL
Country
United States
Zip Code
32307
Godugu, Chandraiah; Doddapaneni, Ravi; Singh, Mandip (2017) Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC). Colloids Surf B Biointerfaces 153:208-219
Mack, Nzinga; Mazzio, Elizabeth A; Bauer, David et al. (2017) Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival. Anticancer Res 37:1205-1212
Doddapaneni, Ravi; Patel, Ketan; Chowdhury, Nusrat et al. (2017) Reversal of drug-resistance by noscapine chemo-sensitization in docetaxel resistant triple negative breast cancer. Sci Rep 7:15824
Messeha, Samia S; Zarmouh, Najla O; Mendonca, Patricia et al. (2017) The attenuating effects of plumbagin on pro-inflammatory cytokine expression in LPS-activated BV-2 microglial cells. J Neuroimmunol 313:129-137
Mazzio, Elizabeth A; Bauer, David; Mendonca, Patricia et al. (2017) Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2- in LPS/IFN? activated glioma cells. J Neuroimmunol 302:10-19
Kutlehria, Shallu; Behl, Gautam; Patel, Ketan et al. (2017) Cholecalciferol-PEG Conjugate Based Nanomicelles of Doxorubicin for Treatment of Triple-Negative Breast Cancer. AAPS PharmSciTech :
Mazzio, Elizabeth A; Soliman, Karam F A (2017) HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. Cancer Genomics Proteomics 14:17-33
Mendonca, Patricia; Taka, Equar; Bauer, David et al. (2017) The attenuating effects of 1,2,3,4,6 penta-O-galloyl-?-d-glucose on inflammatory cytokines release from activated BV-2 microglial cells. J Neuroimmunol 305:9-15
Ali, Askal Ayalew; Xiao, Hong; Tawk, Rima et al. (2017) Comparison of health utility weights among elderly patients receiving breast-conserving surgery plus hormonal therapy with or without radiotherapy. Curr Med Res Opin 33:391-400
Mathis, Arlesia L; Rooks, Ronica N; Tawk, Rima H et al. (2017) Neighborhood Influences and BMI in Urban Older Adults. J Appl Gerontol 36:692-708

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